期刊
DALTON TRANSACTIONS
卷 44, 期 47, 页码 20523-20531出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5dt03037d
关键词
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资金
- University of Camerino (Fondo di Ateneo per la Ricerca)
- MIUR [2010BNZ3F2]
- COST (European Network on Smart Inorganic Polymers) [CM 1302]
A series of half-sandwich cyclopentadienyl rhodium(III) and iridium(III) complexes of the type [Cp*M(curc/bdcurc) Cl] and [Cp*M(curc/bdcurc)(PTA)][SO3CF3], in which Cp* = pentamethylcyclopentadienyl, curcH = curcumin and bdcurcH = bisdemethoxycurcumin as O boolean AND O-chelating ligands, and PTA = 1,3,5-triaza-7-phosphaadamantane, is described. The X-ray crystal structures of three of the complexes, i.e. [Cp*Rh( curc)(PTA)][SO3CF3] (5), [Cp*Rh(bdcurc)(PTA)][SO3CF3] (6) and [Cp*Ir(bdcurc)(PTA)][SO3CF3] (8), confirm the expected piano-stool geometry. With the exception of 5, the complexes are stable under pseudophysiological conditions and are moderately cytotoxic to human ovarian carcinoma (A2780 and A2780cisR) cells and also to non-tumorigenic human embryonic kidney (HEK293) cells, but lack the cancer cell selectivity observed for related arene ruthenium(II) complexes.
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