Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake

Metabonomics revealed xanthine oxidase-induced oxidative stress and inflammation in the pathogenesis of diabetic nephropathy

(2015) Jingping Liu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Functional analysis of novel allelic variants in URAT1 and GLUT9 causing renal hypouricemia type 1 and 2

(2015) Andrea Mancikova et al.   Clinical and Experimental Nephrology

Serum uric acid and the risk of cardiovascular and renal disease

(2015) Claudio Borghi et al.   JOURNAL OF HYPERTENSION

Uric acid promotes chemokine and adhesion molecule production in vascular endothelium via nuclear factor-kappa B signaling

(2015) W.Y. Liang et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 expression through inhibition of MAPK, Akt, and NF-κB signaling in human lung epithelial cells

(2015) Wen-Chung Huang et al.   Food & Function

Hyperuricemia, Gout, and Cardiovascular Disease: An Update

(2015) Aryeh M. Abeles   Current Rheumatology Reports

NF-κB signaling at the crossroads of inflammation and atherogenesis: searching for new therapeutic links

(2014) Ioannis Pateras et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis

(2014) You-Jin Choi et al.   FASEB JOURNAL

Uric Acid Promotes Apoptosis in Human Proximal Tubule Cells by Oxidative Stress and the Activation of NADPH Oxidase NOX 4

(2014) Daniela Verzola et al.   PLoS One

Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

(2013) Yongneng Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

1H NMR-based metabonomic analysis of serum and urine in a nonhuman primate model of diabetic nephropathy

(2013) Jingping Liu et al.   Molecular BioSystems

Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages

(2012) Wei-Tien Chang et al.   FOOD CHEMISTRY

Interaction between uric acid and endothelial dysfunction predicts new onset of diabetes in hypertensive patients

(2012) Francesco Perticone et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Uric acid transport and disease

(2010) Alexander So et al.   JOURNAL OF CLINICAL INVESTIGATION

A ‘complexity’ of urate transporters

(2010) Alan F. Wright et al.   KIDNEY INTERNATIONAL

Mutations in Glucose Transporter 9 Gene SLC2A9 Cause Renal Hypouricemia

(2008) Hirotaka Matsuo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

(2008) Veronique Vitart et al.   NATURE GENETICS

SLC2A9 Is a High-Capacity Urate Transporter in Humans

(2008) Mark J Caulfield et al.   PLOS MEDICINE