The Rap1-cofilin pathway coordinates actin reorganization and MTOC polarization at the B-cell immune synapse

Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion

(2016) Shubhankar Nath et al.   JOURNAL OF IMMUNOLOGY

Phosphomimic S3D Cofilin Binds Actin Filaments but does not Sever them

(2015) W. Austin Elam et al.   BIOPHYSICAL JOURNAL

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse

(2015) Anne Reversat et al.   MOLECULAR BIOLOGY OF THE CELL

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

(2015) Spencer A. Freeman et al.   Nature Communications

B Cells use Conserved Polarity Cues to Regulate Their Antigen Processing and Presentation Functions

(2015) Maria-Isabel Yuseff et al.   Frontiers in Immunology

The role of the cytoskeleton at the immunological synapse

(2014) Alex T. Ritter et al.   IMMUNOLOGICAL REVIEWS

The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation

(2013) Wenxia Song et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Antigen Binding and Activation

(2013) Balthasar A. Heesters et al.   IMMUNITY

Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage

(2013) Jason Yi et al.   JOURNAL OF CELL BIOLOGY

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

(2012) Kensaku Mizuno   CELLULAR SIGNALLING

Spectraplakins: Master orchestrators of cytoskeletal dynamics

(2012) Kathleen C. Suozzi et al.   JOURNAL OF CELL BIOLOGY

The Cytoskeletal Adaptor Protein IQGAP1 Regulates TCR-Mediated Signaling and Filamentous Actin Dynamics

(2012) J. A. Gorman et al.   JOURNAL OF IMMUNOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond

(2012) Morgan Huse   Frontiers in Immunology

IQGAP1 and its binding proteins control diverse biological functions

(2011) Colin D. White et al.   CELLULAR SIGNALLING

IQGAP1 involvement in MTOC and granule polarization in NK-cell cytotoxicity

(2011) Namita Kanwar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B Cell Receptor-Mediated Antigen Gathering Requires Ubiquitin Ligase Cbl and Adaptors Grb2 and Dok-3 to Recruit Dynein to the Signaling Microcluster

(2011) Tim Schnyder et al.   IMMUNITY

Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation

(2011) Akiko Hashimoto-Tane et al.   IMMUNITY

Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation

(2011) Maria-Isabel Yuseff et al.   IMMUNITY

Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity

(2011) Bebhinn Treanor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cofilin-Mediated F-Actin Severing Is Regulated by the Rap GTPase and Controls the Cytoskeletal Dynamics That Drive Lymphocyte Spreading and BCR Microcluster Formation

(2011) S. A. Freeman et al.   JOURNAL OF IMMUNOLOGY

Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

(2011) Gregory D. Rak et al.   PLOS BIOLOGY

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

(2010) Bebhinn Treanor et al.   IMMUNITY

Visualizing a role for the actin cytoskeleton in the regulation of B-cell activation

(2010) Facundo D. Batista et al.   IMMUNOLOGICAL REVIEWS

Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes

(2010) Aradhana Awasthi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of the Ancestral Polarity Regulator Protein Kinase C  at the Immunological Synapse Drives Polarization of Th Cell Secretory Machinery toward APCs

(2010) F. Bertrand et al.   JOURNAL OF IMMUNOLOGY

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation

(2010) Atsushi Nakano et al.   NATURE CELL BIOLOGY

B cell follicles and antigen encounters of the third kind

(2010) Jason G Cyster   NATURE IMMUNOLOGY

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cytoskeleton Coordinates the Early Events of B-cell Activation

(2010) N. E. Harwood et al.   Cold Spring Harbor Perspectives in Biology

Understanding the Structure and Function of the Immunological Synapse

(2010) M. L. Dustin et al.   Cold Spring Harbor Perspectives in Biology

Microsignalosomes: spatially resolved receptor signalling

(2009) Bebhinn Treanor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The molecular assembly and organization of signaling active B-cell receptor oligomers

(2009) Pavel Tolar et al.   IMMUNOLOGICAL REVIEWS

Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

(2009) Emily J Quann et al.   NATURE IMMUNOLOGY

The Rap GTPases Regulate B Cell Morphology, Immune-Synapse Formation, and Signaling by Particulate B Cell Receptor Ligands

(2008) Kevin B.L. Lin et al.   IMMUNITY

MTOC translocation modulates IS formation and controls sustained T cell signaling

(2008) Noa B. Martín-Cófreces et al.   JOURNAL OF CELL BIOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY