Review
Immunology
Jiayi Yin, Shiming Zhang, Chao Yang, Yan Wang, Bing Shi, Qian Zheng, Ni Zeng, Hanyao Huang
Summary: Mechanical forces play a significant role in scar formation and skin regeneration, understanding these mechanisms is crucial for the development of effective scar therapies. This review provides an overview of the current understanding of mechanotransduction signaling pathways and strategies for reducing mechanical forces in the injured area.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Polymer Science
Doaa Alshora, Lubna Ashri, Rihaf Alfaraj, Ahlam Alhusaini, Raeesa Mohammad, Nawal Alanaze, Mohamed Ibrahim, Mohamed Badran, Mounir Bekhit, Shaikha Alsaif, Modhi Alagili, Rehab Ali, Adel Jreebi
Summary: This study aims to formulate a biofilm composed of silver sulfadiazine, chitosan, and sodium alginate, and evaluate its effectiveness in wound healing. The optimized formulation showed reasonable mechanical properties and significantly higher antibacterial activity compared to the blank biofilm. In vivo study demonstrated a 75% reduction in wound width with the formulated biofilm.
Article
Pharmacology & Pharmacy
Ruby Singh, Purandhi Roopmani, Meenakshi Chauhan, Suparna Mercy Basu, Waghela Deeksha, M. D. Kazem, Sarbani Hazra, Eerappa Rajakumara, Jyotsnendu Giri
Summary: In this study, dressing materials with dual properties of anti-bacterial and regenerative were developed for complex and large asymmetric burns. The results demonstrated sustained release of silver sulfadiazine (SSD) and concentration-dependent antibacterial activity. The airbrushed nanofibers showed biocompatibility, supported the differentiation and regeneration of cells, and facilitated complete recovery of burn wounds in rabbit models. The core-shell nanofibers displayed anti-inflammatory and proliferative activity without adverse tissue response.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Cell Biology
Manjula P. Mony, Kelly A. Harmon, Ryan Hess, Amir H. Dorafshar, Sasha H. Shafikhani
Summary: This review article provides an overview of hypertrophic scarring (HTS), which is an aberrant form of wound healing characterized by excessive deposition of extracellular matrix and connective tissue at the injury site. The article discusses the normal wound healing phases and the dysregulated mechanisms associated with HTS development. It also reviews animal models of HTS, their limitations, and the current and emerging treatments for HTS.
Review
Biochemistry & Molecular Biology
Matus Coma, Lucia Frohlichova, Lukas Urban, Robert Zajicek, Tomas Urban, Pavol Szabo, Stepan Novak, Vitaly Fetissov, Barbora Dvorankova, Karel Smetana, Peter Gal
Summary: This review highlights the molecular features of fibroblasts and their interactions with immune and epithelial cells, as well as extracellular matrix, shedding light on the complexity of connective tissue accumulation and hypertrophic scarring. The comparison of different types of fibroblasts and their roles in skin repair and regeneration post-burn injury provides insights into the underlying mechanisms of tissue healing. Overall, the study presents a comprehensive overview of the molecular changes associated with hypertrophic scarring following burns, encompassing all stages of wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Xiaoya Liu, Haiyang Fan, Zhiyun Meng, Zhuona Wu, Ruolan Gu, Xiaoxia Zhu, Hui Gan, Guifang Dou
Summary: This study investigated the combination of nano-sized silver sulfadiazine loaded in poloxamer thermosensitive hydrogel (NS/Gel) for burn wound treatment. The results showed that NS/Gel significantly accelerated wound healing and eradicated Staphylococcus aureus infection, making it a promising approach for clinical burn wound treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Dermatology
Andrzej Hecker, Marlies Schellnegger, Elisabeth Hofmann, Hanna Luze, Sebastian Philipp Nischwitz, Lars-Peter Kamolz, Petra Kotzbeck
Summary: Resveratrol is a powerful antioxidant that may aid in wound healing and prevent skin aging. Current research suggests that resveratrol could be a feasible treatment approach, but further studies are needed to confirm its effects.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Instruments & Instrumentation
Majid Salehi, Arian Ehterami, Saeed Farzamfar, Ahmad Vaez, Somayeh Ebrahimi-Barough
Summary: The alginate/naringenin hydrogel developed in this study showed positive effects on wound healing process, with appropriate porosity and biodegradability, as well as no toxicity to cells. In the rat experiment, the hydrogel containing 20% naringenin demonstrated the best wound closure among other groups.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Hendrik Lintel, Darren B. Abbas, Christopher Lavin, Michelle Griffin, Jason L. Guo, Nicholas Guardino, Andrew Churukian, Geoffrey C. Gurtner, Arash Momeni, Michael T. Longaker, Derrick C. Wan
Summary: Deferoxamine treatment has shown to improve wound healing outcomes in chronically irradiated murine skin. It accelerates wound closure, enhances wound perfusion, upregulates angiogenesis, and improves scar elasticity. Deferoxamine also increases inducible nitric oxide synthase expression and nitric oxide production in early healing wounds.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Cell Biology
Hongbo Chen, Kai Hou, Yiping Wu, Zeming Liu
Summary: Hypertrophic scars or keloid formation is a complex process involving multiple cells and factors. Adipose stem cells (ASCs) have shown potential in treating hypertrophic scarring or keloid, making them a promising approach for treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dermatology
Yizhao Ma, Zhifang Liu, LinLin Miao, Xinyu Jiang, Hongyu Ruan, Rongrong Xuan, Suling Xu
Summary: Pathological scarring is caused by excessive proliferation and transdifferentiation of fibroblasts, as well as excessive deposition of extracellular matrix during wound healing. Factors that promote pathological scar formation affect the proliferation and function of fibroblasts. This study explores the microenvironment, signaling pathways, epigenetics, and autophagy related to the abnormal formation of fibroblasts in pathological scarring. Understanding the causes of abnormal fibroblast formation may lead to improved prevention and treatment strategies for pathological scarring and enhance patients' quality of life.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Chemistry, Analytical
Carlo Bergonzi, Annalisa Bianchera, Giulia Remaggi, Maria Cristina Ossiprandi, Ruggero Bettini, Lisa Elviri
Summary: The growing demand for personalized medicine requires innovative drug manufacturing using 3D printing technology to produce hydrogels for controlled drug delivery. This study explored the use of chitosan/alginate-based hydrogels loaded with silver sulfadiazine for wound healing. Different 3D chitosan/alginate architectures were designed to modulate drug release, and significant differences were observed in terms of elasticity, water content, and antimicrobial potency.
Article
Polymer Science
Nafise Amiri, Sahand Ghaffari, Ida Hassanpour, Taesik Chae, Reza Jalili, Ruhangiz Taghi Kilani, Frank Ko, Aziz Ghahary, Dirk Lange
Summary: A silver nanoparticle-based hydrogel composite has been created to prevent infection, promote tissue repair, and fill cavities in wounds that are difficult to reach with other dressings.
Article
Engineering, Biomedical
Sang Oon Baek, Uk Jang, Jeonghwan Shin, Jun Hyeok Kim, Jie Hyun Kim, Jun Yong Lee
Summary: The authors introduce a novel animal wound model using an internal splint made of nitinol, a shape memory alloy, to effectively impede wound contraction while not affecting the re-epithelialization rate, successfully mimicking the human wound healing mechanism. This model is robust, reliable, and easily reproducible.
BIOMEDICAL MATERIALS
(2021)
Article
Dermatology
Yi-Kai Hong, Yi-Han Chang, Yu-Chen Lin, Brandon Chen, Bryan Edgar K. Guevara, Chao-Kai Hsu
Summary: This review provides a summary of the current knowledge on the immunopathogenesis and treatment options for pathological scars. Pathological scars, such as hypertrophic scars and keloids, result from abnormal inflammation during wound healing and have negative impacts on patients' quality of life due to their disfiguring appearance and symptoms of itch and pain.
ADVANCES IN WOUND CARE
(2023)