期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 233, 期 3, 页码 1897-1912出版社
WILEY
DOI: 10.1002/jcp.26017
关键词
cell signaling; inositol pyrophosphates; kinase; metabolism; phosphatase
资金
- Intramural Research Program of the NIH/National Institute of Environmental Health Sciences
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES080046] Funding Source: NIH RePORTER
Inositol pyrophosphates are small, diffusible signaling molecules that possess the most concentrated three-dimensional array of phosphate groups in Nature; up to eight phosphates are crammed around a six-carbon inositol ring. This review discusses the physico-chemical properties of these unique molecules, and their mechanisms of action. Also provided is information on the enzymes that regulate the levels and hence the signaling properties of these molecules. This review pursues the idea that many of the biological effects of inositol pyrophosphates can be rationalized by their actions at the interface of cell signaling and metabolism that is essential to cellular and organismal homeostasis.
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