ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage

ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor

(2017) Andrew T. Holdbrooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Glycosyltransferase ST6Gal-I Protects Tumor Cells against Serum Growth Factor Withdrawal by Enhancing Survival Signaling and Proliferative Potential

(2017) Colleen M. Britain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype

(2016) Matthew J. Schultz et al.   CANCER RESEARCH

Prognostic and predictive markers in pancreatic adenocarcinoma

(2016) Nha Le et al.   DIGESTIVE AND LIVER DISEASE

Importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation

(2016) Sicong Hou et al.   FASEB JOURNAL

New treatment strategy with nuclear factor-κB inhibitor for pancreatic cancer

(2016) Takashi Horiuchi et al.   JOURNAL OF SURGICAL RESEARCH

RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4

(2016) Marie K. Kirby et al.   Molecular Oncology

SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage

(2016) Xuehui Hong et al.   NUCLEIC ACIDS RESEARCH

Epidemiology of pancreatic cancer

(2016) Milena Ilic et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway

(2016) Xixi Chen et al.   Oncotarget

Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis

(2016) Chi-Che Hsieh et al.   Oncotarget

Defective hCNT1 transport contributes to gemcitabine chemoresistance in ovarian cancer subtypes: Overcoming transport defects using a nanoparticle approach

(2015) Sau Wai Hung et al.   CANCER LETTERS

Significance of β-Galactoside α2,6 Sialyltranferase 1 in Cancers

(2015) Jishun Lu et al.   MOLECULES

Targeted nuclear factor-kappaB suppression enhances gemcitabine response in human pancreatic tumor cell line murine xenografts

(2015) Joshua A. Waters et al.   SURGERY

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

β-Galactoside α2,6-Sialyltranferase 1 Promotes Transforming Growth Factor-β-mediated Epithelial-Mesenchymal Transition

(2014) Jishun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABC transporters in CSCs membranes as a novel target for treating tumor relapse

(2014) Laura Zinzi et al.   Frontiers in Pharmacology

ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells

(2013) Matthew J Schultz et al.   Journal of Ovarian Research

A curious case of oxaliplatin-induced neurotoxicity: Recurrent, self-limiting dysarthria

(2013) Ranjit Joseph et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells

(2012) Jung-Jin Park et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of the metastatic cell phenotype by sialylated glycans

(2012) Matthew J. Schultz et al.   CANCER AND METASTASIS REVIEWS

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Cleavage of ST6Gal I by Radiation-Induced BACE1 Inhibits Golgi-Anchored ST6Gal I-Mediated Sialylation of Integrin β1 and Migration in Colon Cancer Cells

(2012) Minyoung Lee et al.   Radiation Oncology

Harnessing gemcitabine metabolism: a step towards personalized medicine for pancreatic cancer

(2012) Muhammad Wasif Saif et al.   Therapeutic Advances in Medical Oncology

CNT1 Expression Influences Proliferation and Chemosensitivity in Drug-Resistant Pancreatic Cancer Cells

(2011) Y. D. Bhutia et al.   CANCER RESEARCH

Sialylation of the Fas Death Receptor by ST6Gal-I Provides Protection against Fas-mediated Apoptosis in Colon Carcinoma Cells

(2011) Amanda F. Swindall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ST6Gal-I Regulates Macrophage Apoptosis via α2-6 Sialylation of the TNFR1 Death Receptor

(2011) Zhongyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

(2011) Y.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

(2010) Ymera Pignochino et al.   BMC CANCER

Targeting AKT with the proapoptotic peptide, TAT-CTMP: A novel strategy for the treatment of human pancreatic adenocarcinoma

(2009) Peter O. Simon et al.   INTERNATIONAL JOURNAL OF CANCER

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

(2009) L. A. Parsels et al.   MOLECULAR CANCER THERAPEUTICS

The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition

(2008) A. Vigneron et al.   CANCER RESEARCH

Nuclear Factor- B p65/relA Silencing Induces Apoptosis and Increases Gemcitabine Effectiveness in a Subset of Pancreatic Cancer Cells

(2008) X. Pan et al.   CLINICAL CANCER RESEARCH

Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms

(2008) Faheem M. Shaikh et al.   EXPERIMENTAL CELL RESEARCH

ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function

(2008) Daniel R Christie et al.   Journal of Ovarian Research