Article
Biochemistry & Molecular Biology
Zhiming Li, Xinzong Zhang, Shiming Xie, Xingping Liu, Caifeng Fei, Xunbin Huang, Yunge Tang, Li-quan Zhou
Summary: This study reveals the important role of Nuclear receptor binding SET domain protein 2 (Nsd2) in spermatogenesis. The loss of Nsd2 leads to apoptosis and abnormal development of spermatogenic cells, as well as dysregulation of genes and histone modifications. Furthermore, Nsd2 deficiency results in the retention of histones and increased protamine proteins in spermatozoa. These findings uncover the involvement of Nsd2 in chromatin remodeling during spermatogenesis and provide insights into the molecular mechanisms of epigenetic abnormalities affecting male reproductive health.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biology
Michael Borg, Ranjith K. Papareddy, Rodolphe Dombey, Elin Axelsson, Michael D. Nodine, David Twell, Frederic Berger
Summary: The alternation between morphologically distinct haploid and diploid life forms in plants and algae is controlled by epigenetic modifications such as the loss of H3K9me2 and global loss of H3K27me3. These events lead to significant changes in chromatin accessibility and transcriptional reprogramming, guiding the transition between generations in flowering plants.
Review
Immunology
Zachary Van Roy, Tammy Kielian
Summary: Epigenetics focuses on adaptable transcriptional regulation, influencing cell identity and function. During CNS infection, epigenetic mechanisms play a significant role in controlling immune cell maturation and antimicrobial properties. Researchers use epigenetic marks to organize immune cell populations' activation states and inflammatory processes in response to CNS infection.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Hiroto S. Fukushima, Hiroyuki Takeda, Ryohei Nakamura
Summary: Epigenetic modifications undergo erasure and reestablishment after fertilization, with some histone modifications escaping reprogramming. In nonmammalian vertebrates, most histone modifications are thought to be intensively erased and reestablished. However, the histone modifications that escape reprogramming in nonmammalian vertebrates and their potential functional roles remain unknown.
Article
Oncology
Sakshi Goel, Vipul Bhatia, Tanay Biswas, Bushra Ateeq
Summary: The epigenetic landscape plays a crucial role in cell fate, differentiation, and prostate cancer progression, and research suggests its significance in the epigenetic reprogramming in cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Agricultural Engineering
Zishuo Zhang, Yan Ao, Ning Su, Yuxin Chen, Kexin Wang, Lijin Ou
Summary: The study investigates the dynamic changes in morphological traits, oil content, fatty acid composition, and other components during the seed development of X. sorbifolium. The optimal harvest time for edible oil production is 70-75 DAA, while for biodiesel production, it is 60 DAA.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Oncology
Rajnish Kumar Singh, Dipayan Bose, Erle S. Robertson
Summary: Epigenetic reprogramming of the KSHV genome occurs during hypoxia, leading to enrichment of both transcriptional activator and repressor modifications of histones. KSHV-encoded antigens contribute to the increase in modified histone proteins. Specific regions of the KSHV genome are critical for DNA replication under hypoxic conditions.
Article
Biochemistry & Molecular Biology
Amber M. Helliwell, Peter A. Stockwell, Christina D. Edgar, Aniruddha Chatterjee, Warren P. Tate
Summary: This study maps the genomic changes in ME/CFS patients during relapse recovery cycles and finds functionally important changes in their DNA methylomes that are associated with metabolic, immune, and inflammatory dysfunctions. These findings provide potential practical applications for strategies to decrease relapse frequency in ME/CFS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Peng Chen, Youxuan Li, Yangmei Zhang, Chunyu Xue, Philip K. Hopke, Xinghua Li
Summary: Residential biomass combustion in developing countries produces significant primary particulate matter emissions. This study investigated the dynamic changes of emitted PM chemical composition from a typical improved stove burning wood and crop straw in China. The results showed higher emissions of pollutants, including organic aerosol and polycyclic aromatic hydrocarbons, during the flaming stage of combustion. The study also explored the role of PAHs as intermediate products in the conversion of organic aerosol to black carbon.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Immunology
Mohsen Keshavarz, Ailar Sabbagh, Khadijeh Koushki, Seyed Mohammad Miri, Behrang Sarshari, Katayoun Vahdat, Amir Ghaemi
Summary: This paper reviews how influenza viruses manipulate cellular gene activity through epigenetic mechanisms to control their life cycles, providing insights into the complex functional interactions between viral and cellular factors for therapeutic intervention and vaccine development against influenza infections. Copyright © 2021 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
MICROBES AND INFECTION
(2021)
Article
Oncology
Isabel Gomez-Redondo, Benjamin Planells, Sebastian Canovas, Elena Ivanova, Gavin Kelsey, Alfonso Gutierrez-Adan
Summary: The study found that methylation reprogramming in pig germ cells follows the general dynamics shown in mice and humans, unveiling genomic elements that behave differently between male and female germ cells.
CLINICAL EPIGENETICS
(2021)
Article
Medicine, Research & Experimental
Shen Li, Feiyang Ma, Tomohiro Yokota, Gustavo Garcia, Amelia Palermo, Yijie Wang, Colin Farrell, Yu-Chen Wang, Rimao Wu, Zhiqiang Zhou, Calvin Pan, Marco Morselli, Michael A. Teitell, Sergey Ryazantsev, Gregory A. Fishbein, Johanna ten Hoeve, Valerie A. Arboleda, Joshua Bloom, Barbara Dillon, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Vaithilingaraja Arumugaswami, Arjun Deb
Summary: The authors successfully reproduced the systemic toxicity and multiorgan involvement induced by SARS-CoV-2 in a mouse model through viral delivery, revealing that metabolic and epigenetic changes could contribute to the pathogenesis of COVID-19.
Review
Plant Sciences
Lauriane Simon, Aline V. Probst
Summary: Controlled transcription of genes is crucial for cell differentiation and development. This process involves multiple layers of regulation, including nucleosome composition, chromatin folding, and chromatin interactions in the nucleus. Recent technological advances have provided insight into these mechanisms and dynamic changes during stress response and development.
Review
Oncology
Daniel J. Simpson, Nelly N. Olova, Tamir Chandra
Summary: Ageing is inevitable, but recent research has shown that slowing down and reversing the ageing process may be possible through induced pluripotent stem cells and epigenetic rejuvenation. Reprogramming-induced rejuvenation strategies offer promising candidates for safely reducing biological age.
CLINICAL EPIGENETICS
(2021)
Article
Chemistry, Multidisciplinary
Lirui Wang, Chunlei Zhang, Yuping Hong, Xinhong Li, Tangan Li, Ang Gao, Shaojun Pan, Bin Liu, Han Jin, Daxiang Cui
Summary: The study developed a method of combinatorial delivery of epigenetic modulatory drugs through self-assembly, effectively regulating DNA methylation and histone deacetylation, ultimately inhibiting tumor cell proliferation and promoting cell apoptosis.
Article
Genetics & Heredity
Silvana Rosic, Rachel Amouroux, Cristina E. Requena, Ana Gomes, Max Emperle, Toni Beltran, Jayant K. Rane, Sarah Linnett, Murray E. Selkirk, Philipp H. Schiffer, Allison J. Bancroft, Richard K. Grencis, Albert Jeltsch, Petra Hajkova, Peter Sarkies
Correction
Genetics & Heredity
Harry G. Leitch, Petra Hajkova
Editorial Material
Genetics & Heredity
Harry G. Leitch, Petra Hajkova
Article
Multidisciplinary Sciences
Peter W. S. Hill, Harry G. Leitch, Cristina E. Requena, Zhiyi Sun, Rachel Amouroux, Monica Roman-Trufero, Malgorzata Borkowska, Jolyon Terragni, Romualdas Vaisvila, Sarah Linnett, Hakan Bagci, Gopuraja Dharmalingham, Vanja Haberle, Boris Lenhard, Yu Zheng, Sriharsa Pradhan, Petra Hajkova
Article
Biochemistry & Molecular Biology
Nevena Cvetesic, Harry G. Leitch, Malgorzata Borkowska, Ferenc Mueller, Piero Carninci, Petra Hajkova, Boris Lenhard
Article
Multidisciplinary Sciences
Daphne A. C. Stapels, Peter W. S. Hill, Alexander J. Westermann, Robert A. Fisher, Teresa L. Thurston, Antoine-Emmanuel Saliba, Isabelle Blommestein, Joerg Vogel, Sophie Helaine
Article
Genetics & Heredity
Sarah Wyck, Carolina Herrera, Cristina E. Requena, Lilli Bittner, Petra Hajkova, Heinrich Bollwein, Raffaella Santoro
EPIGENETICS & CHROMATIN
(2018)
Article
Cell Biology
Alejandro Carrillo-Jimenez, Ozgen Deniz, Maria Victoria Niklison-Chirou, Rocio Ruiz, Karina Bezerra-Salomao, Vassilis Stratoulias, Rachel Amouroux, Ping Kei Yip, Anna Vilalta, Mathilde Cheray, Alexander Michael Scott-Egerton, Eloy Rivas, Khadija Tayara, Irene Garcia-Dominguez, Juan Garcia-Revilla, Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Xianli Shen, Peter St George-Hyslop, Guy Charles Brown, Petra Hajkova, Bertrand Joseph, Jose Luis Venero, Miguel Ramos Branco, Miguel Angel Burguillos
Article
Cell Biology
Qifan Zhu, Fei Sang, Sarah Withey, Walfred Tang, Sabine Dietmann, Doris Klisch, Priscila Ramos-Ibeas, Haixin Zhang, Cristina E. Requena, Petra Hajkova, Matt Loose, M. Azim Surani, Ramiro Alberio
Summary: Research on pig primordial germ cells has shown large-scale epigenomic reprogramming during early embryonic development, including DNA demethylation, repair, and re-expression of certain genes. Additionally, some gene regions in hypomethylated PGCs exhibit resistance to demethylation, suggesting potential for transgenerational epigenetic inheritance.
Article
Microbiology
Peter W. S. Hill, Ana Laura Moldoveanu, Molly Sargen, Severin Ronneau, Izabela Glegola-Madejska, Catrin Beetham, Robert A. Fisher, Sophie Helaine
Summary: Tolerance and persistence are superficially similar survival mechanisms for bacteria under antibiotic pressure, but they are underpinned by different physiological processes. Multidrug-tolerant bacteria enter a near-dormant state to avoid immune-mediated genotoxic damage, while persisters remain active to withstand macrophage-induced DNA breaks.
CELL HOST & MICROBE
(2021)
Review
Microbiology
Severin Ronneau, Peter W. S. Hill, Sophie Helaine
Summary: Antibiotic tolerance and persistence are two phenomena that are superficially similar but have different physiological mechanisms, and need to be distinguished in experimental studies. While antibiotic tolerance arises from genetic mutations or environmental conditions causing growth restriction in bacteria, antibiotic persistence is a challenging transient phenomenon.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tien-Chi Huang, Yi-Fang Wang, Eric Vazquez-Ferrer, Ina Theofel, Cristina E. Requena, Courtney W. Hanna, Gavin Kelsey, Petra Hajkova
Summary: The stability of the epigenetic landscape is crucial for maintaining cell-type-specific transcription profiles. DNA methylation is important for long-term gene silencing, while Polycomb plays a central role in transcriptional control in the context of a developmental reprogramming system.
Article
Cell Biology
Kathleen R. Stewart-Morgan, Cristina E. Requena, Valentin Flury, Qian Du, Zoe Heckhausen, Petra Hajkova, Anja Groth
Summary: The researchers developed a mass spectrometry-based method called iDEMS to measure DNA modifications on metabolically labeled DNA. This method revealed a hemi-methylated landscape on nascent DNA and showed that methylation maintenance is slower than cell division in mouse embryonic stem cells. They also found that hydroxymethylation is asymmetric between sister strands, favoring the parental strand.
NATURE CELL BIOLOGY
(2023)
Review
Multidisciplinary Sciences
Chongyuan Luo, Petra Hajkova, Joseph R. Ecker
