期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 32, 期 1, 页码 54-65出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328217712110
关键词
Graphene oxide; hyaluronic acid; RGD peptide; dual-receptor; synergic effect; targeting drug delivery system; cancer therapeutic
资金
- National Natural Science Foundation of China [51473130, 51572206]
- National Students' Innovation and Entrepreneurship Training Program of Wuhan University and Technology [20161049720008, 20161049720009, 20161049720012]
Graphene oxide (GO) modified with hyaluronic acid (HA) and Arg-gly-asp peptide (RGD) was designed as a dual-receptor targeting drug delivery system to enhance the specificity and efficiency of anticancer drug delivery. Firstly, GO-HA-RGD conjugate was characterized to reveal its structure and morphology. Whereafter, doxorubicin (Dox) as a model drug was loaded on GO-HA-RGD carrier, which displayed a high loading rate (72.9%, GO:Dox (w/w)=1:1), pH-response and sustained drug release behavior. Cytotoxicity experiments showed that GO-HA-RGD possessed excellent biocompatibility towards SKOV-3 and HOSEpiC cells. Additionally, the GO-HA-RGD/Dox had a stronger cytotoxicity for SKOV-3 cells than either GO-HA/Dox (single receptor) or GO/Dox (no receptor). Moreover, celluar uptake studies illustrated that GO-HA-RGD conjugate could be effectively taken up by SKOV-3 cells via a synergic effect of CD44-HA and integrin-RGD mediated endocytosis. Hence, GO-HA-RGD nanocarrier is able to be a promising platform for targeted cancer therapeutic.
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