Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature

Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells

(2017) Kem A. Sochacki et al.   NATURE CELL BIOLOGY

Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission

(2017) Johannes Schöneberg et al.   Nature Communications

Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes

(2016) Clothilde Cauvin et al.   CURRENT BIOLOGY

Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells

(2016) Nawal Bendris et al.   JOURNAL OF CELL SCIENCE

OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates

(2016) Peter G. Billcliff et al.   MOLECULAR BIOLOGY OF THE CELL

The oculocerebrorenal syndrome of Lowe: an update

(2016) Arend Bökenkamp et al.   PEDIATRIC NEPHROLOGY

CRISPR-Cas9D10A nickase-based genotypic and phenotypic screening to enhance genome editing

(2016) Ting-Wei Will Chiang et al.   Scientific Reports

Specification of Architecture and Function of Actin Structures by Actin Nucleation Factors

(2015) Colleen T. Skau et al.   Annual Review of Biophysics

An Engineered Minimal WASP-Myosin Fusion Protein Reveals Essential Functions for Endocytosis

(2015) Eric B. Lewellyn et al.   DEVELOPMENTAL CELL

Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics

(2015) D. Li et al.   SCIENCE

Visualizing the functional architecture of the endocytic machinery

(2015) Andrea Picco et al.   eLife

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Actin and dynamin2 dynamics and interplay during clathrin-mediated endocytosis

(2014) Alexandre Grassart et al.   JOURNAL OF CELL BIOLOGY

Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

(2014) Benoit Pasquier et al.   JOURNAL OF MEDICINAL CHEMISTRY

A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

(2014) Ramiro Nández et al.   eLife

Advances in Analysis of Low Signal-to-Noise Images Link Dynamin and AP2 to the Functions of an Endocytic Checkpoint

(2013) François Aguet et al.   DEVELOPMENTAL CELL

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

(2013) York Posor et al.   NATURE

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Development of PI3K inhibitors: lessons learned from early clinical trials

(2013) Jordi Rodon et al.   Nature Reviews Clinical Oncology

Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9

(2013) J. L. Gallop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles for Actin Assembly in Endocytosis

(2012) Olivia L. Mooren et al.   Annual Review of Biochemistry

Building Distinct Actin Filament Networks in a Common Cytoplasm

(2011) Alphée Michelot et al.   CURRENT BIOLOGY

Synaptojanin 1-Mediated PI(4,5)P2 Hydrolysis Is Modulated by Membrane Curvature and Facilitates Membrane Fission

(2011) Belle Chang-Ileto et al.   DEVELOPMENTAL CELL

OCRL controls trafficking through early endosomes via PtdIns4,5P2-dependent regulation of endosomal actin

(2011) Mariella Vicinanza et al.   EMBO JOURNAL

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

(2011) Steeve Boulant et al.   NATURE CELL BIOLOGY

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

(2011) Marcus J. Taylor et al.   PLOS BIOLOGY

Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides

(2010) Juha Saarikangas et al.   PHYSIOLOGICAL REVIEWS

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

Coordinated Actions of Actin and BAR Proteins Upstream of Dynamin at Endocytic Clathrin-Coated Pits

(2009) Shawn Ferguson et al.   DEVELOPMENTAL CELL

Differential requirements for actin during yeast and mammalian endocytosis

(2009) Soheil Aghamohammadzadeh et al.   NATURE CELL BIOLOGY

EFC/F-BAR proteins and the N-WASP–WIP complex induce membrane curvature-dependent actin polymerization

(2008) Kazunari Takano et al.   EMBO JOURNAL

SNX9 - a prelude to vesicle release

(2008) R. Lundmark et al.   JOURNAL OF CELL SCIENCE

SNX9 Activities are Regulated by Multiple Phosphoinositides Through both PX and BAR Domains

(2007) Defne Yarar et al.   TRAFFIC