Article
Nutrition & Dietetics
Freshta Amiry, Seyed Mohammad Mousavi, Ahmad Mujtaba Barekzai, Ahmad Esmaillzadeh
Summary: This study investigated the association between adherence to the Mediterranean dietary pattern (MD) and gastric cancer (GC) in Afghanistan. Results showed that higher MD scores were associated with a lower odds of GC, but this association disappeared after considering potential environmental factors, age, and sex. However, after further adjustment for BMI, participants with higher MD scores were significantly less likely to have GC.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Ying Zhou, Rishun Fu, Mei Yang, Weihuang Liu, Zan Tong
Summary: Lycopene, a natural carotenoid, inhibits the growth and induces apoptosis in gastric cancer cells. It decreases CCNE1 expression and increases the levels of TP53, making it a potential target therapy reagent for gastric cancer.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Hsueh-Han Tsai, Jyh-Cherng Yu, Huan-Ming Hsu, Chi-Hong Chu, Tzu-Ming Chang, Zhi-Jie Hong, An-Chieh Feng, Chun-Yu Fu, Kuo-Feng Hsu, Ming-Shen Dai, Guo-Shiou Liao
Summary: Breast cancer is a global public health problem and there is increasing interest in prevention strategies as its incidence rises. A healthy dietary pattern, such as the Mediterranean diet, with high levels of fiber, phytochemicals, antioxidants, and advantageous fatty acids, is considered a promising approach to reduce breast cancer risk. This review summarizes the important active compounds in preventing breast cancer, including polyunsaturated fatty acids, fiber, phytochemicals, and alcohol. While the exact mechanism is not well understood, the combination of these elements in a healthy diet plays a role in reducing breast cancer risk.
Article
Oncology
Zongze Jiang, Huilin Chen, Ming Li, Wei Wang, Feiwu Long, Chuanwen Fan
Summary: This study investigated the correlation between dietary tomato, tomato products, and lycopene intake and the incidence and mortality of colorectal cancer (CRC) in a US population. It found that high consumption of tomato salsa was significantly associated with a reduced risk of CRC incidence, but not with CRC mortality. However, the intake of raw tomatoes, tomato juice, tomato catsup, and lycopene showed no significant associations with CRC incidence or mortality. These findings suggest that tomato salsa consumption may have beneficial effects in preventing cancer, but further research is needed to evaluate its potential effects in other populations.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Ludovico Abenavoli, Anna Caterina Procopio, Maria Rosaria Paravati, Giosue Costa, Nataga Milic, Stefano Alcaro, Francesco Luzza
Summary: NAFLD is the most common chronic liver disease globally, with multiple factors contributing to its development. The Mediterranean diet and lycopene have shown beneficial effects in improving NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Qin Zhu, Long Shu, Feng Zhou, Li-Peng Chen, Yu-Liang Feng
Summary: This systematic review and meta-analysis summarized previous observational studies on the association between adherence to the Mediterranean diet and risk of gastric cancer. The findings suggest that high adherence to the Mediterranean diet is associated with a 29% reduced risk of gastric cancer.
FRONTIERS IN NUTRITION
(2023)
Article
Food Science & Technology
Brainer Vega-Lopez, Yendry Carvajal-Miranda, Laura Brenes-Peralta, Marianela Gamboa-Murillo, Jimmy Venegas-Padilla, Gerardo Rodriguez, Pablo Jimenez-Bonilla, Victor Alvarez-Valverde
Summary: In this study, we evaluated the compounds, antioxidant and antimicrobial activity of five tomato varieties grown in Costa Rica during ripening. The JR variety showed the highest concentration of lycopene, while variety 115 had the highest concentration of carotenoids and phenolic compounds.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Cell Biology
Xin Xu, Bo Xie, Shiqi Li, Shuo Wang, Dan Xia, Hongzhou Meng
Summary: The study found no statistically significant association between dietary intake of raw tomatoes, tomato catsup, tomato salsa, tomato juice, or lycopene and the risk of bladder cancer, based on analysis of the PLCO study data over a 12.5-year follow-up period.
Article
Nutrition & Dietetics
Ioanna Yiannakou, Martha R. Singer, Paul F. Jacques, Vanessa Xanthakis, R. Curtis Ellison, Lynn L. Moore
Summary: This study found that adherence to a Mediterranean-style diet is associated with a lower cancer risk, especially among women. Moderate or higher adherence to the MSDP can significantly decrease the risk of cancer.
Article
Agronomy
Pasquale Tripodi, Rosa Pepe, Gianluca Francese, Macellaro Rosaria, Vincenzo Onofaro Sanaja, Carlo Di Cesare, Giovanna Festa, Antonietta D'Alessandro, Giuseppe Mennella
Summary: This study conducted a comprehensive assessment of the morphological and biochemical traits of twenty-one accessions of two landraces, 'Re Fiascone' and 'San Marzano', from the Campania region in Southern Italy. Fruit morphology and content of sugars and flavonoids were identified as the most discriminating parameters among cultivars. The levels of sugars, organic acids, and antioxidants like ascorbic acid, as well as molecular analysis using microsatellite genotyping, were also studied in order to identify unique traits and potential for breeding programs.
Review
Nutrition & Dietetics
Gonzalez-Palacios Torres Carla, Rocio Barrios-Rodriguez, Carlos Munoz-Bravo, Estefania Toledo, Trinidad Dierssen, Juan Jimenez-Moleon Jose
Summary: This umbrella review summarized the available evidence on the relationship between Mediterranean Diet and breast cancer risk. The results indicate that adherence to a Mediterranean Diet pattern can have a protective effect on breast cancer risk, especially for postmenopausal breast cancer.
CLINICAL NUTRITION
(2023)
Article
Agronomy
Ioanna Kakabouki, Antigolena Folina, Aspasia Efthimiadou, Stella Karydogianni, Charikleia Zisi, Varvara Kouneli, Nikolaos C. Kapsalis, Nikolaos Katsenios, Ilias Travlos
Summary: This study found that blending tomato pomace with organic fertilizers in tomato cultivation not only improved soil quality but also increased yield.
Article
Food Science & Technology
J. Y. Mendez-Carmona, J. A. Ascacio-Valdes, Olga B. Alvarez-Perez, Ayerim Y. Hernandez-Almanza, Nathiely Ramirez-Guzman, Leonardo Sepulveda, Miguel A. Aguilar-Gonzalez, Janeth M. Ventura-Sobrevilla, Cristobal N. Aguilar
Summary: Tomato waste contains important bioactive molecules that have potential applications in the food, pharmaceutical, biotechnological, and cosmetic industries. However, challenges remain in terms of the quality of extracted compounds, economic accessibility, industrial reproducibility, and environmental safety during the extraction and recovery process.
Review
Chemistry, Applied
Ni Li, Xiaoting Wu, Wen Zhuang, Lin Xia, Yi Chen, Chuncheng Wu, Zhiyong Rao, Liang Du, Rui Zhao, Mengshi Yi, Qianyi Wan, Yong Zhou
Summary: This study aimed to clarify the associations between tomato and lycopene and multiple health outcomes. The intake of tomato and lycopene was shown to have protective effects against various diseases.
Review
Nutrition & Dietetics
Emmanouil Bouras, Konstantinos K. Tsilidis, Marianthi Triggi, Antonios Siargkas, Michail Chourdakis, Anna-Bettina Haidich
Summary: In this Umbrella Review, the study provides an overview and evaluation of the associations of diet-related exposures with the risk of gastric cancer. The findings suggest that heavy alcohol consumption, salted fish consumption, high waist circumference, and unhealthy lifestyle choices are positively associated with gastric cancer, while maintaining a normal body weight and adopting a healthy lifestyle can reduce the risk. The quality of most meta-analyses included in the review is medium-to-high.
Review
Cell Biology
Pierluigi Scalia, Stephen J. Williams, Yoko Fujita-Yamaguchi, Antonio Giordano
Summary: The IGFs are important growth factors that play a key role in cell growth and cell cycle progression through their cellular receptors. Understanding the intracellular signaling mechanisms of IGFs is crucial for cancer research. This study provides a comprehensive summary of the current understanding of the regulatory mechanisms of IGFs in cancer and suggests new perspectives for further research.
Article
Anatomy & Morphology
Ilenia Severi, Silvia Abbatelli, Jessica Perugini, Eleonora Di Mercurio, Martina Senzacqua, Antonio Giordano
Summary: This study is the first comprehensive morphological investigation into the distribution and physiological role of BChE in the mouse gastrointestinal tract. BChE-positive cells were found in various digestive organs, such as the stomach, liver, and intestine, and were closely linked to ghrelin production.
JOURNAL OF ANATOMY
(2023)
Article
Medicine, General & Internal
Antonio Tufano, Nadia Cordua, Valerio Nardone, Raffaele Ranavolo, Rocco Simone Flammia, Federica D'Antonio, Federica Borea, Umberto Anceschi, Costantino Leonardo, Andrea Morrione, Antonio Giordano
Summary: This study investigated the prognostic value of site-specific metastases in patients with metastatic upper tract urothelial carcinoma (mUTUC) and its association with survival outcomes. The results showed that distant lymph nodes were the most common site of single-organ metastasis in mUTUC patients. Patients with liver metastases and multiple organ metastases had worse survival outcomes. Additionally, chemotherapy and radical nephroureterectomy (RNU) were identified as predictors of better survival outcomes in mUTUC patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Marcella Barbarino, Maria Bottaro, Laura Spagnoletti, Maria Margherita de Santi, Raffaella Guazzo, Chiara Defraia, Cosimo Custoza, Gabriella Serio, Francesco Iannelli, Matilde Pesetti, Raffaele Aiello, Diletta Rosati, Edoardo Zanfrini, Luca Luzzi, Cristiana Bellan, Antonio Giordano
Summary: Primary cilium is a cellular organelle found on almost all mammalian cells, which transduces signals and regulates various physiological pathways. Dysfunction in primary cilium is associated with pathologic conditions including cancer. This study focused on the role of primary cilium in the Hedgehog signaling pathway in malignant pleural mesothelioma (MPM) and uncovered evidence of a PC-independent regulation of Hh signaling in MPM.
Article
Cell Biology
Antonio C. Pagano Zottola, Ilenia Severi, Astrid Cannich, Philippe Ciofi, Daniela Cota, Giovanni Marsicano, Antonio Giordano, Luigi Bellocchio
Summary: By activating the CB1 receptor, cannabinoids regulate mitochondrial physiology and energy metabolism in adipocytes through intracellular signaling pathways.
Review
Biochemistry & Molecular Biology
Giovanni Ciccarelli, Stefano Conte, Giovanni Cimmino, Patrizia Maiorano, Andrea Morrione, Antonio Giordano
Summary: Atherosclerosis is a complex disease involving metabolic processes and inflammation. Despite improved therapies, a significant residual risk remains due to unmet therapeutic targets. Endothelial dysfunction and lipid infiltration are primary causes of atherosclerotic plaque progression. Mitochondrial dysfunction can affect arterial wall cells, leading to oxidative stress, chronic inflammation, and intracellular lipid deposition. Evaluating mitochondrial defects through the detection and characterization of mitochondrial DNA (mtDNA) is crucial, and mitochondria-targeting therapies show promise in treating atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Carlo Francesco Morelli, Adele Cutignano, Giovanna Speranza, Gennaro Roberto Abbamondi, Marco Rabuffetti, Carmine Iodice, Rocco De Prisco, Giuseppina Tommonaro
Summary: There is a strong need to develop eco-sustainable agricultural techniques to improve crop yields while preserving biomolecule contents and reducing the adverse environmental impact of agro-chemicals. The use of microorganisms in agriculture represents an attractive and innovative solution. This study provides chemical data in support of the use of effective microorganisms (EM) green technology for the cultivation of edible agricultural products, such as tomato preserves, and may even improve nutritional and sensory qualities while safeguarding the environment.
Article
Chemistry, Medicinal
Giuseppina Tommonaro, Debora Paris, Giulia Guerriero, Fatima-Zahra Majdoubi, Gaetano Grieco, Carmine Iodice, Lucio Caso, Anouar Ouizgane, Aziz El Moujtahid, Sara El Ghizi, Meriem Bousseba, Mustapha Hasnaoui, Annalaura Iodice, Annabella Tramice
Summary: Fishes are a valuable source of essential fatty acids for preventing cardiovascular diseases. However, the increase in fish consumption has led to a rise in fish waste, making waste disposal and recycling an important issue in line with circular economy principles. This study investigated the fatty acid profiles of different fish tissues and found that fish waste, such as liver and ovary, could be a sustainable source of high value-added nutraceuticals.
Review
Oncology
Elisa Ventura, Giacomo Ducci, Reyes Benot Dominguez, Valentina Ruggiero, Antonino Belfiore, Elena Sacco, Marco Vanoni, Renato V. V. Iozzo, Antonio Giordano, Andrea Morrione
Summary: Progranulin plays an important pro-tumorigenic role in various solid tumors and has diagnostic and prognostic values in multiple tumor types. The molecular mechanisms underlying progranulin's function in cancer are not fully understood, but recent evidence suggests a strong context-dependency of progranulin signaling. This review focuses on summarizing the current evidence supporting the pro-oncogenic role of progranulin and its molecular mechanisms of action in cancer.
Review
Cell Biology
Riccardo Di Fiore, Sherif Suleiman, Rosa Drago-Ferrante, Yashwanth Subbannayya, Sarah Suleiman, Mariela Vasileva-Slaveva, Angel Yordanov, Francesca Pentimalli, Antonio Giordano, Jean Calleja-Agius
Summary: The FBXW7 protein plays a role in regulating cellular growth and acts as a tumor suppressor. It is a component of the SCF complex and aids in the degradation of oncoproteins via the UPS. FBXW7 mutations are associated with cancer and could potentially serve as diagnostic and prognostic biomarkers. This review aims to provide an update on the role of FBXW7 as a potential biomarker and therapeutic target, particularly in gynecologic cancers.
Article
Cell Biology
Michele d'Angelo, Laura Brandolini, Mariano Catanesi, Vanessa Castelli, Cristina Giorgio, Margherita Alfonsetti, Mara Tomassetti, Mara Zippoli, Elisabetta Benedetti, Maria Candida Cesta, Sandro Colagioia, Pasquale Cocchiaro, Annamaria Cimini, Marcello Allegretti
Summary: Intestinal barrier disruption can lead to leaky gut, characterized by loss of epithelial integrity. Non-steroidal anti-inflammatory drugs (NSAIDs) are known to have harmful effects on intestinal and gastric epithelial integrity. This study compared the effects of different classes of NSAIDs in an in vitro model of leaky gut. The results showed that ketoprofen and ketoprofen lysine salt counteracted oxidative stress and morphological changes in the intestinal barrier, while ibuprofen and its salts had similar effects.
Review
Agriculture, Dairy & Animal Science
Giovanna Liguori, Anna Costagliola, Renato Lombardi, Orlando Paciello, Antonio Giordano
Summary: Animal-assisted interventions (AAIs) are planned activities carried out in multidisciplinary teams with educational, therapeutic, and recreational purposes. These interventions offer many advantages to subjects but may expose them to zoonotic-pathogen transmission. Therefore, ensuring positive animal welfare and implementing preventive measures are crucial for the safety of patients.
Article
Developmental Biology
Carmine Merola, Giulia Caioni, Annamaria Cimini, Monia Perugini, Elisabetta Benedetti
Summary: This study evaluated the impact of sodium valproate (SV) on zebrafish early-life stages and found that SV has teratogenic potential, causing morphological abnormalities in the head and body of zebrafish, as well as significant malformations in the brain. Additionally, the study suggests a potential protective role of pparg in SV dose-dependent toxicity, which is reported for the first time.
BIRTH DEFECTS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Francesco D'Egidio, Vanessa Castelli, Annamaria Cimini, Michele d'Angelo
Summary: Huntington's Disease (HD) is a hereditary neurodegenerative disorder caused by the expansion of a CAG triplet repeat in the HTT gene, resulting in the production of an aberrant huntingtin (Htt) protein. The accumulation of mutant protein leads to neuronal dysfunction and cell death, primarily through oxidative damage, excitotoxicity, inflammation, and mitochondrial impairment. This review aims to provide an overview of the cell's response to stress in HD, with a focus on the role of oxidative stress and its interaction with the antioxidant system.
Review
Biochemistry & Molecular Biology
Alfredo Caturano, Margherita D'Angelo, Andrea Mormone, Vincenzo Russo, Maria Pina Mollica, Teresa Salvatore, Raffaele Galiero, Luca Rinaldi, Erica Vetrano, Raffaele Marfella, Marcellino Monda, Antonio Giordano, Ferdinando Carlo Sasso
Summary: Oxidative stress plays a critical role in the development and progression of diabetes and its associated complications. The imbalance between reactive oxygen species (ROS) production and the body's antioxidant defense mechanisms leads to cellular damage and dysfunction. By understanding and addressing oxidative stress, it may be possible to alleviate the burden of diabetes and improve patient outcomes.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
