Article
Multidisciplinary Sciences
Yusuke Hirata, Miki Takahashi, Yuto Yamada, Ryosuke Matsui, Aya Inoue, Ryo Ashida, Takuya Noguchi, Atsushi Matsuzawa
Summary: TFAs promote p53-dependent apoptosis through enhancing the Nox-RIP1-ASK1-MAPK pathway activation in response to CDDP ICLs, revealing diverse pathogenetic mechanisms of TFAs based on the types of DNA damage.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Ghada Ismail, Randa Abo El Naga, Maysaa El Sayed Zaki, Jana Jabbour, Ayoub Al-Jawaldeh
Summary: Around one third of products in the Egyptian market have a high TFA content, especially traditional meat products and fried foods with used oils.
Article
Chemistry, Applied
Tian Li, Qin Guo, Yang Qu, Hongzhi Liu, Li Liu, Yu Zhang, Qiang Wang
Summary: The inhibitory effect of trans-resveratrol (trans-Res) on the formation of trans fatty acids (TFAs) in peanut oil (PO) through thermal isomerization has been investigated. It was found that trans-Res effectively reduced the formation of TFAs by inhibiting the formation of C18:2 and C18:1 through proton transfer isomerism. The active reaction site of trans-Res preferentially interacted with the allyl groups in PO, leading to higher energy barriers and lower reaction rates, which resulted in the reduction of TFAs formation.
Article
Multidisciplinary Sciences
Xue Tian, Yu Gao, Mowei Kong, Lihua Zhao, Enhong Xing, Qitian Sun, Jianqiu He, Yanan Lu, Zengbin Feng
Summary: In this study, it was found that liraglutide could effectively reduce insulin resistance through regulating SESN2 expression and increasing autophagy activity. The findings suggest that liraglutide may be a potential therapeutic option for insulin resistance in diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Hong Wu, Xiaolei Xu, Ancheng Zheng, Weina Wang, Li Mei, Yue Chen, Shasha Sun, Liujun Jiang, Yutao Wu, Yijiang Zhou, Min Zheng, Qishan Chen
Summary: The study demonstrates that TIPE1 plays a protective role in hepatocytes by inhibiting specific signaling pathways to reduce hepatocyte steatosis, inflammation, and fibrosis during the NASH process, suggesting it as a potential therapeutic target for NAFLD.
Article
Nutrition & Dietetics
Farzad Mohammadi, Nicolas Bertrand, Iwona Rudkowska
Summary: The objective of this study is to evaluate the taste preference of trans fatty acids (TFA) and its effects on mice. The results showed that mice preferred consuming TFA, but their preference varied depending on the specific type of TFA. In conclusion, this study demonstrates the potential for TFA substitution in diet.
Article
Biotechnology & Applied Microbiology
Jing Chen, Yanan Song, Qiaozi Wang, Qiyu Li, Haipeng Tan, Jinfeng Gao, Ning Zhang, Xueyi Weng, Dili Sun, Wusiman Yakufu, Zhengmin Wang, Juying Qian, Zhiqing Pang, Zheyong Huang, Junbo Ge
Summary: Researchers have developed biomimetic nanoparticles for targeted and broad-spectrum anti-inflammation therapy of acute myocardial infarction (MI). These nanoparticles can neutralize proinflammatory cytokines and regulate the immune microenvironment, thereby suppressing inflammation and promoting angiogenesis in a mouse model of MI.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Caitlin C. Zebley, Hossam A. Abdelsamed, Hazem E. Ghoneim, Shanta Alli, Charmaine Brown, Dalia Haydar, Tian Mi, Tarsha Harris, Maureen A. McGargill, Giedre Krenciute, Ben Youngblood
Summary: The study found that IL-12 plays an important role in the priming of CD8 T cells, promoting TET2-mediated demethylation programming and influencing the expression of IFNg. This suggests that cytokines can guide the induction of epigenetically regulated traits in T cells.
Article
Nutrition & Dietetics
Weerapak Samsiripong, Sirinya Phulkerd, Umaporn Pattaravanich, Manasigan Kanchanachitra
Summary: This study aimed to analyze government policies and actions to eliminate TFAs in Thailand, and found that policy actors play different roles and have varying influences in the process. The study suggests that strengthening government actions in terms of enforcement and creating consumer awareness could further enhance the elimination of TFAs in Thailand.
Article
Pharmacology & Pharmacy
Mingming Fan, Huijuan Xiao, Dingyun Song, Lili Zhu, Jie Zhang, Xinran Zhang, Jing Wang, Huaping Dai, Chen Wang
Summary: AKEX0011, a novel N-arylpyridone compound, has been found to have protective effects against silicosis. It ameliorates lung damage and respiratory dysfunction caused by silica, reduces the secretion of inflammatory and fibrotic factors, inhibits cell apoptosis and signaling pathways, and regulates macrophage polarization.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Liping Huang, Adedayo E. E. Ojo, Judith Kimiywe, Alex Kibet, Boni M. M. Ale, Clementina E. E. Okoro, Jimmy Louie, Fraser Taylor, Mark D. D. Huffman, Dike B. B. Ojji, Jason H. Y. Wu, Matti Marklund
Summary: While the prevalence of industrially produced trans-fatty acids (iTFA) in African countries is largely unknown, this study investigated the presence of ingredients indicative of iTFAs in pre-packaged foods collected from Kenya and Nigeria. The findings revealed a low proportion of products containing specific ingredients suggestive of iTFAs, but a higher proportion containing non-specific ingredients. Additionally, the reporting of trans-fatty acid levels was generally low in both countries.
Article
Food Science & Technology
Christian Mayela Bousset-Alferes, Jorge Luis Chavez-Servin, Pedro Alberto Vazquez-Landaverde, Claudia Azucena Betancourt-Lopez, Maria del Carmen Caamano, Roberto Augusto Ferriz-Martinez, Elsa Fernanda Chavez-Alabat, Ma Guadalupe Lovaton-Cabrera, Karina de la Torre-Carbot
Summary: Breast milk may contain industrially produced trans fatty acids (TFAs), which can have significant implications for the development of infants. The content of TFAs in breast milk can be influenced by the mother's diet, and specific fatty acid concentrations are correlated with the composition of other fatty acids in breast milk.
FOOD SCIENCE & NUTRITION
(2022)
Article
Plant Sciences
Xue Han, Ye Wang, Peipei Zhang, Manli Zhu, Ling Li, Xinmin Mao, Xiaoting Sha, Linlin Li
Summary: Faecal microbiota transplantation (FMT) from Kazak individuals with normal glucose tolerance (KNGT) can improve glycolipid disorders in type 2 diabetes mellitus db/db mice by changing the bacterial composition responsible for producing short-chain fatty acids (SCFAs) and activating the G protein-coupled receptor 43 (GPR43)/glucagon-like peptide-1 (GLP-1) pathway.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xincheng Wu, Xiaojun Huang, Wanning Ma, Mingzhi Li, Jiajia Wen, Chunhua Chen, Liandi Liu, Shaoping Nie
Summary: This study compared the intestinal immunomodulatory mechanisms of nine representative bioactive polysaccharides. The results revealed that these polysaccharides promote intestinal immunity through different ways, such as alleviating immune suppression in intestinal mucosal T cells, improving the intestinal microenvironment, promoting the colonization of beneficial bacteria, inhibiting the colonization of harmful bacteria, and alleviating the accumulation of certain metabolites in the large intestine. These findings provide a guideline for the development of superior intestinal immunomodulatory polysaccharides.
Article
Gastroenterology & Hepatology
Shadi Salloum, Andre J. Jeyarajan, Annie J. Kruger, Jacinta A. Holmes, Tuo Shao, Mozhdeh Sojoodi, Myung-Ho Kim, Zhu Zhuo, Stuti G. Shroff, Andrew Kassa, Kathleen E. Corey, Sanjoy K. Khan, Wenyu Lin, Nadia Alatrakchi, Esperance A. K. Schaefer, Raymond T. Chung
Summary: This study reveals the significant role of YAP in NAFLD-associated liver fibrosis, with its activation potentially driven by FFA-induced p38 MAPK activation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tomohiro Kagi, Rio Naganuma, Aya Inoue, Takuya Noguchi, Shuhei Hamano, Yuto Sekiguchi, Gi-Wook Hwang, Yusuke Hirata, Atsushi Matsuzawa
Summary: Polymyxin B (PMB) is a potent antibiotic against multidrug-resistant bacteria, but its clinical use is limited due to serious side effects like nephrotoxicity and neurotoxicity. This study found that PMB induces necrosis and inflammatory cytokine release in macrophages, potentially contributing to organ toxicity. This provides novel insights into the mechanisms of PMB-related adverse effects.
JOURNAL OF ANTIBIOTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Akira Inaba, Hidemitsu Harada, Shojiro Ikezaki, Mika Kumakami-Sakano, Haruno Arai, Marii Azumane, Hayato Ohshima, Kazumasa Morikawa, Kuniyuki Kano, Junken Aoki, Keishi Otsu
Summary: This study investigated the impact of the LPA-LPA(6)-RhoA signaling axis on maturation stage ameloblasts. The results showed that LPA and LPA-producing enzymes were highly expressed in ameloblasts. In vitro experiments demonstrated the essential role of LPA-LPA(6)-RhoA signaling in establishing proper cell morphology and polarity, as well as regulating cell-cell junctions and actin cytoskeleton expression and stability.
JOURNAL OF ORAL BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yoko Hoshino, Toshiaki Okuno, Daisuke Saigusa, Kuniyuki Kano, Shota Yamamoto, Hideo Shindou, Junken Aoki, Kanji Uchida, Takehiko Yokomizo, Nobuko Ito
Summary: The study revealed the significant role of the LPA-LPA(1) signaling pathway in acute nociceptive pain, particularly in modulating neuronal sensitivity and pain behavior. The results indicate that LPA produced in innervated DRGs promotes the activation of SGCs, increasing neuronal sensitivity, and modulating pain behavior.
Review
Biochemistry & Molecular Biology
Qingyun Guo, Ichiro Kawahata, An Cheng, Wenbin Jia, Haoyang Wang, Kohji Fukunaga
Summary: Stroke is a leading cause of death and disability worldwide, but effective neuroprotective therapies for ischemic stroke patients are lacking. Lipids play important roles in the pathogenesis of neurological diseases, and fatty acid-binding proteins (FABPs) have been found to be involved in neurodegenerative diseases. However, FABPs' roles in ischemic stroke have received comparatively little attention. In this review, we summarize the literature on the associations between FABPs and ischemia and propose potential therapeutic targets for ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Takashi Toyama, Sidi Xu, Yoshitomi Kanemitsu, Takashi Hasegawa, Takuya Noguchi, Jin-Yong Lee, Atsushi Matsuzawa, Akira Naganuma, Gi-Wook Hwang
Summary: This study revealed a novel mechanism of methylmercury toxicity, in which methylmercury directly modifies Cys105 in OSM, thereby inhibiting cell proliferation via promoting binding to TNFR3.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yusuke Hirata, Ruiqi Cai, Allen Volchuk, Benjamin E. Steinberg, Yoshiro Saito, Atsushi Matsuzawa, Sergio Grinstein, Spencer A. Freeman
Summary: The oxidizing lipid peroxides formed during ferroptosis accumulate at the plasma membrane, causing oxidation of surface membrane lipids and membrane tension. This activates Piezo1 and TRP channels, making the membrane permeable to cations such as Na+ and Ca2+ while losing K+. In addition, the oxidation of lipids depresses the activity of the Na+/K+-ATPase, further disrupting cation gradients. Overall, increased membrane permeability to cations is a critical step in the execution of ferroptosis.
Article
Biochemistry & Molecular Biology
Wenbin Jia, Ichiro Kawahata, An Cheng, Takuya Sasaki, Toshikuni Sasaoka, Kohji Fukunaga
Summary: We confirmed that the FABP3 inhibitor, MF1, successfully reduces nicotine-induced conditioned place preference in mice. MF1 treatment decreased CPP scores in a dose-dependent manner by inhibiting the activation of CaMKII and ERK in the nucleus accumbens and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rikuhei Tsuchida, Daisuke Nishizawa, Ken-ichi Fukuda, Tatsuya Ichinohe, Kuniyuki Kano, Makoto Kurano, Kazutaka Ikeda, Masahiko Sumitani
Summary: A study on 362 healthy patients and 89 patients with cancer-related pain found that the ENPP2 gene polymorphisms rs7832704 and rs2249015 were significantly associated with opioid dose requirements, but not with postoperative pain intensity. This association was also validated in patients with cancer-related pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yuto Sekiguchi, Saya Takano, Takuya Noguchi, Tomohiro Kagi, Ryuto Komatsu, Maoko Tan, Yusuke Hirata, Atsushi Matsuzawa
Summary: In this study, gefitinib was found to activate the NLRP3 inflammasome through the activation of mitochondrial Src family kinases (mSFKs). All tested tyrosine kinase inhibitors were found to activate the NLRP3 inflammasome in human monocytic THP-1 cells and bone marrow-derived macrophages. These TKIs also exhibited off-target activity against mSFKs, such as c-Src, Fgr, and Fyn. These findings suggest that NLRP3 senses hypoactivity of mSFKs, resulting in mitochondrial dysfunction.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yusuke Hirata, Naoki Kashiwabara, Yuki Nada, Aya Inoue, Emiko Sato, Takuya Noguchi, Atsushi Matsuzawa
Summary: Through cell experiments, it was found that industrially sourced trans fatty acids (elaidic acid) have a strong pro-apoptotic effect, while ruminant-sourced trans fatty acids do not have this effect. Foods rich in polyunsaturated fatty acids can effectively suppress the toxic effects of industrially sourced trans fatty acids by targeting ASK1. This study provides a molecular basis for risk assessment and prevention and treatment strategies for TFA-related diseases.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Yusuke Hirata, Carla Ferreri, Yuto Yamada, Aya Inoue, Anna Sansone, Fabrizio Vetica, Wakana Suzuki, Saya Takano, Takuya Noguchi, Atsushi Matsuzawa, Chryssostomos Chatgilialoglu
Summary: Geometrical mono-trans isomers of arachidonic acid play a role in programmed cell death, particularly ferroptosis. Analysis of membrane fatty acid composition reveals the relationship between mono-trans isomers and cell fate in ferroptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)