Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding

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Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

(2017) Pascal Krotee et al.   eLife

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

(2016) Alice Soragni et al.   CANCER CELL

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The collection of MicroED data for macromolecular crystallography

(2016) Dan Shi et al.   Nature Protocols

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic resolution structure determination by the cryo-EM method MicroED

(2016) Shian Liu et al.   PROTEIN SCIENCE

Cross-Seeding Interaction between β-Amyloid and Human Islet Amyloid Polypeptide

(2015) Rundong Hu et al.   ACS Chemical Neuroscience

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly

(2015) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Uncovering the Mechanism of Aggregation of Human Transthyretin

(2015) Lorena Saelices et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Type 2 diabetes as a protein misfolding disease

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MicroED data collection and processing

(2015) Johan Hattne et al.   Acta Crystallographica A-Foundation and Advances

Monoclonal Antibodies against Aβ42 Fibrils Distinguish Multiple Aggregation State Polymorphismsin Vitroand in Alzheimer Disease Brain

(2014) Asa Hatami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution structure determination by continuous-rotation data collection in MicroED

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Better models by discarding data?

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Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases

(2013) Rodrigo Morales et al.   PLoS Pathogens

Three-dimensional electron crystallography of protein microcrystals

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The Amyloid State of Proteins in Human Diseases

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(2012) Rodrigo Morales et al.   Nature Protocols

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Dynamics of Amyloid β Fibrils Revealed by Solid-state NMR

(2011) Holger A. Scheidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo

(2011) Virginia Fonte et al.   Molecular Neurodegeneration

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

(2011) Stuart A. Sievers et al.   NATURE

Molecular basis for amyloid-  polymorphism

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Progressive deterioration of insulin secretion in Japanese type 2 diabetic patients in comparison with those who carry the S20G mutation of the islet amyloid polypeptide gene: A long-term follow-up study

(2011) Shuhei Morita et al.   Journal of Diabetes Investigation

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

(2010) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

(2010) Kawser Akter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A Promiscuous Prion: Efficient Induction of [URE3] Prion Formation by Heterologous Prion Domains

(2009) C. D. Ross et al.   GENETICS

Role of Amyloid-  Glycine 33 in Oligomerization, Toxicity, and Neuronal Plasticity

(2009) A. Harmeier et al.   JOURNAL OF NEUROSCIENCE

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

(2009) Jed J. W. Wiltzius et al.   PROTEIN SCIENCE

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of A  toxicity

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