期刊
JOURNAL OF CLINICAL LABORATORY ANALYSIS
卷 32, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/jcla.22205
关键词
coronary artery disease; exercise stress test; neutrophil count; neutrophil to lymphocyte ratio
ObjectiveTreadmill exercise stress testing for identifying patients with a higher likelihood of coronary artery disease (CAD) before elective coronary angiography is recommended in the current guidelines. In this study, we aimed to evaluate the changes in the hematological parameters before and after exercise stress test in relation with the presence of CAD. MethodsA total of 113 patients with chest pain who underwent treadmill exercise testing and coronary angiography were included in this study. ResultsNeutrophil count (4.380.99 vs 5.19 +/- 0.93, P<.001), and neutrophil to lymphocyte ratio (NLR) (2.04 +/- 0.63 vs 2.41 +/- 0.78, P<.001) were significantly elevated after treadmill exercise test in all the patients. Increase in the NLR after exercise test was significantly higher in patients with positive exercise test (n=68) than negative exercise test (n=45) (0.49 +/- 0.58 vs 0.19 +/- 0.44, P=.016). The sensitivity and specificity of treadmill exercise testing according to coronary angiography was 79% and 64%, respectively. A cut-off point of 0.2 for the change in the NLR in addition to positive treadmill exercise testing had 91% sensitivity and 92% specificity in predicting significant coronary artery stenosis (AUC:0.913, 95% CI: 0.805-1.000, P<.001). ConclusionsNeutrophil to lymphocyte ratio is an important inflammatory marker that can contribute to treadmill ECG testing in predicting CAD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据