Engineering the fragment crystallizable (Fc) region of human IgG1 multimers and monomers to fine-tune interactions with sialic acid-dependent receptors

The Emerging Importance of IgG Fab Glycosylation in Immunity

(2016) Fleur S. van de Bovenkamp et al.   JOURNAL OF IMMUNOLOGY

Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors

(2016) Daniel F. Ortiz et al.   Science Translational Medicine

The multiple facets of FcRn in immunity

(2015) Nigel M. Stapleton et al.   IMMUNOLOGICAL REVIEWS

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

(2015) Nathaniel Washburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection

(2015) X. Sewald et al.   SCIENCE

Diversity in structure and functions of antibody sialylation in the Fc

(2014) T Shantha Raju et al.   CURRENT OPINION IN BIOTECHNOLOGY

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

Impact of Immune Complex Size and Glycosylation on IgG Binding to Human Fc Rs

(2013) A. Lux et al.   JOURNAL OF IMMUNOLOGY

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

(2013) Xiaojie Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Beneficial effect of a multimerized immunoglobulin Fc in an animal model of inflammatory neuropathy (experimental autoimmune neuritis)

(2013) Marzieh Niknami et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Fc-fusion proteins: new developments and future perspectives

(2012) Daniel M. Czajkowsky et al.   EMBO Molecular Medicine

Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice

(2012) Ajay Jain et al.   ARTHRITIS RESEARCH & THERAPY

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

IVIg modulates BCR signaling through CD22 and promotes apoptosis in mature human B lymphocytes

(2010) J.-F. Seite et al.   BLOOD

The IgG molecule as a biological immune response modifier: Mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory disorders

(2010) Mark Ballow   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE