Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

(2016) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

(2016) Ludivine Baron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon

(2015) T. Junne et al.   JOURNAL OF CELL SCIENCE

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Inhibitors of Protein Translocation Across the ER Membrane

(2015) Kai-Uwe Kalies et al.   TRAFFIC

Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

(2015) Joy Ogbechi et al.   PLoS Pathogens

Pleiotropic molecular effects of theMycobacterium ulceransvirulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer

(2014) Belinda Hall et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

(2014) Andrew L MacKinnon et al.   eLife

The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages

(2013) Nicholas Johnson et al.   PLoS One

A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function

(2012) Steven F. Trueman et al.   JOURNAL OF CELL BIOLOGY

TRC40 can deliver short secretory proteins to the Sec61 translocon

(2012) N. Johnson et al.   JOURNAL OF CELL SCIENCE

Orientation of Internal Signal-Anchor Sequences at the Sec61 Translocon

(2012) Lucyna Kocik et al.   JOURNAL OF MOLECULAR BIOLOGY

Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon Complex

(2011) Prasanna K. Devaraneni et al.   CELL

Secretory Protein Profiling Reveals TNF-α Inactivation by Selective and Promiscuous Sec61 Modulators

(2011) Sarah V. Maifeld et al.   CHEMISTRY & BIOLOGY

Buruli Ulcer: Advances in Understanding Mycobacterium ulcerans Infection

(2010) Douglas S. Walsh et al.   DERMATOLOGIC CLINICS

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

(2009) B. C. S. Cross et al.   JOURNAL OF CELL SCIENCE

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

(2009) S. Boulkroun et al.   JOURNAL OF IMMUNOLOGY

Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism

(2009) R. E. Simmonds et al.   JOURNAL OF IMMUNOLOGY

Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer

(2009) Manuel T Silva et al.   LANCET INFECTIOUS DISEASES

Delivering proteins for export from the cytosol

(2009) Benedict C. S. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sequence-specific Retention and Regulated Integration of a Nascent Membrane Protein by the Endoplasmic Reticulum Sec61 Translocon

(2008) David Pitonzo et al.   MOLECULAR BIOLOGY OF THE CELL