Aurora A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma

Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

(2016) Chun Shi et al.   JOURNAL OF CELL SCIENCE

Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells

(2015) Shu-Feng Zhou et al.   Drug Design Development and Therapy

Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma

(2015) Maria Inés Molejon et al.   Oncotarget

Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells

(2015) Rajendra P. Gajula et al.   NEOPLASIA

Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy

(2014) Tatsuzo Mizukami et al.   BMC CANCER

Systems Biology Approaches to Pancreatic Cancer Detection, Prevention and Treatment

(2014) Osama Alian et al.   CURRENT PHARMACEUTICAL DESIGN

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells

(2013) A B D'Assoro et al.   ONCOGENE

Emerging targets in pancreatic cancer: epithelial–mesenchymal transition and cancer stem cells

(2013) Nagaraj Nagathihalli et al.   OncoTargets and Therapy

LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy

(2012) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

(2012) K.-H. Chang et al.   JOURNAL OF CELL SCIENCE

Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes

(2012) Gongda Xue et al.   Cancer Discovery

Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters

(2011) Junlin Li et al.   BMC CANCER

Snail2 is an Essential Mediator of Twist1-Induced Epithelial Mesenchymal Transition and Metastasis

(2011) E. Casas et al.   CANCER RESEARCH

Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness

(2011) J. Hong et al.   CANCER RESEARCH

Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

(2011) Qian Qin et al.   CELL RESEARCH

The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1

(2011) Rachel Lander et al.   JOURNAL OF CELL BIOLOGY

PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer

(2011) E. O. Johnson et al.   JOURNAL OF CELL SCIENCE

Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

(2011) Kuei-Hua Chang et al.   MOLECULAR BIOLOGY OF THE CELL

IL-6 Stabilizes Twist and Enhances Tumor Cell Motility in Head and Neck Cancer Cells through Activation of Casein Kinase 2

(2011) Ying-Wen Su et al.   PLoS One

The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis

(2010) Junjiang Fu et al.   CELL RESEARCH

SNAIL induces epithelial-to-mesenchymal transition in a human pancreatic cancer cell line (BxPC3) and promotes distant metastasis and invasiveness in vivo

(2010) Ryohei Nishioka et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion

(2010) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redundant or separate entities?--roles of Twist1 and Twist2 as molecular switches during gene transcription

(2010) H. L. Franco et al.   NUCLEIC ACIDS RESEARCH

PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage

(2010) A Vichalkovski et al.   ONCOGENE

Direct and Indirect Roles of Cyclin-dependent Kinase 5 as an Upstream Regulator in the c-Jun NH2-Terminal Kinase Cascade: Relevance to Neurotoxic Insults in Alzheimer's Disease

(2009) Kai-Hui Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphoregulation of Twist1 Provides a Mechanism of Cell Fate Control

(2008) Anthony Firulli et al.   CURRENT MEDICINAL CHEMISTRY

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

(2008) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease

(2008) Kai-Hui Sun et al.   MOLECULAR BIOLOGY OF THE CELL