Article
Multidisciplinary Sciences
Ying-Shao Lin, Ching-Kuan Liu, Hsiang-Chun Lee, Mei-Chuan Chou, Liang-Yin Ke, Chu-Huang Chen, Shiou-Lan Chen
Summary: The study found that long-term exposure to electronegative VLDL from patients with metabolic syndrome can lead to increased levels of inflammatory factors and amyloid beta in the brain, affecting cognitive function.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yuki Komatsu, Kiyoshi Aoyama, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Yumeno Kawai, Xixi Cui, Yuichiro Yamada, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata
Summary: The removal of interscapular brown adipose tissue (iBAT) attenuated the exacerbation of cardiac inflammation and fibrosis induced by salt loading in DS/obese rats, but did not affect the development of hypertension. Salt loading led to adipocyte hypertrophy and increased inflammation in white adipose tissue, while the conversion of iBAT to white adipose tissue-like tissue contributed to elevated levels of circulating interleukin-6, exacerbating cardiac pathology.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Food Science & Technology
Alana Carolina Costa Veras, Tamires dos Santos, Isis de Cassia Alves Martins, Camilla Mendes de Souza, Camila Libardi Amaral, Beatriz da Silva Franco, Alessandro Spencer de Souza Holanda, Andrea Maculano Esteves, Marciane Milanski, Adriana Souza Torsoni, Leticia Martins Ignacio-Souza, Marcio Alberto Torsoni
Summary: The study found that supplementation with a low dose of coconut oil can lead to anxious behavior, weight gain, and adiposity, as well as induce inflammatory responses in the brain and adipose tissue. Furthermore, at a low dose, coconut oil can also activate pro-inflammatory pathways through a TLR4-mediated mechanism.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Endocrinology & Metabolism
RuiYan Mei, WeiWei Qin, YanHua Zheng, Zhuo Wan, Li Liu
Summary: Exosomes secreted by adipose tissue play a crucial role in metabolic disorders, regulating specific mechanisms related to obesity, adipose inflammation, and diabetes. Adipose tissue is a major source of circulating exosomal miRNAs, which not only alter the state of patients with metabolic diseases but also affect the communication between metabolic organs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Ping-Song Chou, Sharon Chia-Ju Chen, Chung-Yao Hsu, Li-Min Liou, Chi-Hung Juan, Chiou-Lian Lai
Summary: L5, the most electronegative subfraction of LDL-C, may be associated with cognitive impairment through a disease stage-dependent mode that occurs during neurodegeneration. The study found a negative correlation between serum L5 levels and cognitive performance in patients with MCI, especially in the orientation and language subdomains. However, there was no significant correlation between serum L5 levels and cognitive performance in the control group.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fatima O. Martins, Joana F. Sacramento, Elena Olea, Bernardete F. Melo, Jesus Prieto-Lloret, Ana Obeso, Asuncion Rocher, Paulo Matafome, Emilia C. Monteiro, Silvia Conde
Summary: Several studies have shown a connection between obstructive sleep apnea (OSA) and insulin resistance. This study investigated the effects of chronic intermittent hypoxia (CIH) on metabolic deregulation and adipose tissue dysfunction, as well as the impact of obesity on CIH-induced metabolic disturbances. The results suggest that adipose tissue dysfunction may not be the main trigger for initial dysmetabolism in CIH.
Review
Food Science & Technology
William T. Festuccia
Summary: Evidence suggests that lipotoxicity and inflammation are key factors linking adipose tissue dysfunction to metabolic diseases, with mTOR playing a crucial role in regulating adipocyte and macrophage function. Studies reviewed here show that optimal levels of mTORC1 activity are necessary for lipogenic actions in adipocytes, while mTORC1 also regulates polarization in macrophages. On the other hand, mTORC2 promotes glucose uptake and lipogenesis in adipocytes while dampening macrophage inflammatory response.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Oscar Osorio-Conles, Arturo Vega-Beyhart, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Ana de Hollanda
Summary: The metabolic syndrome is a cluster of dangerous heart attack risk factors. This study compares the dysfunction of obesity-associated white adipose tissue (WAT) between women with severe obesity with or without metabolic syndrome. The results show that women with metabolic syndrome exhibit greater adipocyte hypertrophy, increased fibrosis, and higher expression of macrophage and hypoxia markers in subcutaneous adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Marina Chaves de Oliveira, Ana Leticia Malheiros Silveira, Amanda Carla Clemente de Oliveira, Jaqueline Pereira Lana, Katia Anunciacao Costa, Erica Leandro Marciano Vieira, Vanessa Pinho, Mauro Martins Teixeira, Fatiha Merabtene, Genevieve Marcelin, Karine Clement, Adaliene Versiani Matos Ferreira
Summary: This study evaluated the participation of eosinophils in metabolic and adipose tissue homeostasis in mice and humans, showing that eosinophils play a role in controlling systemic and adipose tissue metabolic homeostasis by modulating glucose metabolism, inflammation, and visceral fat expansion. These findings provide important insights into the pathogenesis of obesity and metabolic-related diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Biochemistry & Molecular Biology
Aimilia Eirini Papathanasiou, Fotios Spyropoulos, Zoe Michael, Kyoung E. Joung, Despina D. Briana, Ariadne Malamitsi-Puchner, Christos S. Mantzoros, Helen Christou
Summary: The study found significantly elevated levels of fatty acid binding protein 4, fibroblast growth factor-21, and adiponectin in the circulation of pulmonary hypertension patients, with increased mRNA levels of these metabolic regulators and PPAR γ gene in patient lung tissue. Experimental rodent models of PH and human patients demonstrated increased gene expression related to glucose uptake, glycolysis, tricarboxylic acid cycle, and fatty acid oxidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Lindsey J. Anderson, Jonathan Lee, Barbara Anderson, Benjamin Lee, Dorota Migula, Adam Sauer, Nicole Chong, Haiming Liu, Peter C. Wu, Atreya Dash, Yi-Ping Li, Jose M. Garcia
Summary: Cancer-related weight loss is associated with elevated levels of inflammation, lipolysis, and browning markers. BMI is associated with increased energy expenditure.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Endocrinology & Metabolism
Joerg Heeren, Ludger Scheja
Summary: MAFLD is characterized by pathological accumulation of triglycerides in hepatocytes and is closely related to disturbances in systemic energy metabolism. Liver plays a central role in lipid metabolism, with excessive hepatic triglyceride synthesis being a key factor in the development of MAFLD. Interventions targeting lipid storage and energy combustion in adipose tissues may help ameliorate MAFLD.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Sonia Benitez, Nuria Puig, Jose Rives, Arnau Sole, Jose Luis Sanchez-Quesada
Summary: Electronegative LDL (LDL(-)) is a minor form of LDL present in blood, which is increased in pathologies with increased cardiovascular risk. It has pro-atherogenic and anti-atherogenic properties, and can degrade different lipids due to its enzymatic activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that intraperitoneal VAT (IVAT) and retroperitoneal VAT (RVAT) are differently associated with the prevalence of metabolic syndrome (MS) and its components. IVAT area index was independently associated with MS and its components, while RVAT area index was only associated with the blood pressure component.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Afroditi Kastrenopoulou, Kyriakos E. Kypreos, Nicholaos Papachristou, Stavros Georgopoulos, Ioulia Mastora, Ioanna Papadimitriou-Olivgeri, Argyro Spentzopoulou, Dragana Nikitovic, Vassilios Kontogeorgakos, Harry C. Blair, Dionysios J. Papachristou
Summary: In this study, the researchers investigated the impact of APOA1 on bone marrow adipocytes using ApoA1 knockout mice. The results showed that APOA1 deficiency led to an increase in the number of adipocytes in the bone marrow, which resembled white adipocytes. Furthermore, the expression of brown/beige adipocyte-specific markers was reduced, and there was a decrease in the compartments of hematopoietic stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yu-Wen Kao, Sheng-Kai Hsu, Jeff Yi-Fu Chen, I-Ling Lin, Kuo-Jen Chen, Po-Yen Lee, Hui-Suan Ng, Chien-Chih Chiu, Kai-Chun Cheng
Summary: Curcumin, a valuable natural product with pharmacological activities, has low bioavailability, leading to challenges in its medicinal use. Recent studies focus on curcumin metabolites, particularly tetrahydrocurcumin (THC), and their potential protective effects against eye diseases. Further research is needed to explore the clinical application of curcumin in ophthalmic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ying-Shao Lin, Ching-Kuan Liu, Hsiang-Chun Lee, Mei-Chuan Chou, Liang-Yin Ke, Chu-Huang Chen, Shiou-Lan Chen
Summary: The study found that long-term exposure to electronegative VLDL from patients with metabolic syndrome can lead to increased levels of inflammatory factors and amyloid beta in the brain, affecting cognitive function.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Pei-Yu Chu, Hui-Wen Huang, Michittra Boonchan, Yu-Chang Tyan, Kevin Leroy Louis, Kun-Mu Lee, Kazushi Motomura, Liang-Yin Ke
Summary: The study aimed to establish an MS-based system for identifying and typing norovirus. Results showed that the LC/MSE system had an excellent coverage rate and could sensitively detect structural and functional mutations of noroviruses. This suggests that the use of LC/MSE may efficiently monitor genotypes of norovirus.
Article
Health Care Sciences & Services
Shih-Jie Jhuo, Tsung-Hsien Lin, Yi-Hsiung Lin, Wei-Chung Tsai, I-Hsin Liu, Bin-Nan Wu, Kun-Tai Lee, Wen-Ter Lai
Summary: This study demonstrated that treatment of type 2 diabetes mellitus patients with SGLT2 inhibitors could significantly reduce the incidence of total cardiac arrhythmia and atrial fibrillation, as well as decrease the risk of stroke, heart failure, and myocardial infarction. Additional investigations are needed to further confirm these findings.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dermatology
Ching-Han Tsao, Wei-Chen Hsieh, Feng-Jen Lin, Ri-Yao Yang, Meng-Ting Chang, Maria Karmella Apaya, Lie -Fen Shyur, Liang-Yin Ke, Christos C. Zouboulis, Fu-Tong Liu
Summary: Sebaceous glands produce lipids that are crucial for maintaining the skin barrier. Galectin-12 protein has been found to regulate sebocyte differentiation and lipid production, playing a positive role in sebaceous lipid metabolism.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shi-Hui Law, Hua-Chen Chan, Guan-Ming Ke, Swetha Kamatam, Gopal Kedihithlu Marathe, Vinoth Kumar Ponnusamy, Liang-Yin Ke
Summary: Despite the availability of cholesterol-lowering drugs, atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality. Lipid moieties such as lysophosphatidylcholine (LPC) and ceramide (CER) contribute to atherogenic events. The HFD-fed apoE(-/-) mouse model shows elevated LPC and CER contents, making it suitable for developing LPC- and CER-lowering therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shih-Jie Jhuo, Yi-Hsiung Lin, I-Hsin Liu, Tsung-Hsien Lin, Bin-Nan Wu, Kun-Tai Lee, Wen-Ter Lai
Summary: SGLT2 inhibitors have a protective effect on cardiomyocyte mitochondria, reducing ROS production and mitochondrial Ca2+ overload caused by high fat diet-induced metabolic disorder. They also increase ATP production, providing evidence and potential mechanisms for the benefit of SGLT2i in heart failure and arrhythmias.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Virology
Chia-Chi Cheng, Guan-Ming Ke, Pei-Yu Chu, Liang-Yin Ke
Summary: Norovirus is the leading cause of foodborne gastroenteritis, impacting millions of people worldwide annually. Different genotypes of norovirus exhibit post-translational modifications (PTMs) in their viral antigens, such as glycosylation and phosphorylation, which are associated with viral replication and virulence. Recent advancements in mass spectrometry have led to the discovery of more PTMs, contributing significantly to the prevention and treatment of infectious diseases. However, the mechanisms by which PTMs affect noroviruses are still not well understood. This section reviews the current knowledge on PTMs in noroviruses and their impact on pathogenesis, as well as the strategies and techniques for their identification.
Review
Oncology
Sheng-Kai Hsu, Mahendra Jadhao, Wei-Ting Liao, Wen-Tsan Chang, I-Ling Lin, Chien-Chih Chiu
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy that is often diagnosed at a late stage, leading to poor clinical outcomes despite advances in cancer therapeutics. Exosomes, small extracellular vesicles, have been found to have specific surface markers that can distinguish PDAC patients from healthy individuals. Detectable in various bodily fluids, exosomes hold promise as liquid biopsies for early detection and monitoring of PDAC. This review highlights the role of exosomes in PDAC progression and their potential as diagnostic and prognostic biomarkers.
Article
Pharmacology & Pharmacy
Ming-Jun Tsai, Wen-Yu Chang, I-Hui Chiu, I-Ling Lin, Pao-Chu Wu
Summary: The aim of this study was to develop a linalool-loaded microemulsion formulation for topical application. Statistical tools and experimental design were used to analyze the effect of formulation composition on the characteristics and permeation capacity of linalool-loaded microemulsion formulations and to obtain an appropriate drug-loaded formulation. The results showed that the droplet size, viscosity, and penetration capacity of linalool-loaded formulations were significantly affected by formulation component proportions. Specific microemulsion applications might be considered as potential drug delivery carriers for essential oil topical application.
Article
Virology
Po-Kai Chen, Jyun-Hao Chang, Liang-Yin Ke, Jun-Kai Kao, Chang-Hua Chen, Rei-Cheng Yang, Teruki Yoshimura, Etsuro Ito, Jih-Jin Tsai
Summary: A detection method for the NS1 protein based on an ultrasensitive ELISA was developed and evaluated, showing high sensitivity and specificity. This low-cost and easy-to-use method has great potential for clinical diagnosis of DENV, especially in low-income countries.
Article
Polymer Science
Muhammad Suhail, Chih-Wun Fang, I-Hui Chiu, Ming-Chia Hung, Quoc Lam Vu, I-Ling Lin, Pao-Chu Wu
Summary: The study proposed a novel aspartic acid-graft-poly(acrylic acid) hydrogel for the controlled release of acetaminophen. Through a series of experiments and tests, it was confirmed that the hydrogel exhibited high thermal stability and prolonged drug release. Additionally, the hydrogel demonstrated pH-responsive properties with excellent dynamic swelling and drug release performance.
Article
Polymer Science
Muhammad Suhail, I-Hui Chiu, Ming-Chia Hung, Quoc Lam Vu, I-Ling Lin, Pao-Chu Wu
Summary: This study synthesized chondroitin sulfate/sodium polystyrene sulfonate-co-poly(acrylic acid) hydrogels for the controlled release of ibuprofen. The pH-responsive hydrogel showed maximum swelling and drug release at pH 7.4. The structural arrangement, crosslinking, and thermal stability of the hydrogel were confirmed by various analyses.
Article
Biochemistry & Molecular Biology
Ching-Han Tsao, Wei-Chen Hsieh, Ri-Yao Yang, Yuan-Hsin Lo, Ting-Jui Tu, Liang-Yin Ke, Christos C. Zouboulis, Fu-Tong Liu
Summary: In this study, Galectin-12 was identified as an important intracellular regulator of sebocyte proliferation. It modulates cell cycle regulators and PPAR gamma expression to affect the proliferation of sebocytes. These findings suggest the potential of targeting Galectin-12 for the treatment of skin diseases related to sebaceous gland hyperfunction and androgens.
Article
Biochemistry & Molecular Biology
Akemi Kakino, Yoshiko Fujita, Liang-Yin Ke, Hua-Chen Chan, Ming-Hsien Tsai, Chia-Yen Dai, Chu-Huang Chen, Tatsuya Sawamura
Summary: Adiponectin has the ability to bind to and deactivate atherogenic LDL, thereby reducing its atherogenic effects by inhibiting LDL receptor endocytosis and cellular signaling pathways. This finding provides new insights into the antiatherogenic mechanisms of adiponectin.
JOURNAL OF LIPID RESEARCH
(2021)