Article
Endocrinology & Metabolism
Zhigang Shi, Alyssa C. Bonillas, Jennifer Wong, Stephanie L. Padilla, Virginia L. Brooks
Summary: The study reveals that NPY in the hypothalamus suppresses sympathetic nerve activity in brown adipose tissue and influences heart rate and blood pressure via Y1R. Downstream pathways for BAT SNA may involve direct projections to the RPa and PVN.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Yermek Rakhat, Kentaro Kaneko, Lei Wang, Wanxin Han, Yutaka Seino, Daisuke Yabe, Toshihiko Yada
Summary: d-allulose can suppress hunger-associated feeding and inhibit hunger-promoting neurons in the hypothalamic arcuate nucleus.
Review
Cell Biology
Yinqiong Huang, Xiahong Lin, Shu Lin
Summary: This research over the past decade has suggested that the pathogenic mechanisms of metabolic syndrome involve both peripheral tissues and central metabolic regulation imbalances. The hypothalamus, particularly the arcuate nucleus, is highlighted as the control center for metabolic homeostasis and energy balance, with Neuropeptide Y neurons playing a crucial role in integrating peripheral metabolic signals with the brain center. The manuscript aims to provide an overview of Neuropeptide Y's regulatory effects on metabolic syndrome and discuss clinical intervention strategies for neurometabolic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Juan Carlos Martinez-Camarillo, Christine K. Spee, Gloria Paulina Trujillo-Sanchez, Anthony Rodriguez, David R. Hinton, Alessandra Giarola, Victor Pikov, Arun Sridhar, Mark S. Humayun, Andrew C. Weitz
Summary: Modulating ocular sympathetic activity can affect the progression of age-related macular degeneration. Surgical and pharmacological inhibition of ocular sympathetic activity can inhibit the development of CNV.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Physiology
Kenju Miki, Shizuka Ikegame, Misa Yoshimoto
Summary: This review discusses how multiple baroreflex loops modulate sympathetic nerve activity in a region-specific and coordinated manner throughout the body, through evaluating the responses during freezing, REM sleep, and treadmill exercise.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Zhigang Shi, Daniel S. Stornetta, Ruth L. Stornetta, Virginia L. Brooks
Summary: The study revealed that AngII acting through AT1aR in ArcN region triggers different sympathetic nerve activation responses in female and male rats, playing a crucial role in regulating arterial pressure and heart rate, with variations existing in different physiological states. The expression of AT1aR may indirectly mediate the regulatory effects of AngII on AP and SNA through local endogenous interneurons.
Article
Cell & Tissue Engineering
Shiguo Yuan, Sheng Zheng, Kai Zheng, Yanping Gao, Meixiong Chen, Yikai Li, Xiaochun Bai
Summary: Sympathetic activity plays an important role in the proliferation and differentiation of stem cells, affecting skeletal muscle stem cell aging and repair. Clenbuterol can promote muscle injury repair and increase satellite cell number and sympathetic activity in aged and chemical sympathectomy mice, while its effects on young mice are not significant.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lola Torz, Kristoffer Niss, Sofia Lundh, Jens C. Rekling, Carlos Damian Quintana, Signe Emilie Dannulat Frazier, Aaron J. Mercer, Anda Cornea, Charlotte Vinther Bertelsen, Marina Kjaergaard Gerstenberg, Ann Maria Kruse Hansen, Mette Guldbrandt, Jens Lykkesfeldt, Linu Mary John, J. Carlos Villaescusa, Natalia Petersen
Summary: Restoring control of food intake is crucial for obesity management. NPFF has the potential to reduce food intake by inhibiting ARC NPY neurons, suggesting its therapeutic potential in obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kirsty Mcdowell, Carly Adamson, Colette Jackson, Ross Campbell, Paul Welsh, Mark C. Petrie, John J. V. Mcmurray, Pardeep S. Jhund, Neil Herring
Summary: The study found that higher levels of peripherally measured NPY in heart failure patients are associated with an increased risk of cardiovascular and all-cause death, even after adjusting for other potential prognostic factors such as BNP levels. However, higher NPY levels are not associated with an increased risk of heart failure hospitalization.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Neurosciences
Takahide Arai, Hideaki Kanazawa, Kensuke Kimura, Masahito Munakata, Hiroyuki Yamakawa, Ken Shinmura, Shinsuke Yuasa, Motoaki Sano, Keiichi Fukuda
Summary: Long-term emotional or physical stress may lead to stress cardiomyopathy and transient left ventricular ballooning, but the precise mechanisms are still unclear. In this study, researchers established an animal model of epilepsy-induced stress cardiomyopathy and found that neuropeptide Y (NPY) was upregulated in the cardiac sympathetic nerves and could interrupt beta-adrenergic signaling in cardiomyocytes, resulting in cardiac dysfunction.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Roberto B. Pontes, Erika E. Nishi, Renato O. Crajoinas, Maycon I. O. Milanez, Adriana C. C. Girardi, Ruy R. Campos, Cassia T. Bergamaschi
Summary: This study examined the effects of an acute increase in blood pressure and renal sympathetic nerve activity on sodium and water excretion and NHE3 activity. It was found that renal nerve stimulation independently decreased sodium and water excretion. However, when blood pressure was acutely increased during the stimulation, diuresis, natriuresis, and NHE3 activity inhibition were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Yvette Ruska, Anett Szilvasy-Szabo, Dora Kovari, Andrea Kadar, Lilla Macsai, Richard Sinko, Erik Hrabovszky, Balazs Gereben, Csaba Fekete
Summary: The study shows the presence of GLP-1 receptor (GLP-1R) protein and mRNA in orexigenic neuropeptide Y (NPY) neurons in the ventromedial arcuate nucleus, along with the innervation of NPY neurons by inhibitory neurons containing GLP-1R. This suggests that GLP-1 signaling can influence NPY neurons both directly and indirectly, revealing a more complex mechanism of GLP-1's effects on energy homeostasis.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Cell Biology
Ramon A. Pinol, Allison S. Mogul, Colleen K. Hadley, Atreyi Saha, Chia Li, Vojtech Skop, Haley S. Province, Cuiying Xiao, Oksana Gavrilova, Michael J. Krashes, Marc L. Reitman
Summary: The activation of POA(BRS3) neuronal populations increases body temperature, contributes to cold defense, and fine-tunes the feedback control of body temperature.
Article
Nutrition & Dietetics
Lei Wang, Shigetomo Suyama, Samantha A. A. Lee, Yoichi Ueta, Yutaka Seino, Geoffrey W. G. Sharp, Toshihiko Yada
Summary: Fasting can be used to treat obesity-related diseases, but it often leads to hyperphagia and weight rebound after re-feeding. This study reveals that fasting depresses synaptic transmission in the hypothalamic paraventricular nucleus (PVN) and activates the NPY-Y1R-oxytocin neurocircuit, resulting in acute hyperphagia. The intensity of fasting and the presence of hysteresis play important roles in the success of dieting.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Chen-Liang Zhang, Yi-Zhang Lin, Qi Wu, Chenxu Yan, Matthew Wai-Kin Wong, Fan Zeng, Ping Zhu, Kelsey Bowes, Kailun Lee, Xuan Zhang, Zhi-Yuan Song, Shu Lin, Yan-Chuan Shi
Summary: Chronic high salt intake is a leading cause of hypertension. This study demonstrates that high salt intake results in downregulation of NPY expression in the hypothalamic Arc and upregulation of BDNF and vasopressin expression in the PVN, leading to the development of hypertension.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Virginia L. Brooks, Zhigang Shi, Seth W. Holwerda, Paul J. Fadel
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2015)
Article
Physiology
Priscila A. Cassaglia, Zhigang Shi, Virginia L. Brooks
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2016)
Article
Peripheral Vascular Disease
Baoxin Li, Zhigang Shi, Priscila A. Cassaglia, Virginia L. Brooks
Article
Neurosciences
Zhigang Shi, Yueping Zhang, Johannes Meek, Jiantian Qiao, Victor Z. Han
JOURNAL OF COMPARATIVE NEUROLOGY
(2008)
Article
Neurosciences
Zhigang Shi, Virginia L. Brooks
JOURNAL OF PHYSIOLOGY-LONDON
(2015)
Article
Neurosciences
Priscila A. Cassaglia, Zhigang Shi, Baoxin Li, Wagner L. Reis, Nicholas M. Clute-Reinig, Javier E. Stern, Virginia L. Brooks
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Neurosciences
Y. Zhang, Z. Shi, G. Magnus, J. Meek, V. Z. Han, J. T. Qiao
Article
Neurosciences
Yu Zhang, Zhi-Gang Shi, Zhi-Hua Wang, Jian-Guo Li, Jin-Yuan Chen, Ce Zhang
NEUROSCIENCE LETTERS
(2014)
Article
Physiology
Zhigang Shi, Ding Zhao, Priscila A. Cassaglia, Virginia L. Brooks
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Biology
Zhigang Shi, Nicole E. Pelletier, Jennifer Wong, Baoxin Li, Andrei D. Sdrulla, Christopher J. Madden, Daniel L. Marks, Virginia L. Brooks
Meeting Abstract
Biochemistry & Molecular Biology
Christopher Madden, Zhigang Shi, Baoxin Li, Virginia Brooks
Meeting Abstract
Biochemistry & Molecular Biology
Zhigang Shi, Baoxin Li, Virginia Brooks
Meeting Abstract
Biochemistry & Molecular Biology
Zhigang Shi, Baoxin Li, Virginia L. Brooks
Meeting Abstract
Biochemistry & Molecular Biology
Y Zhang, ZG Shi, YM Kang, JT Qiao, C Zhang