期刊
JOURNAL OF CHEMICAL NEUROANATOMY
卷 83, 期 -, 页码 69-74出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchemneu.2017.01.004
关键词
3,4-methylenedioxypyrovalerone; Dopamine transporter; Amphetamine; Drosophila
资金
- NIH T-32 Training in the Pharmacological Sciences grant [4TR32GM007628-29]
- University School of Nashville Summer Grant
- National Institute on Drug Abuse grant [DA35263]
Synthetic cathinones are similar in chemical structure to amphetamines, and their behavioral effects are associated with enhanced dopaminergic signaling. The past ten years of research on the common constituent of bath salts, MDPV (the synthetic cathinone 3,4-methylenedioxypyrovalerone), has aided the understanding of how synthetic cathinones act at the dopamine (DA) transporter (DAT). Several groups have described the ability of MDPV to block the DAT with high-affinity. In this study, we demonstrate for the first time a new mode of action of MDPV, namely its ability to promote DATmediated DA efflux. Using single cell amperometric assays, we determined that low concentrations of MDPV (1 nM) can cause reverse transport of DA via DAT. Notably, administration of MDPV leads to hyperlocomotion in Drosophila melanogaster. These data describe further how MDPV acts at the DAT, possibly paving the way for novel treatment strategies for individuals who abuse bath salts. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据