Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

(2016) Lisha Zhou et al.   EMBO REPORTS

Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain

(2016) Aurelia Vergeade et al.   MITOCHONDRION

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

(2016) Sushabhan Sadhukhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon

(2016) Lulu Li et al.   Scientific Reports

Site-Specific Reactivity of Nonenzymatic Lysine Acetylation

(2015) Josue Baeza et al.   ACS Chemical Biology

Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome

(2015) J. Dudek et al.   EMBO Molecular Medicine

AlacZreporter gene expression atlas for 313 adult KOMP mutant mouse lines

(2015) David B. West et al.   GENOME RESEARCH

NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance

(2015) Feng Li et al.   MOLECULAR CELL

The Reactome pathway Knowledgebase

(2015) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

(2015) Jonathan R Friedman et al.   eLife

Membrane microenvironment regulation of carnitine palmitoyltranferases I and II

(2015) Khosrow Kashfi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase

(2015) Yuxun Zhang et al.   PLoS One

Cardiac Metabolic Pathways Affected in the Mouse Model of Barth Syndrome

(2015) Yan Huang et al.   PLoS One

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes

(2013) Eugenia Mileykovskaya et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site

(2013) Sivakama S. Bharathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

The stability and activity of respiratory Complex II is cardiolipin-dependent

(2012) Christine T. Schwall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline

(2012) Birgit Schilling et al.   MOLECULAR & CELLULAR PROTEOMICS

Direct Interaction of Mitochondrial Targeting Presequences with Purified Components of the TIM23 Protein Complex

(2011) Milit Marom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Characterization of the Recombinant Human Mitochondrial Trifunctional Protein

(2010) Benjamin Fould et al.   BIOCHEMISTRY

Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms

(2010) Nobuko Matsushita et al.   GENES TO CELLS

Evidence for Physical Association of Mitochondrial Fatty Acid Oxidation and Oxidative Phosphorylation Complexes

(2010) Yudong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY