Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation

Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes

(2017) Mito Kuroda et al.   JOURNAL OF CELL SCIENCE

Mechanoaccumulative Elements of the Mammalian Actin Cytoskeleton

(2016) Eric S. Schiffhauer et al.   CURRENT BIOLOGY

Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma

(2016) Carolin Ploeger et al.   HEPATOLOGY

Vinculin head–tail interaction defines multiple early mechanisms for cell substrate rigidity sensing

(2016) Zengzhen Liu et al.   Integrative Biology

High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation

(2016) Andrew W. Holle et al.   Integrative Biology

Conformational plasticity of JRAB/MICAL-L2 provides “law and order” in collective cell migration

(2016) Ayuko Sakane et al.   MOLECULAR BIOLOGY OF THE CELL

SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug

(2016) Lele Song et al.   Oncotarget

Molecular-Scale Tools for Studying Mechanotransduction

(2015) Andrew S. LaCroix et al.   Annual Review of Biomedical Engineering

Microchidia protein 2, MORC2, downregulates the cytoskeleton adapter protein, ArgBP2, via histone methylation in gastric cancer cells

(2015) Yuxin Tong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission

(2015) V. Auernheimer et al.   JOURNAL OF CELL SCIENCE

Sorbs1 and 2 interact with Crk-L and are required for Acetylcholine receptor cluster formation

(2015) Peter T. Hallock et al.   MOLECULAR AND CELLULAR BIOLOGY

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Alpha-actinin binding kinetics modulate cellular dynamics and force generation

(2015) Allen J. Ehrlicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arg Kinase-binding Protein 2 (ArgBP2) Interaction with α-Actinin and Actin Stress Fibers Inhibits Cell Migration

(2014) Praju Vikas Anekal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the interaction of the vinculin proline-rich linker region with vinexin   in sensing the stiffness of the extracellular matrix

(2014) H. Yamashita et al.   JOURNAL OF CELL SCIENCE

Vinexin-β protects against cardiac hypertrophy by blocking the Akt-dependent signalling pathway

(2013) Ke Chen et al.   BASIC RESEARCH IN CARDIOLOGY

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

(2013) Alex Carisey et al.   CURRENT BIOLOGY

Cbl-associated protein regulates assembly and function of two tension-sensing structures in Drosophila

(2013) R. Bharadwaj et al.   DEVELOPMENT

PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7

(2013) Maud Martin et al.   EMBO JOURNAL

Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

(2013) Ingo Thievessen et al.   JOURNAL OF CELL BIOLOGY

How vinculin regulates force transmission

(2013) D. W. Dumbauld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ mechanotransduction via vinculin regulates stem cell differentiation

(2013) Andrew W. Holle et al.   STEM CELLS

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

Actomyosin-generated tension controls the molecular kinetics of focal adhesions

(2011) H. Wolfenson et al.   JOURNAL OF CELL SCIENCE

Dynamic and structural signatures of lamellar actomyosin force generation

(2011) Yvonne Aratyn-Schaus et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo

(2010) Noriyuki Kioka et al.   EXPERIMENTAL CELL RESEARCH

WAVE2 Forms a Complex with PKA and Is Involved in PKA Enhancement of Membrane Protrusions

(2010) Hiroshi Yamashita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

ArgBP2-Dependent Signaling Regulates Pancreatic Cell Migration, Adhesion, and Tumorigenicity

(2008) D. Taieb et al.   CANCER RESEARCH