Endoplasmic reticulum stress–induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis

Tetrameric Assembly of K + Channels Requires ER-Located Chaperone Proteins

(2017) Kai Li et al.   MOLECULAR CELL

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

Cell Biology: ERADicating Survival with BOK

(2016) Jerry Edward Chipuk et al.   CURRENT BIOLOGY

Is BOK required for apoptosis induced by endoplasmic reticulum stress?

(2016) Yuniel Fernandez-Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma

(2016) Amit J. Sabnis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Emerging tale of UPR and cancer: an essentiality for malignancy

(2016) Younis Mohammad Hazari et al.   TUMOR BIOLOGY

The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock

(2016) A C West et al.   Oncogenesis

gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum

(2015) Ting Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR

(2014) Scott A. Houck et al.   MOLECULAR CELL

Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

(2013) Yoshinari Miyata et al.   ACS Chemical Neuroscience

Smac mimetic compound LCL161 sensitizes esophageal carcinoma cells to radiotherapy by inhibiting the expression of inhibitor of apoptosis protein

(2013) Qin Qin et al.   TUMOR BIOLOGY

A Novel Mammalian ER-located J-protein, DNAJB14, Can Accelerate ERAD of Misfolded Membrane Proteins

(2012) Pattarawut Sopha et al.   CELL STRUCTURE AND FUNCTION

Hsp70 Protein Complexes as Drug Targets

(2012) Victoria A. Assimon et al.   CURRENT PHARMACEUTICAL DESIGN

Mechanisms for quality control of misfolded transmembrane proteins

(2011) Scott A. Houck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Huh-7 cell line as an alternative cultural model for the production of human like erythropoietin (EPO)

(2011) Humera Kausar et al.   Journal of Translational Medicine

Selective Abrogation of BiP/GRP78 Blunts Activation of NF- B through the ATF6 Branch of the UPR: Involvement of C/EBP  and mTOR-Dependent Dephosphorylation of Akt

(2011) S. Nakajima et al.   MOLECULAR AND CELLULAR BIOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

A Novel ER J-protein DNAJB12 Accelerates ER-associated Degradation of Membrane Proteins Including CFTR

(2010) Yo-hei Yamamoto et al.   CELL STRUCTURE AND FUNCTION

Modularity of the Hrd1 ERAD complex underlies its diverse client range

(2010) Kazue Kanehara et al.   JOURNAL OF CELL BIOLOGY

The endoplasmic reticulum–associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3–dependent degradation of nascent CFTRΔF508

(2010) Diane E. Grove et al.   MOLECULAR BIOLOGY OF THE CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Usa1 Functions as a Scaffold of the HRD-Ubiquitin Ligase

(2009) Sabine C. Horn et al.   MOLECULAR CELL

Dissecting the ER-Associated Degradation of a Misfolded Polytopic Membrane Protein

(2008) Kunio Nakatsukasa et al.   CELL

Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508

(2008) Daisuke Morito et al.   MOLECULAR BIOLOGY OF THE CELL

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY