期刊
JOURNAL OF CELL BIOLOGY
卷 216, 期 10, 页码 2995-2997出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201709034
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- NIGMS NIH HHS [R01 GM066251] Funding Source: Medline
Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https ://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosome maturation, viability, and dendrite growth of neurons in vivo.
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