Activation and mechanism of a cryptic oviedomycin gene cluster via the disruption of a global regulatory gene,adpA, inStreptomyces ansochromogenes

Biosynthesis and molecular regulation of secondary metabolites in microorganisms

(2017) Yue Li et al.   Science China-Life Sciences

Coordinative Modulation of Chlorothricin Biosynthesis by Binding of the Glycosylated Intermediates and End Product to a Responsive Regulator ChlF1

(2016) Yue Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection

(2015) Fang Guo et al.   METABOLIC ENGINEERING

Identified members of the Streptomyces lividans AdpA regulon involved in differentiation and secondary metabolism

(2014) Aurélie Guyet et al.   BMC MICROBIOLOGY

Genome Mining-Directed Activation of a Silent Angucycline Biosynthetic Gene Cluster inStreptomyces chattanoogensis

(2014) Zhenxing Zhou et al.   CHEMBIOCHEM

Genomics-Guided Discovery of Endophenazines from Kitasatospora sp. HKI 714

(2014) Daniel Heine et al.   JOURNAL OF NATURAL PRODUCTS

A γ-butyrolactone-sensing activator/repressor, JadR3, controls a regulatory mini-network for jadomycin biosynthesis

(2014) Zhengzhong Zou et al.   MOLECULAR MICROBIOLOGY

Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074

(2014) Carlos Olano et al.   Microbial Biotechnology

Improvement of gougerotin and nikkomycin production by engineering their biosynthetic gene clusters

(2013) Deyao Du et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Cryptic Polyene Biosynthetic Gene Cluster in Streptomyces calvus Is Expressed upon Complementation with a Functional bldA Gene

(2013) Lindsay Kalan et al.   CHEMISTRY & BIOLOGY

Molecular Regulation of Antibiotic Biosynthesis in Streptomyces

(2013) G. Liu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba

(2013) E. J. Sherwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly and features of secondary metabolite biosynthetic gene clusters in Streptomyces ansochromogenes

(2013) XingYu Zhong et al.   Science China-Life Sciences

Chitin-Induced Gene Expression in Secondary Metabolic Pathways of Streptomyces coelicolor A3(2) Grown in Soil

(2012) Behnam Nazari et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

β-Glucuronidase as a Sensitive and Versatile Reporter in Actinomycetes

(2011) Maksym Myronovskyi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes

(2011) Steven T Pullan et al.   BMC GENOMICS

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis

(2011) Madan K. Kharel et al.   NATURAL PRODUCT REPORTS

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“Pseudo” γ-Butyrolactone Receptors Respond to Antibiotic Signals to Coordinate Antibiotic Biosynthesis

(2010) Gangming Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SBSPKS: structure based sequence analysis of polyketide synthases

(2010) Swadha Anand et al.   NUCLEIC ACIDS RESEARCH

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters

(2009) T. Weber et al.   JOURNAL OF BIOTECHNOLOGY

The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis inStreptomyces ansochromogenes

(2009) Yuanyuan Pan et al.   MOLECULAR MICROBIOLOGY

Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA inStreptomyces griseus

(2009) Genki Akanuma et al.   MOLECULAR MICROBIOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator

(2009) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidation of Oxygenation Steps during Oviedomycin Biosynthesis and Generation of Derivatives with Increased Antitumor Activity

(2008) Felipe Lombó et al.   CHEMBIOCHEM

ClustScan : an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

(2008) Antonio Starcevic et al.   NUCLEIC ACIDS RESEARCH