Exogenous neutrophil elastase enters bronchial epithelial cells and suppresses cigarette smoke extract–induced heme oxygenase-1 by cleaving sirtuin 1

Neutrophil Elastase Differentially Regulates Interleukin 8 (IL-8) and Vascular Endothelial Growth Factor (VEGF) Production by Cigarette Smoke Extract

(2015) Kyoung-Hee Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

(2014) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)

(2013) Koichiro Mihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence

(2012) Hongwei Yao et al.   BIOCHEMICAL PHARMACOLOGY

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Heme Oxygenase-1 in Lung Disease

(2012) Chintan M. Raval et al.   CURRENT DRUG TARGETS

Clathrin Pit-mediated Endocytosis of Neutrophil Elastase and Cathepsin G by Cancer Cells

(2012) Alyssa D. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

(2011) Nicolas Mercado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts

(2011) Xiaoxia Zhu et al.   PLoS One

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease

(2011) Irfan Rahman et al.   PREVENTIVE MEDICINE

NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease

(2011) A. Boutten et al.   TRENDS IN MOLECULAR MEDICINE

Pathogenic triad in COPD: oxidative stress, protease–antiprotease imbalance, and inflammation

(2011) Bernard Fischer et al.   International Journal of Chronic Obstructive Pulmonary Disease

Oxidative stress targets in pulmonary emphysema: focus on the Nrf2 pathway

(2010) A Boutten et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Leukocyte Elastase Induces Lung Epithelial Apoptosis via a PAR-1–, NF-κB–, and p53-Dependent Pathway

(2009) Tomoko Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Heme Oxygenase-1 Prevents Airway Mucus Hypersecretion Induced by Cigarette Smoke in Rodents and Humans

(2008) Abdelhamid Almolki et al.   AMERICAN JOURNAL OF PATHOLOGY

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE