Review
Polymer Science
Md Mahamudul Hasan Rumon, Anwarul Azim Akib, Fahmida Sultana, Md Moniruzzaman, Mahruba Sultana Niloy, Md Salman Shakil, Chanchal Kumar Roy
Summary: Self-healing hydrogels are promising materials in biomedical applications with controllable responses to external stimuli. The suitable combination of materials and challenges in development are crucial for their advancement.
Review
Polymer Science
Anupama Devi V. K, Rohin Shyam, Arunkumar Palaniappan, Amit Kumar Jaiswal, Tae-Hwan Oh, Arputharaj Joseph Nathanael
Summary: The review highlights the importance of smart self-healing hydrogels, their self-healing mechanisms, evaluation methods, and applications. It also discusses the use of composite materials to enhance mechanical properties, as well as methods for evaluating self-healing properties and recent advancements in 3D bioprinting. Finally, it presents current challenges and future perspectives in the field.
Article
Chemistry, Applied
Pritiranjan Mondal, Kaushik Chatterjee
Summary: The researchers developed a polysaccharide-based double network hydrogel with excellent thixotropic and self-healing properties, as well as high compressive fracture strength. Encapsulated cells remained viable within the hydrogel and released drugs effectively killed cancer cells or inhibited bacterial growth. This work demonstrates the potential of using the hydrogel as a minimally-invasive platform for drug and cell delivery.
CARBOHYDRATE POLYMERS
(2022)
Review
Materials Science, Biomaterials
Nazneen Pathan, Pravin Shende
Summary: Smart polymeric materials and hydrogels derived from acrylate, epoxy resins, etc. mimic the healing ability of natural organisms and biological cells by showing shape memory and tissue regenerative properties, and have a wide range of applications in biomedical field with better biocompatibility, healing efficiency and higher tensile strength.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Shun Yao, Junjie Chi, Yuetong Wang, Yuanjin Zhao, Yuan Luo, Yongan Wang
Summary: A degradable zinc-MOF encapsulated microneedles array was fabricated in this study, showing excellent antibacterial activity and biocompatibility, which can accelerate wound healing and tissue regeneration.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Yingshu Guo, Shiwei Liu, Dan Jing, Nianzu Liu, Xiliang Luo
Summary: Elastin-like polypeptides (ELPs) are thermally responsive biopolymers with unique properties that can be tailored through genetic engineering. They have been widely used in drug delivery and tissue repair applications due to their biocompatibility, prolonged drug release, and nanostructure formation capabilities.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Shang Lyu, Zhifei Dong, Xiaoxiao Xu, Ho-Pan Bei, Ho-Yin Yuen, Chung-Wai James Cheung, Man-Sang Wong, Yong He, Xin Zhao
Summary: Microneedles have gained widespread attention as a novel drug delivery system due to their non-invasiveness, painless administration, controllable drug delivery, and versatile cargo loading capacity. In addition to transdermal drug delivery, microneedles have shown promising results in promoting wound healing and tissue regeneration. This review provides an overview of microneedle systems, including potential cargos, structural designs, material selection, and drug release mechanisms. It also summarizes different fabrication methods and the recent progress of microneedle-assisted wound healing and tissue regeneration in various tissues and organs.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tiantian Wu, Hong Wang, Run Tian, Shuang Guo, Yuhui Liao, Jianbing Liu, Baoquan Ding
Summary: In this study, a DNA origami-based bactericide was developed for efficient treatment of infected wounds by organizing DNAzymes and broad-spectrum antibiotics, promoting healing process.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Multidisciplinary
Jingyuan Ji, Chengjin Wang, Zhuo Xiong, Yuan Pang, Wei Sun
Summary: Bone repair is a complex process that involves angiogenesis and osteogenesis, controlled by various factors. This study proposes a 3D-printed scaffold with a sequential delivery platform to promote the coupling regeneration of blood vessels and bones. The scaffold showed enhanced proliferation and differentiation of BMSCs and HUVECs in vitro, and better angiogenesis and osteoinductive effects in vivo.
MATERIALS TODAY ADVANCES
(2022)
Article
Polymer Science
Seongpil An, Sam S. Yoon, Min Wook Lee
Summary: This article discusses cutting-edge self-healing technologies for hard materials and their expected healing processes, as well as summarizes the progress made in novel self-healing fiber-reinforced plastic composites, concrete, and metal materials. The focus is on research at the frontier of self-healing structural materials.
Article
Chemistry, Multidisciplinary
Li Wang, Lingyu Sun, Feika Bian, Yu Wang, Yuanjin Zhao
Summary: Self-bonded hydrogel particles, achieved through photothermal conversion and phase change, offer a solution for wound healing and drug delivery monitoring.
Review
Materials Science, Multidisciplinary
Srivatsan Ramesh, Saad Khan, Yaewon Park, Ericka Ford, Stefano Menegatti, Jan Genzer
Summary: This comprehensive review discusses textile hybrids or composites capable of self-healing and repairing fabrics against damages across different size scales. The review covers the chemistry and fabrication principles, stimuli-driven and autonomous healing, and methods to characterize the recovery of various properties. The article also explores the limitless uses of next-generation self-healing systems.
Review
Polymer Science
Siyu Pan, Chongyu Zhu, Yuwei Wu, Lei Tao
Summary: Chitosan-based self-healing hydrogels, prepared via dynamic imine bonds, are promising smart soft materials in biomedical fields. This review provides a comprehensive overview of their design, fabrication, and biomedical applications in tissue regeneration, drug delivery, biosensors, and 3D/4D printing. Challenges and future perspectives for the development of chitosan-based self-healing hydrogels in the biomedical field are also discussed.
Article
Polymer Science
Zijia Wang, Xinyue Zhai, Ming Fan, Huaping Tan, Yong Chen
Summary: In this study, magnetic microspheres based on chitosan derivatives were developed and a thermal-reversible, self-healing hydrogel was prepared by incorporating these microspheres. The hybrid scaffolds synthesized with the magnetic microspheres showed controllable shape and mobility under magnetic force. The scaffolds exhibited good morphology, dispersity, and stability in physical environment.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Shih-Ho Lin, Abel Po-Hao Huang, Shan-hui Hsu
Summary: Stroke is a global disease with high mortality, and the regeneration of neural tissue during intracerebral hemorrhage stroke is limited by various factors. To overcome this limitation, a chitosan micellar self-healing hydrogel is developed as an injectable implant for brain tissue regeneration. The hydrogel has similar properties to the brain, including shape adaptability and proper swelling. It can release two different drugs with asynchronous kinetics, providing targeted treatment for different phases of the stroke. In animal models, the hydrogel shows promising results in terms of behavioral improvement, balanced brain midline shift, and evidence of neurogenesis and angiogenesis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Yuan Li, Zhiming Wang, Xiuwen Wu, Gefei Wang, Guosheng Gu, Huajian Ren, Zhiwu Hong, Jianan Ren
Summary: This study comprehensively evaluated the genome-wide DNA methylation changes in intestinal mucosa tissue of adult patients with Crohn's disease. Abnormal DNA methylation sites were identified and correlated with genes related to apoptosis, IL-8 production, and inflammatory pathways. The degree of abnormal methylation of MUC1 was negatively correlated with the disease activity of Crohn's disease, suggesting a potential role in disease progression.
SCIENTIFIC REPORTS
(2021)
Letter
Critical Care Medicine
Sicheng Li, Xiuwen Wu, Jianan Ren
CRITICAL CARE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ye Liu, Jinjian Huang, Ziyan Xu, Sicheng Li, Yungang Jiang, Gui Wen Qu, Zongan Li, Yun Zhao, Xiuwen Wu, Jianan Ren
Summary: Polyacrylamide/gelatin/silver nanoparticle (PAAm-GelatinAgNPs) ink was designed to improve gelatin-based hydrogels by enhancing their mechanical properties and providing antibacterial capabilities. The ink's shear thinning property enabled the printing of complex 3D scaffolds for potential applications in customized therapy for antimicrobial and anti-UV damage to tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Immunology
Wenbin Gong, Peizhao Liu, Tao Zheng, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: Syk, a cytoplasmic non-receptor protein tyrosine kinase, plays crucial roles in signal transduction in various cells, especially in gut diseases. Inhibitors targeting Syk show great potential for the treatment of gut diseases.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Guopu Chen, Yunru Yu, Xiao Fu, Gefei Wang, Zhiming Wang, Xiuwen Wu, Jianan Ren, Yuanjin Zhao
Summary: Metal organic frameworks (MOFs) are proposed as attractive materials for their adjustable structures and physicochemical properties, with a focus on developing functional materials with catalytic capabilities for biomedical values. Biocompatible manganese metal organic framework (Mn-MOF)-based catalase mimetics with microfluidic microcapsule encapsulation were presented for intravital inflammatory bowel disease (IBD) treatment. These Mn-MOF-encapsulated microcapsules showed high performance in treating spontaneous IBD in interleukin-10-deficient mice by relieving oxidative stress and reducing inflammation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Biomedical
Cheng Zhao, Guopu Chen, Huan Wang, Yuanjin Zhao, Renjie Chai
Summary: A novel microcapsule inspired by scavenger behavior is introduced for cleaning intestinal LPS, protecting cells, and reducing inflammation. It has been demonstrated to be a promising candidate for treating metabolic syndrome and other LPS related diseases.
BIOACTIVE MATERIALS
(2021)
Correction
Materials Science, Biomaterials
Qinqing Tang, Canwen Chen, Yungang Jiang, Jinjian Huang, Ye Liu, Peter M. Nthumba, Guosheng Gu, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: Correction for the paper "Engineering an adhesive based on photosensitive polymer hydrogels and silver nanoparticles for wound healing" by Qinqing Tang et al., published in J. Mater. Chem. B, 2020, 8, 5756-5764, DOI: 10.1039/d0tb00726a.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Immunology
Yangguang Li, Wenbin Gong, Weizhen Li, Peizhao Liu, Juanhan Liu, Haiyang Jiang, Tao Zheng, Jie Wu, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: This article reviews the activation factors of the IRG1-Itaconate axis and its role in regulating the inflammatory pathway in macrophages. It also summarizes the relationship between the axis and the metabolism of macrophages. Furthermore, it highlights the connections between the IRG1-Itaconate axis and inflammatory diseases.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zi-Yan Xu, Jin-Jian Huang, Ye Liu, Can-Wen Chen, Gui-Wen Qu, Ge-Fei Wang, Yun Zhao, Xiu-Wen Wu, Jian-An Ren
Summary: This study proposes a novel bioink based on decellularized extracellular matrix (dECM) for organoid bioprinting. Intestinal organoids cultured in this bioink exhibit robust generation and distinct characteristics. The development of this bioink has the potential to advance the application of organoids in translational medicine and disease modeling.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Jie Wu, Qinjie Liu, Xufei Zhang, Miaomiao Tan, Xuanheng Li, Peizhao Liu, Lei Wu, Fan Jiao, Zhaoyu Lin, Xiuwen Wu, Xin Wang, Yun Zhao, Jianan Ren
Summary: The mechanism by which STING causes lethal sepsis through inducing macrophage ferroptosis in an interferon-independent manner is explored. The interaction between STING and NCOA4 is found to be critical in this process. The selective 20-HETE synthase inhibitor, HET0016, is shown to reduce STING-induced ferroptosis and mortality in septic mice. These findings provide insights into sepsis and potential therapeutic targets.
CELL DEATH & DISEASE
(2022)
Article
Engineering, Biomedical
Guiwen Qu, Jinjian Huang, Ze Li, Yungang Jiang, Ye Liu, Kang Chen, Ziyan Xu, Yun Zhao, Guosheng Gu, Xiuwen Wu, Jianan Ren
Summary: This study presents a multi-responsive, flexible, and biocompatible 4D-printed bilayer hydrogel that can mimic the curved morphology of intestines. The hydrogel can undergo deformation by immersing in sodium lactate and exposing to UV light, and the bending degree can be programmed by modifying the pre-stretched lengths. Additionally, the hydrogel demonstrates effective closure for enteroatmospheric fistulas.
MATERIALS TODAY BIO
(2022)
Article
Materials Science, Multidisciplinary
Jinjian Huang, Jie Wu, Jiahang Wang, Mengjia Xu, Jiao Jiao, Yuhao Qiang, Feng Zhang, Zongan Li
Summary: This study introduced a novel electrohydrodynamic cyroprinting method to create micropatterned fiber scaffolds with increased porosity and roughness. The rough surface of the scaffolds enhanced the adhesion of adipose-derived MSCs, leading to improved wound healing through enhanced paracrine action and reduced inflammation.
ADVANCED FIBER MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Guopu Chen, Jie Hu, Zhiwu Hong, Gefei Wang, Zhiming Wang, Canwen Chen, Jinjian Huang, Xiuwen Wu, Jianan Ren
Summary: Novel multifunctional electrospun textiles containing kaolinite and silver nanoparticles were fabricated to promote wound healing. The textiles exhibited therapeutic effects in terms of accelerating wound healing process.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wenbin Gong, Kun Guo, Tao Zheng, Haohao Xie, Weijie Li, Mengxuan Li, Zhiwu Hong, Huajian Ren, Guosheng Gu, Gefei Wang, Xiuwen Wu, Jianan Ren
Summary: The JINLING score was found to be significantly correlated with FCP, CRP, and hemoglobin. In the validation cohort, patients with high inflammation grade (JINLING >= 4) had higher GHAS, CRP, and FCP than low inflammation grade patients. High JINLING score was associated with an increased risk of treatment failure.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Chemistry, Applied
Yukai Chen, Yu Wang, Jiaojiao Fang, Baoying Dai, Jiahui Kou, Chunhua Lu, Yuanjin Zhao
Summary: By constructing AB-PVDF inverse opal photonic crystal and introducing a microreactor, combined with slow light and photothermal effects, the photocatalytic efficiency was significantly enhanced. The enhanced photothermal catalysis by photonic crystal-microreactor has great potential for alleviating the deteriorating water environment.
CHINESE JOURNAL OF CATALYSIS
(2021)
