期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 292, 期 9, 页码 3543-3551出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R116.755694
关键词
cancer; deubiquitylation (deubiquitination); polyubiquitin chain; signal transduction; ubiquitylation (ubiquitination); monoubiquitination; non-degradative pathways; therapeutic intervention; ubiquitination; deubiquitination
资金
- BREAST-PREDICT, The Irish Cancer Society's Collaborative Cancer Research Centre [CCRC13GAL]
- Science Foundation Ireland
- OPTi-PREDICT project under the Investigator Programme [15/IA/3104]
The addition of ubiquitin to a target protein has long been implicated in the process of degradation and is the primary mediator of protein turnover in the cell. Recently, however, many non-proteolytic functions of ubiquitination have emerged as key regulators of cellular homeostasis. In this review, we will describe the various non-traditional functions of ubiquitination, with particular focus on how they can be used as signaling entities in cancer formation and progression. Elaboration of this topic can lead to a better understanding of oncogenic mechanisms, as well as the discovery of novel druggable proteins within the ubiquitin pathway.
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