Review
Genetics & Heredity
Yu Shi, Zihao Liu, Qun Lin, Qing Luo, Yinghuan Cen, Juanmei Li, Xiaolin Fang, Chang Gong
Summary: The study of miRNA in cancer has made significant advancements, with research showing that miRNA can be dysregulated in different types of cancers and act as either tumor promoters or tumor suppressors. Studies have also revealed that miRNA may serve as novel tools and targets for therapeutic attempts, and the development of miRNA delivery systems has accelerated the preclinical implications of miRNA in cancer treatment.
Review
Biochemistry & Molecular Biology
Yi-Fang Yang, Chien-Hsiu Li, Huei-Yu Cai, Bo-Syuan Lin, Cheorl-Ho Kim, Yu-Chan Chang
Summary: Cellular metabolism regulates physiological mechanisms and homeostasis in an individual. Abnormal metabolic reprogramming, caused by various factors such as gene mutations and epigenetic modifications, is associated with the development of diseases, including cancer. Metabolism-related molecules can serve as markers or prevention targets for cancer progression. Translational medicines using metabolic substrates and precursors have been developed for imaging and therapeutic purposes. Isotopically labeled compounds can be used to localize and visualize tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Ge Zhang, Hua-Rong Ye, Yao Sun, Zhen-Zhong Guo
Summary: Ultrasound contrast agents have been widely used in ultrasound molecular cancer imaging to improve the detection and characterization of tumors. This review provides an overview of the various types of contrast agents used in ultrasound molecular imaging and discusses their recent development and future perspectives.
Article
Chemistry, Analytical
Bingqian Li, Shengrong Yu, Rong Feng, Zhiling Qian, Kangdi He, Guo-Jiang Mao, Yuting Cao, Keqi Tang, Ning Gan, Yong-Xiang Wu
Summary: Bioimaging, including fluorescence imaging, is widely used in modern medicine. However, one-photon fluorescence imaging has limitations such as low tissue penetration depth and low spatiotemporal resolution. Two-photon fluorescence imaging can overcome these limitations, but the complexity of organisms can affect the accuracy of results. Fluorescence lifetime imaging (FLIM) is an intrinsic property of materials and independent of material concentration and fluorescence intensity, making it a promising alternative. By combining silica-coated gold nanoclusters (AuNCs@SiO2) with nucleic acid probes, a dual-mode nanoprobe platform for two-photon and FLIM imaging of intracellular miRNA-21 was constructed. The dual-mode nanoprobe exhibited high sensitivity and selectivity, with potential applications in miRNA-based early detection and therapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jeanne P. Uyisenga, Ahmed Debit, Christophe Poulet, Pierre Freres, Aurelie Poncin, Jerome Thiry, Leon Mutesa, Guy Jerusalem, Vincent Bours, Claire Josse
Summary: The study evaluated the diagnostic performance of circulating microRNAs in breast cancer in populations from Belgium and Rwanda, finding that while there is no universal circulating signature, specific signatures can be identified for different populations.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Alti Dayakar, Kumar D. Shanmukha, Suresh K. Kalangi
Summary: This article reviews the regulation, functions, and potential applications of miRNAs in cancer. The study of miRNA and its target genes can provide new approaches and strategies for the diagnosis, treatment, and prognosis of cancer.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Sha Yu, Yao Sun, Jingyi Cai, Yuanzhen Zhou, Jun-Jie Zhu
Summary: An acid-driven separable nanodevice has been developed for multilayer imaging of diverse biomarkers with different spatial distributions in living cells. This nanodevice allows simultaneous in situ imaging of intracellular microRNAs and extracellular pH, providing a new approach for developing a precise imaging system for disease diagnosis.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Physical
Changrong Shi, Zijian Zhou, Hongyu Lin, Jinhao Gao
Summary: This review focuses on the current development of advanced imaging technologies aiming to predict the treatment response in cancer therapy, with special interest in systems that provide rapid and noninvasive assessment of pharmacokinetics and tumor microenvironment. It also provides an overview of the emerging artificial intelligence technology and machine learning in medical imaging applications, discussing the current status, practical significance, and future challenges. Ultimately, the authors hope that this review will inspire research interest in molecular imaging and precision medicine.
Article
Nanoscience & Nanotechnology
Linlin Ren, Chengfang Jiang, Yuqi Zhang, Mengmeng Li, Yan Zhang, Xinli Shi, Qi Wang, Shusheng Zhang, Xinyue Song
Summary: A near-infrared light-controlled DNA nanomachine was constructed for highly sensitive imaging of intracellular microRNA in cancer cells, and it can also perform precise photodynamic therapy on tumors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Endocrinology & Metabolism
Jing Li, Yingjie Zhang, Fenghao Sun, Ligang Xing, Xiaorong Sun
Summary: This article summarizes the molecular mechanisms of dedifferentiation in thyroid cancer and combines it with early detection through molecular modification-based imaging to provide more accurate diagnosis and novel therapeutic approaches for managing dedifferentiated thyroid cancer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tudor Moisoiu, Mihnea P. Dragomir, Stefania D. Iancu, Simon Schallenberg, Giovanni Birolo, Giulio Ferrero, Dan Burghelea, Andrei Stefancu, Ramona G. Cozan, Emilia Licarete, Alessandra Allione, Giuseppe Matullo, Gheorghita Iacob, Zoltan Balint, Radu I. Badea, Alessio Naccarati, David Horst, Barbara Pardini, Nicolae Leopold, Florin Elec
Summary: By combining microRNA analysis and surface-enhanced Raman spectroscopy, a non-invasive, point-of-care diagnostic and molecular stratification tool for bladder cancer can be developed.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xiaoxue Cheng, Xiaosong Li, Yuexi Kang, Decai Zhang, Qiubo Yu, Junman Chen, Xinyu Li, Li Du, Tiantian Yang, Yao Gong, Ming Yi, Songzhi Zhang, Shasha Zhu, Shijia Ding, Wei Cheng
Summary: This study proposes a new strand displacement reaction model to enhance the efficiency of RNA in situ imaging. The approach allows for monitoring changes in gene expression within cells and holds potential value for clinical applications.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Jinho Yoon, Minkyu Shin, Ji-Young Lee, Sang-Nam Lee, Jin-Ha Choi, Jeong-Woo Choi
Summary: RNA interference (RNAi)-based therapeutics have not been used for cancer treatment due to their instability and microRNA (miRNA) delivery challenges. Plasmonic nanoparticle-based RNAi nanotherapeutics have been developed with specific properties for accurate cancer diagnosis and strong therapeutic effects. This review presents recent strategies and advances in plasmonic nanoparticle-based miRNA delivery for cancer detection and treatment, and discusses the challenges and potential opportunities in the field of RNAi-based theragnosis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Malgorzata Guz, Witold Jeleniewicz, Marek Cybulski
Summary: The role of non-coding RNAs (ncRNAs) in cancer is undeniable. Aberrant expression of ncRNAs, including circular RNAs (circRNAs) and microRNAs (miRNAs), is involved in the molecular mechanisms of carcinogenesis. CircRNAs, as a part of the competing endogenous RNA (ceRNAs) network, play a central role in regulating the accessibility of miRNAs to their mRNA targets. The imbalance between circRNAs and miRNAs is crucial in various pathologies, including cancer. This review focuses on the interaction between circRNAs and miR-141, a well-known member of the miR-200 family, in malignant transformation, highlighting the biological role of circRNA/miR-141/mRNA networks as a potential target for future anti-cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Roberto Piergentili, Giuseppe Basile, Cristina Nocella, Roberto Carnevale, Enrico Marinelli, Renato Patrone, Simona Zaami
Summary: Although the discovery of non-coding RNAs (ncRNAs) dates back to 1958, it is only recently that the complexity of the transcriptome has started to be understood. The identification and function of these ncRNAs are still under investigation, but they are known to play a regulatory role in gene expression. This review summarizes the current knowledge on these mechanisms, their potential use in disease treatment, and the challenges and ethical issues associated with their use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Mohammad Ali Nilforoushzadeh, Amir Raoofi, Hamideh Afzali, Omid Gholami, Sona Zare, Davood Nasiry, Ebrahim Khodaverdi Darian, Auob Rustamzadeh, Shiva Alavi, Rahim Ahmadi, Alimohammad Alimohammadi, Zahra Razzaghi, Zahra Safaie Naraghi, Mona Mahmoudbeyk, Mohammad Amir Amirkhani, Amin Mousavi Khaneghah
Summary: This study investigated the benefits of Wharton's jelly mesenchymal stem cells (WJ-MSCs) derived from the human umbilical cord in wound healing in diabetic rats. The results showed that the WJ-MSCs group had significantly higher wound closure, thickness, and density of new epidermis and dermis, as well as skin elasticity compared to the control group. This suggests that subcutaneous administration of WJ-MSCs can effectively accelerate healing and be used alongside other treatment methods for chronic wounds.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Cell Biology
Ali Karimi Sisakht, Mohammad Malekan, Farbod Ghobadinezhad, Seyedeh Negar Mousavi Firouzabadi, Ameneh Jafari, Seyed Mohammad Ali Mirazimi, Banafshe Abadi, Rana Shafabakhsh, Hamed Mirzaei
Summary: Glioblastoma (GBM) is a highly malignant brain tumor with poor prognosis. The communication between glioblastoma cells and their microenvironment plays a critical role in tumor progression, angiogenesis, metastasis, immune suppression, and treatment resistance. Understanding these communication routes could lead to the development of novel therapeutic strategies against GBM.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, General & Internal
Nader Molavi, Morad Rasouli-Azad, Hamed Mirzaei, Amir Hassan Matini, Hamid Reza Banafshe, Marjan Valiollahzadeh, Majid Hassanzadeh, Ahmad Reza Saghazade, Samira Abbaszadeh-Mashkani, Peyman Mamsharifi, Amir Ghaderi
Summary: The study showed that probiotic treatment in patients receiving MMTPs significantly improved symptoms of depression, reduced blood glucose, cholesterol, and LDL cholesterol levels, as well as decreased inflammation. Probiotics also increased total antioxidant capacity and total glutathione levels.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Review
Biology
Anis Javadi, Mohammad Reza Nikhbakht, Javad Ghasemian Yadegari, Auob Rustamzadeh, Mohsen Mohammadi, Alireza Shirazinejad, Saleh Azadbakht, Zahra Abdi
Summary: The study focuses on the radioactive role of natural and chemical substances on human and animal subjects. It is found that radiation exposure can lead to the production of reactive oxygen species (ROS), causing damage to DNA and body tissues when the body's antioxidant systems are insufficient to neutralize free radicals. Therefore, the use of alternative substances to reduce and inhibit free radicals is necessary.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amir Raoofi, Ali Delbari, Davood Nasiry, Rahim Golmohammadi, Sara sadat Javadinia, Reza Sadrzadeh, Mohammad-Shafi Mojadadi, Auob Rustamzadeh, Amin Mousavi Khaneghah, Vahid Ebrahimi, Mohammad Jafar Rezaie
Summary: In this study, it was found that administration of caffeine can alleviate damage to the cerebellum caused by tramadol, demonstrating its neuroprotective effects.
JOURNAL OF CHEMICAL NEUROANATOMY
(2022)
Review
Genetics & Heredity
Sara Ahmadpour, Tarannomsadat Taghavi, Amirhossein Sheida, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Hamed Mirzaei
Summary: Glioma is a common invasive primary tumor of the central nervous system, and treatment resistance remains a problem. Non-coding RNAs play a role in the mechanisms of treatment resistance. This review discusses the pathways by which microRNAs and long non-coding RNAs affect resistance to chemotherapy and radiotherapy, and offers potential therapeutic options for future glioma treatment.
Article
Dermatology
Mohammad Ali Nilforoushzadeh, Hamideh Afzali, Amir Raoofi, Maryam Nouri, Reza Naser, Omid Gholami, Davood Nasiry, Abdolreza Mohammadnia, Zahra Razzaghi, Alimohammad Alimohammadi, Zahra Safaie Naraghi, Aisan Peyrovan, Faeze Jahangiri, Ebrahim Khodaverdi Darian, Auob Rustamzadeh, Sona Zare
Summary: This study evaluated the effectiveness of using cell spray for the healing of diabetic wounds in rats through clinical, pathological, and biometric parameters. The results showed that the application of cell spray significantly accelerated the healing of diabetic wounds on Days 7, 14, and 21.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Correction
Neurosciences
Amir Hossein Mohammadi, Seyedvahid Seyedmoalemi, Mahsa Moghanlou, Seyed Amirreza Akhlagh, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Ameneh Jafari, Hamed Mirzaei
MOLECULAR NEUROBIOLOGY
(2022)
Review
Oncology
Amirhossein Davoodvandi, Sahand Sadeghi, Seyed Mohammad Amin Alavi, Seyedeh Shaghayegh Alavi, Ameneh Jafari, Haroon Khan, Michael Aschner, Hamed Mirzaei, Mehran Sharifi, Zatollah Asemi
Summary: Cancer is a serious health issue and drug therapy is commonly used for treatment. There is increasing interest in using natural compounds to overcome drug resistance and adverse reactions in cancer treatment. One such compound is berberine, which has a wide range of pharmacological activities and has shown anticancer effects on various gastrointestinal cancers. In this article, the therapeutic effects of berberine and its mechanisms on esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers are summarized.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Neurosciences
Mehran Ebrahimi Shah-abadi, Armin Ariaei, Fatemeh Moradi, Auob Rustamzadeh, Rastegar Rahmani Tanha, Nader Sadigh, Mohsen Marzban, Mahdi Heydari, Vahid Tavakolian Ferdousie
Summary: Memory impairment is caused by factors such as Aβ accumulation and the involvement of various receptors and blood lipids in Aβ signaling pathway. Molecular docking and dynamics analyses identified silymarin as a potential inhibitor of AChE, P-glycoprotein, and ACE2. Rosuvastatin and quercetin were found to be more stable than silymarin and donepezil in complex with P-glycoprotein and ACE2, respectively.
NEUROTOXICITY RESEARCH
(2023)
Article
Chemistry, Medicinal
Mohammad Jaber MasodKhooy, Massoumeh Farasat, Mohamadreza Salehi Salmi, Hamed Mirzaei
Summary: This study evaluated the antitumor effect of a combination of Silybum marianum essential oils and 5-fluorouracil (5-FU) on hepatocellular carcinoma. The combination treatment significantly reduced migration, invasion, and angiogenesis, while also modulating apoptosis, autophagy, and NF-kappa B and Wnt pathway-related proteins. In vivo experiments showed that the combined treatment prolonged survival in a mouse model of hepatocellular carcinoma compared to either treatment alone.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Hamed Mirzaei, Jack McClelland, Devansh Sharma, Mohammad Arjmand, Mohammad H. H. Zarifi
Summary: This study focuses on investigating the real-time resonant microwave behavior of two polydimethylsiloxane (PDMS) structures in interaction with tetrahydrofuran (THF) and acetone, which are primary swelling agents. The interaction of the PDMS structures with target gases alters their structure, resulting in changes in the dielectric properties of the PDMS/gas system. Microwave resonators show substantial potential as versatile tools for investigating the physical changes in polymers during their interaction with gases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Editorial Material
Clinical Neurology
Auob Rustamzadeh, Daryoush Afshari, Hamid Reza Alizadeh-Otaghvar, Reza Ahadi, Amir Raoofi, Ronak Shabani, Armin Ariaei, Fatemeh Moradi
Summary: Horner syndrome is a neurological or/and neurosurgical disorder characterized by common signs including miosis, ptosis, anhidrosis, and enophthalmos. Enophthalmos can result from various factors, including carotid artery damage and neurocristopathy. Research has found that superior cervical ganglion sympathectomy can cause dysfunction of the lower eyelid components, leading to forward displacement of the lower eyelid and manifestation of enophthalmos symptoms.
CURRENT JOURNAL OF NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Elham Seidkhani, Fatemeh Moradi, Auob Rustamzadeh, Sara Simorgh, Sakine Shirvalilou, Mehdi Mehdizadeh, Hamed Dehghani, Zeinab Akbarnejad, Manijeh Motevalian, Enam Alhagh Charkhat Gorgich
Summary: This study aimed to evaluate the effects of sunitinib on GBM-bearing rats and compare the effects of different delivery methods on angiogenesis inhibition and hepatotoxicity. The results showed that intra-nasal delivery of sunitinib may be a potential non-hepatotoxic alternative for the treatment of GBM.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Dermatology
Hamidreza Alizadeh Otaghvar, Rafat Rezapour-Nasrabad, Mohammad Ali Ebrahimzadeh, Mehran Yaghoubi, Ali Reza Khalatbary, Davood Nasiry, Amir Raoofi, Auob Rostamzadeh
Summary: This study evaluated the anti-inflammatory and wound-healing potential of Feijoa sellowiana fruit extract in experimental rat models using stereological and molecular methods. The results showed that the extract had superior healing and anti-inflammatory effects.
JOURNAL OF WOUND CARE
(2022)