Dedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development

Dedicator of Cytokinesis 2, A Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling

(2015) X. Guo et al.   CIRCULATION RESEARCH

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

(2015) Kerry Dobbs et al.   NEW ENGLAND JOURNAL OF MEDICINE

Essential Role of Elmo1 in Dock2-Dependent Lymphocyte Migration

(2014) C. Stevenson et al.   JOURNAL OF IMMUNOLOGY

The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation

(2013) Y. Sakai et al.   BLOOD

Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease

(2013) Patrick J. Cimino et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2

(2013) K. Yasuda et al.   INTERNATIONAL IMMUNOLOGY

Annular PIP 3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse

(2013) Audrey Le Floc’h et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2

(2012) Akihiko Nishikimi et al.   CHEMISTRY & BIOLOGY

Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function

(2012) David García-Bernal et al.   JOURNAL OF PATHOLOGY

Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration

(2012) Masao Terasawa et al.   PLoS One

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

(2012) K. Hanawa-Suetsugu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses

(2012) W. E. Purtha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation

(2011) C. P. El-Haibi et al.   CELL PROLIFERATION

Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors

(2011) Kiran Kulkarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ASCertaining cytoskeletal rearrangements in antigen presentation and migration

(2011) Ioannis Karakasiliotis et al.   NATURE IMMUNOLOGY

The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization

(2011) Sirish K Ippagunta et al.   NATURE IMMUNOLOGY

Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune Responses

(2011) Hoda Hassan et al.   TheScientificWorldJOURNAL

DOCK2 regulates cell proliferation through Rac and ERK activation in B cell lymphoma

(2010) Lei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation

(2010) Kazuhito Gotoh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells

(2010) Christelle P El Haibi et al.   Molecular Cancer

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

DOCK2 Is a Microglial Specific Regulator of Central Nervous System Innate Immunity Found in Normal and Alzheimer’s Disease Brain

(2009) Patrick J. Cimino et al.   AMERICAN JOURNAL OF PATHOLOGY

CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway

(2009) K. Gollmer et al.   BLOOD

Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion

(2009) Shailesh Singh et al.   CANCER LETTERS

Rac1 GTPase: A “Rac” of All Trades

(2009) E. E. Bosco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines

(2009) Shailesh Singh et al.   INTERNATIONAL JOURNAL OF CANCER

Selective blockade of PGE2 EP1 receptor protects brain against experimental ischemia and excitotoxicity, and hippocampal slice cultures against oxygen-glucose deprivation

(2009) Abdullah Shafique Ahmad et al.   NEUROTOXICITY RESEARCH

CELL BIOLOGY: Two Lipids That Give Direction

(2009) J.-F. Cote et al.   SCIENCE

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

(2009) A. Nishikimi et al.   SCIENCE

Dock2 participates in bone marrow lympho-hematopoiesis

(2008) Tomoko Kikuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells

(2008) K. Gotoh et al.   BLOOD

The role of CXC chemokines and their receptors in cancer

(2008) Jo Vandercappellen et al.   CANCER LETTERS

Parallel Phosphatidylinositol 3-Kinase (PI3K)-dependent and Src-dependent Pathways Lead to CXCL8-mediated Rac2 Activation and Chemotaxis

(2008) Jiqing Sai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis

(2008) W. Su et al.   MOLECULAR PHARMACOLOGY

How chemokines invite leukocytes to dance

(2008) Marcus Thelen et al.   NATURE IMMUNOLOGY