Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling

(2016) Hu Wang et al.   Cell Stem Cell

Molecular model for force production and transmission during vertebrate gastrulation

(2016) Katherine Pfister et al.   DEVELOPMENT

Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages through positional changes

(2016) Yayoi Toyooka et al.   DEVELOPMENTAL BIOLOGY

Cell Division Drives Epithelial Cell Rearrangements during Gastrulation in Chick

(2016) Joao Firmino et al.   DEVELOPMENTAL CELL

Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly

(2016) Mo Weng et al.   JOURNAL OF CELL BIOLOGY

Tissue-specific designs of stem cell hierarchies

(2016) Jane E. Visvader et al.   NATURE CELL BIOLOGY

Stability of the hybrid epithelial/mesenchymal phenotype

(2016) Mohit Kumar Jolly et al.   Oncotarget

Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29

(2015) Carla Cicchini et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer

(2015) J A Galván et al.   BRITISH JOURNAL OF CANCER

BCL6 induces EMT by promoting the ZEB1-mediated transcription repression of E-cadherin in breast cancer cells

(2015) Jin-Mei Yu et al.   CANCER LETTERS

Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis

(2015) M. Ruscetti et al.   CANCER RESEARCH

ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program

(2015) Tuyen T. Dang et al.   CANCER RESEARCH

A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis

(2015) S.-H. Choi et al.   CLINICAL CANCER RESEARCH

Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation

(2015) P. Andre et al.   DEVELOPMENT

Epiblast morphogenesis before gastrulation

(2015) Guojun Sheng   DEVELOPMENTAL BIOLOGY

UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1

(2015) H.-J. Choi et al.   EMBO REPORTS

Vitiligo patient-derived keratinocytes exhibit characteristics of normal wound healing via epithelial to mesenchymal transition

(2015) Poulomi Banerjee et al.   EXPERIMENTAL DERMATOLOGY

MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4

(2015) Jun-Nian Zhou et al.   HEPATOLOGY

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation

(2015) Sylvain Bessonnard et al.   JOURNAL OF CELL BIOLOGY

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer

(2015) M E Buczek et al.   ONCOGENE

The invasive phenotype of placenta accreta extravillous trophoblasts associates with loss of E-cadherin

(2015) C.M. Duzyj et al.   PLACENTA

Ultrastructural visualization of the Mesenchymal-to-Epithelial Transition during reprogramming of human fibroblasts to induced pluripotent stem cells

(2015) M.K. Høffding et al.   Stem Cell Research

Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition

(2015) Hanbing An et al.   Oncotarget

Knockdown of CD44 inhibits the invasion and metastasis of hepatocellular carcinoma both in vitro and in vivo by reversing epithelial-mesenchymal transition

(2015) Yuan Gao et al.   Oncotarget

Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells

(2015) So-Yeon Park et al.   Oncotarget

Epithelial–Mesenchymal Transitions during Neural Crest and Somite Development

(2015) Chaya Kalcheim   Journal of Clinical Medicine

The side population of ovarian cancer cells defines a heterogeneous compartment exhibiting stem cell characteristics

(2015) Maximilian Boesch et al.   Oncotarget

Tumour-initiating capacity is independent of epithelial–mesenchymal transition status in breast cancer cell lines

(2014) G Xie et al.   BRITISH JOURNAL OF CANCER

Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels

(2014) M. A. Trembley et al.   DEVELOPMENT

Rho kinase activity controls directional cell movements during primitive streak formation in the rabbit embryo

(2014) V. Stankova et al.   DEVELOPMENT

Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation

(2014) R. B. Chalamalasetty et al.   DEVELOPMENT

iPS cells: a game changer for future medicine

(2014) H. Inoue et al.   EMBO JOURNAL

Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis

(2014) Matheus Correa-Costa et al.   LABORATORY INVESTIGATION

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

(2014) Mitsutoshi Yamada et al.   NATURE

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet

(2014) T. Yoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vertebrate Limb Bud Formation Is Initiated by Localized Epithelial-to-Mesenchymal Transition

(2014) J. Gros et al.   SCIENCE

Mesenchymal Stem Cell Priming: Fine-tuning Adhesion and Function

(2014) Dean P. J. Kavanagh et al.   Stem Cell Reviews and Reports

Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment

(2014) Yongshun Lin et al.   Nature Communications

Comparing ESC and iPSC—Based Models for Human Genetic Disorders

(2014) Tomer Halevy et al.   Journal of Clinical Medicine

Lack of Immune Response to Differentiated Cells Derived from Syngeneic Induced Pluripotent Stem Cells

(2013) Prajna Guha et al.   Cell Stem Cell

Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis

(2013) Megan Rowton et al.   DEVELOPMENTAL DYNAMICS

CTNNB1 in Mesenchyme Regulates Epithelial Cell Differentiation during Müllerian Duct and Postnatal Uterine Development

(2013) C. Allison Stewart et al.   MOLECULAR ENDOCRINOLOGY

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(2013) Hua Jiang et al.   MOLECULAR MEDICINE

Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming

(2013) Xiaopeng Liu et al.   NATURE CELL BIOLOGY

Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy

(2013) W. W. Hwang-Verslues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cells derived from murine induced pluripotent stem cells (iPSC) by treatment with members of TGF-beta family give rise to osteoblasts differentiation and form bone in vivo

(2012) Feng Li et al.   BMC CELL BIOLOGY

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

EMT and MET in Metastasis: Where Are the Cancer Stem Cells?

(2012) Thomas Brabletz   CANCER CELL

Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective

(2012) Gaoyang Liang et al.   CELL RESEARCH

Neural crest delamination and migration: From epithelium-to-mesenchyme transition to collective cell migration

(2012) Eric Theveneau et al.   DEVELOPMENTAL BIOLOGY

Early cell fate decisions in the mouse embryo

(2012) Néstor Saiz et al.   REPRODUCTION

Geminin Promotes an Epithelial-to-Mesenchymal Transition in an Embryonic Stem Cell Model of Gastrulation

(2012) Nicole Slawny et al.   STEM CELLS AND DEVELOPMENT

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

(2011) S. Goossens et al.   BLOOD

FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression

(2011) Katharine M Hardy et al.   BMC DEVELOPMENTAL BIOLOGY

Targeting ALDHbright Human Carcinoma-Initiating Cells with ALDH1A1-Specific CD8+ T Cells

(2011) C. Visus et al.   CLINICAL CANCER RESEARCH

Reciprocal Repression between Sox3 and Snail Transcription Factors Defines Embryonic Territories at Gastrulation

(2011) Hervé Acloque et al.   DEVELOPMENTAL CELL

Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice

(2011) Zhijie Xiao et al.   DEVELOPMENTAL DYNAMICS

Twist Modulates Human Trophoblastic Cell Invasion via Regulation of N-Cadherin

(2011) York Hunt Ng et al.   ENDOCRINOLOGY

Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition

(2011) Daniel J. Schneider et al.   FASEB JOURNAL

FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk

(2011) Patricia L. Martínez-Morales et al.   JOURNAL OF CELL BIOLOGY

Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

(2011) Momoko Maekawa et al.   NATURE

Human oocytes reprogram somatic cells to a pluripotent state

(2011) Scott Noggle et al.   NATURE

Expression of mesenchymal-related genes by the bovine trophectoderm following conceptus attachment to the endometrial epithelium

(2011) Sachiko Yamakoshi et al.   REPRODUCTION

Snail and the microRNA-200 Family Act in Opposition to Regulate Epithelial-to-Mesenchymal Transition and Germ Layer Fate Restriction in Differentiating ESCs

(2011) Jennifer G. Gill et al.   STEM CELLS

Concise Review: Induced Pluripotent Stem Cells Versus Embryonic Stem Cells: Close Enough or Yet Too Far Apart?

(2011) Josipa Bilic et al.   STEM CELLS

SIP1 Mediates Cell-Fate Decisions between Neuroectoderm and Mesendoderm in Human Pluripotent Stem Cells

(2010) Zhenzhi Chng et al.   Cell Stem Cell

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Epithelial to mesenchymal transition during gastrulation: An embryological view

(2010) Yukiko Nakaya et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Mechanisms of trophectoderm fate specification in preimplantation mouse development

(2010) Hiroshi Sasaki   DEVELOPMENT GROWTH & DIFFERENTIATION

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation

(2010) Jianguang Du et al.   DEVELOPMENTAL BIOLOGY

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells

(2010) Venkata Lokesh Battula et al.   STEM CELLS

The cessation of gastrulation

(2010) Sho Ohta et al.   Cell Adhesion & Migration

Aldehyde Dehydrogenase-Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer

(2009) J. E. Carpentino et al.   CANCER RESEARCH

Expression of an Exogenous Human Oct-4 Promoter Identifies Tumor-Initiating Cells in Osteosarcoma

(2009) P. P. Levings et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma

(2009) Myung Jin Son et al.   Cell Stem Cell

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

(2009) Hervé Acloque et al.   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin

(2009) Ofelia M Martínez-Estrada et al.   NATURE GENETICS

SNAI1 and SNAI2 Are Asymmetrically Expressed at the 2-Cell Stage and Become Segregated to the TE in the Mouse Blastocyst

(2009) Christine E. Bell et al.   PLoS One

p21CIP1attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

(2009) Manran Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABCG2 Expression and Side Population Abundance Regulated by a Transforming Growth Factor  -Directed Epithelial-Mesenchymal Transition

(2008) L. Yin et al.   CANCER RESEARCH

Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma

(2008) M. A. Harris et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Periodic Activation of Wnt/β-Catenin Signaling Enhances Somatic Cell Reprogramming Mediated by Cell Fusion

(2008) Frederic Lluis et al.   Cell Stem Cell

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation

(2008) Yukiko Nakaya et al.   NATURE CELL BIOLOGY