Article
Chemistry, Multidisciplinary
Yangnan Hu, Zhuoyue Chen, Hongyang Wang, Jiahui Guo, Jiaying Cai, Xiaoyan Chen, Hao Wei, Jieyu Qi, Qiuju Wang, Huisheng Liu, Yuanjin Zhao, Renjie Chai
Summary: Inspired by the structures of peripheral nerves, researchers have developed a conductive topological scaffold for nerve repair using modified butterfly wings. The scaffold showed increased neurite length and guided cellular orientation, and successfully repaired nerve defects in rats.
Review
Biotechnology & Applied Microbiology
Ane Escobar, Rui Luis Reis, Joaquim Miguel Oliveira
Summary: Peripheral nerve injuries are a common cause of disabilities, and treatment with long nerve gap autografts is currently considered the best method. However, due to limited availability and potential issues at the donor site, research is focusing on developing regenerative strategies using artificial nerve guidance conduits (NGCs). These NGCs can be optimized through various methods to enhance nerve regeneration, and recent advancements in using different types of nanoparticles to introduce growth factors to NGCs are discussed in depth.
Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Faranak Mankavi, Rana Ibrahim, Hongjun Wang
Summary: This article summarizes the recent advances in nerve guidance conduits (NGCs) for peripheral nerve regeneration and repair, including biomaterial innovations, structural design, advanced fabrication technologies, and cellular responses to biomimetic cues.
Article
Engineering, Biomedical
Qingqing Lu, Feng Zhang, Weinan Cheng, Xiang Gao, Zhaozhao Ding, Xiaoyi Zhang, Qiang Lu, David L. Kaplan
Summary: The study utilized modular assembly for fabricating nerve conduits with multifunctional guidance cues, which promoted cell proliferation and growth factor secretion, and demonstrated improved nerve regeneration in both cell and animal experiments for rat sciatic nerve defects.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Shang Wu, Wen Shen, Xuemei Ge, Fen Ao, Yan Zheng, Yigang Wang, Xiaoni Jia, Yueyang Mao, Yali Luo
Summary: Peripheral nerve injury is a common complication, and the traditional autologous nerve graft approach is limited. Nerve guidance conduits are widely used as an alternative, but they currently cannot meet the needs of large gap nerve injuries. Functional nerve conduits that incorporate electrical or magnetic stimulation and Schwann cells show promise for bridging large gap nerve injuries. Additionally, functional nerve conduits provide a new method for constructing drug and growth factor delivery systems in vivo.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Xing Yu, Deteng Zhang, Chang Liu, Zhaodi Liu, Yujun Li, Qunzi Zhao, Changyou Gao, Yong Wang
Summary: The grafting of KHI peptides onto a porous and micropatterned PLCL film, loaded with NGF, significantly improved Schwann cell adhesion, ratio of length/width, and elongation percentage in vitro. In vivo, electromyography and nerve morphological changes after severe traction injury were significantly improved in the MPLCL-peptide group and MPLCL-peptide-NGF group compared to the PLCL group.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Teng Wan, Yi-Lin Wang, Feng-Shi Zhang, Xiao-Meng Zhang, Yi-Chong Zhang, Hao-Ran Jiang, Meng Zhang, Pei-Xun Zhang
Summary: This review discusses the importance of porous structures in peripheral nerve guidance conduits (NGCs) and their impact on physical properties and cellular behavior during peripheral nerve regeneration. It provides an overview of the features and classification of porous structures in NGCs, as well as common methods for constructing them. The review also emphasizes the significance of ideal porous structures in the regeneration of peripheral nerve tissue engineering materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Afsoon Farzan, Sedigheh Borandeh, Jukka Seppala
Summary: This study successfully synthesized biodegradable, conductive, solvent-free polyurethane/PEGylated graphene oxide (PU/PEG-GO) composites and 3D printed them into flexible nerve conduits with different geometries using stereolithography. The composite containing 5% PEG-GO showed the highest mechanical properties and conductivity, as well as good biocompatibility and biodegradability, making it a potential candidate for peripheral nerve regeneration.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Ane Escobar, Aleksandra Serafin, Mariana R. Carvalho, Mario Culebras, Andres Cantarero, Anne Beaucamp, Rui L. Reis, J. Miguel Oliveira, Maurice N. Collins
Summary: Novel PEDOT nanoparticles combined with silk fibroin are promising biomaterials for peripheral nerve regeneration, showing excellent mechanical and conductivity properties and avoiding scar tissue formation.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Derya Burcu Hazer Rosberg, Baki Hazer, Lena Stenberg, Lars B. Dahlin
Summary: The study showed that conduits modified with gold and cobalt-oxide nanoparticles improved axonal outgrowth and decreased the number of apoptotic Schwann cells, leading to enhanced nerve regeneration after reconstruction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Simon C. Kellaway, Victoria Roberton, Joshua N. Jones, Rabea Loczenski, James B. Phillips, Lisa J. White
Summary: Incorporating dECMh derived from bone, liver, and small intestinal tissues can promote neurite extension and axonal regeneration, providing an alternative to current collagen I hydrogel.
ACTA BIOMATERIALIA
(2023)
Article
Immunology
Sepehr Aghajanian, Aliasghar Taghi Doulabi, Masoume Akhbari, Alireza Shams
Summary: The study assessed the efficacy of NH2-GO and Fr in a rat facial nerve motor neuron axotomy model using a ST conduit. Results showed an increase in regenerating axons and mean axon diameter with NH2-GO and a decrease in myelin surface area with Fr. Joint application of NH2-GO and Fr led to more regenerated axons and increased myelin thickness compared to the hydrogel group.
INFLAMMATION AND REGENERATION
(2021)
Review
Chemistry, Multidisciplinary
Kai Liu, Lesan Yan, Ruotao Li, Zhiming Song, Jianxun Ding, Bin Liu, Xuesi Chen
Summary: Nerve autograft is currently the preferred treatment for peripheral nerve defects but has limitations. Emerging nerve guide conduits (NGCs), especially those made through 3D printing, offer effective platforms for repairing peripheral nerve defects.
Article
Biochemistry & Molecular Biology
Poornima Ramburrun, Pradeep Kumar, Elias Ndobe, Yahya E. Choonara
Summary: This study evaluated a biosimulated nerve repair system providing three types of regenerative cues in a peripheral nerve injury model. The nanofibers supported PC12 proliferation, preserved muscle mass, and gradually improved functional recovery. The combination of physical guidance, chemical cues, and therapeutic cues offers a promising strategy for the regeneration of severed peripheral nerves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Dena Shahriari, Jacob Y. Koffler, Mark H. Tuszynski, Wendy M. Campana, Jeff S. Sakamoto
TISSUE ENGINEERING PART A
(2017)
Article
Biochemistry & Molecular Biology
Jacob Koffler, Wei Zhu, Xin Qu, Oleksandr Platoshyn, Jennifer N. Dulin, John Brock, Lori Graham, Paul Lu, Jeff Sakamoto, Martin Marsala, Shaochen Chen, Mark H. Tuszynski
Review
Materials Science, Biomaterials
Kayla J. Wolf, Sanjay Kumar
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Chemistry, Multidisciplinary
Dena Shahriari, Gabriel Loke, Ian Tafel, Seongjun Park, Po-Han Chiang, Yoel Fink, Polina Anikeeva
ADVANCED MATERIALS
(2019)
Review
Nanoscience & Nanotechnology
Kayla J. Wolf, Joseph Chen, Jason D. Coombes, Manish K. Aghi, Sanjay Kumar
NATURE REVIEWS MATERIALS
(2019)
Article
Oncology
Joseph Chen, Badriprasad Ananthanarayanan, Kelsey S. Springer, Kayla J. Wolf, Sharon M. Sheyman, Vivien D. Tran, Sanjay Kumar
Article
Multidisciplinary Sciences
Kayla J. Wolf, Poojan Shukla, Kelsey Springer, Stacey Lee, Jason D. Coombes, Caleb J. Choy, Samuel J. Kenny, Ke Xu, Sanjay Kumar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Chemistry, Multidisciplinary
Yoonhee Jin, Dena Shahriari, Eun Je Jeon, Seongjun Park, Yi Sun Choi, Jonghyeok Back, Hyungsuk Lee, Polina Anikeeva, Seung-Woo Cho
Summary: The passage highlights the need for interventions to induce functional skeletal muscle restoration, with a focus on tissue-engineered muscle constructs. It mentions the current challenges in reliable cell sources and tissue scaffold engineering for tissue-engineering treatments.
ADVANCED MATERIALS
(2021)
Article
Materials Science, Biomaterials
Ruoxing Lei, Erin A. Akins, Kelly C. Y. Wong, Nicole A. Repina, Kayla J. Wolf, Garrett E. Dempsey, David Schaffer, Andreas Stahl, Sanjay Kumar
Summary: Biophysical cues in the extracellular matrix regulate cell behavior in a complex, nonlinear, and interdependent manner. A high-throughput HA platform has been developed for parallel culture and analysis of cells in various matrix conditions. This platform allows individual treatment and analysis of each matrix environment, providing valuable insights into mechanotransduction.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Engineering, Biomedical
Aleksandra Serafin, Mario Culebras Rubio, Marta Carsi, Pilar Ortiz-Serna, Maria J. Sanchis, Atul K. Garg, J. Miguel Oliveira, Jacob Koffler, Maurice N. Collins
Summary: The incorporation of PEDOT NPs into Gel:HA biomaterial scaffolds enhances the conductive capabilities and provides a healing environment for stimulating regeneration in spinal cord injuries.
BIOMATERIALS RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Aleksandra Serafin, Mario Culebras, J. Miguel Oliveira, Jacob Koffler, Maurice N. N. Collins
Summary: Electrically conductive Gel:HA:PPy-NP scaffolds were synthesized by combining polypyrrole nanoparticles (PPy NP) with a gelatin/hyaluronic acid (HA) hydrogel. These scaffolds have excellent mechanical properties and conductive capabilities, making them a promising option for tissue engineering in nervous tissue regeneration.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Review
Neurosciences
Dena Shahriari, Dekel Rosenfeld, Polina Anikeeva
Article
Engineering, Biomedical
Kayla J. Wolf, Stacey Lee, Sanjay Kumar
APL BIOENGINEERING
(2018)
Article
Engineering, Biomedical
K. M. Pawelec, J. Koffler, D. Shahriari, A. Galvan, M. H. Tuszynski, J. Sakamoto
BIOMEDICAL MATERIALS
(2018)