Article
Gastroenterology & Hepatology
Ankit Malik, Jean M. Brudvig, Barbie J. Gadsden, Alexander D. Ethridge, Linda S. Mansfield
Summary: This study demonstrates the link between Campylobacter jejuni and the autoimmune disease Guillain-Barré syndrome and identifies the roles of Siglec-1 and IL-4 in its development. The mouse model developed in this study provides potential therapeutic interventions for this disease.
Review
Biochemistry & Molecular Biology
Josef Finsterer
Summary: Guillain-Barre syndrome is a rare neuro-immunological disorder that usually occurs after a previous gastrointestinal or respiratory infection. The most common triggers are infections, with Campylobacter jejuni, Mycoplasma pneumoniae, and cytomegalovirus being the most common infectious agents. The clinical presentation varies depending on the structure of pathogenic lipo-oligosaccharides. Molecular mimicry between pathogen surface structures and nerve components may explain the pathophysiology of GBS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Jessica L. St. Charles, Phillip T. Brooks, Julia A. Bell, Husnain Ahmed, Mia Van Allen, Shannon D. Manning, Linda S. Mansfield
Summary: This study found a close relationship between C. jejuni strains from sick calves and those infecting family members, suggesting zoonotic transmission. Additionally, despite repeated exposure to C. jejuni strains with LOS known to elicit autoimmune reactions, the family members did not develop GBS.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Norman Latov
Summary: Infection with Campylobacter jejuni (Cj) is found in approximately 30% of Guillain-Barre syndrome (GBS) patients, with a 77 to 100-fold increased risk of GBS following Cj infection. GBS is predominantly of the axonal subtype and is mediated by IgG antibodies to peripheral nerve gangliosides that cross-react with oligosaccharides in Cj lipopolysaccharides (LPS). The development of autoimmune disease is thought to be induced by molecular mimicry, where immune reactivity to a cross-reactive epitope in the infectious organism and normal tissue can occur. Cj infection can activate various inflammatory pathways, leading to immune tolerance disruption and autoimmune induction. Understanding the immune mechanisms involved in the development of autoantibodies and neuropathy would aid in comprehending the relationship between infection and autoimmunity and support the development of more effective preventive interventions and therapies.
Article
Microbiology
Willi Quino, Junior Caro-Castro, Orson Mestanza, Veronica Hurtado, Maria Luz Zamudio, Gloria Cruz-Gonzales, Ronnie G. Gavilan
Summary: This article describes the molecular epidemiology of C. jejuni strains (ST-2993) associated with a large Guillain-Barre Syndrome (GBS) outbreak in Peru, with a connection found between Peruvian and Chinese GBS strains through phylogenetic analysis. The study also revealed the presence of ST-2993 strains in isolates recovered before the outbreak, indicating a need for increased surveillance of C. jejuni to prevent future GBS outbreaks. The close relationship between human and chicken strains suggests chickens as a probable reservoir.
MICROBIOLOGY SPECTRUM
(2022)
Article
Clinical Neurology
Stephen Keddie, Duncan Smyth, Ryan Y. S. Keh, Michael K. L. Chou, Donna Grant, Sunaina Surana, Amanda Heslegrave, Henrik Zetterberg, Luuk Wieske, Milou Michael, Filip Eftimov, Roberto Bellanti, Simon Rinaldi, Melanie S. Hart, Axel Petzold, Michael P. Lunn
Summary: Valid blood biomarkers specific to peripheral nerve damage would greatly improve management of peripheral nervous system diseases. This study found that peripherin, an intermediate filament protein, could serve as a promising biomarker for peripheral nerve axonal damage. An immunoassay using single molecule array technology was developed to detect serum peripherin levels, and longitudinal analysis showed its potential clinical application in certain diseases.
Article
Clinical Neurology
Lotte S. Levison, Reimar W. Thomsen, Henning Andersen
Summary: This nationwide study aimed to investigate the association between hospital-diagnosed morbidity, recent surgery, and subsequent Guillain-Barre syndrome (GBS) development. The results showed that individuals with pre-existing hospital-diagnosed morbidity had a 1.6-fold increased risk of GBS compared to controls. The risk was highest for morbidities newly diagnosed within the past 5 months (4.1-fold increase). Additionally, individuals who had undergone surgical procedures within 5 months prior had a 2.2-fold increased risk of GBS, with the highest risk observed within the first month following surgery (3.7-fold increase).
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Lotte Sahin Levison, Reimar Wernich Thomsen, Henning Andersen
Summary: This study found a slightly increased risk of Guillain-Barre syndrome (GBS) within one month after influenza vaccination, based on a retrospective nationwide population-based case-control study in Denmark. However, only 1.5% of GBS cases were associated with recent influenza vaccination. Therefore, the benefits of influenza vaccines in preventing influenza infections and associated morbidity and mortality need to be evaluated against the small absolute risk of GBS.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Susumu Kusunoki, Hugh J. Willison, Bart C. Jacobs
Summary: Guillain-Barre syndrome and Fisher syndrome are acute autoimmune neuropathies often triggered by infection, with antiglycolipid antibody titres elevated in acute-phase patients, particularly for diagnosis in FS. These antibodies are mainly found in acute motor axonal neuropathy GBS and FS, suggesting the need for further research and standardisation in antibody detection methods.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Amber Hameed, Julian M. Ketley, Alexandra Woodacre, Lee R. Machado, Gemma L. Marsden
Summary: This study conducted a classification and frequency analysis of LOS genotypes in C. jejuni and C. coli. The results showed that class B is the most abundant LOS class in C. jejuni, while class III is the most abundant LOS locus type in C. coli.
Article
Medicine, General & Internal
Fang-e Shi, Mei-fang Chen, Yong-jie Li, Gui-ying Dong, Ji-hong Zhu
Summary: In this report, we describe a case of hemophagocytic lymphohistiocytosis (HLH) caused by C. jejuni infection, who presented with multiple clinical manifestations of peripheral nerve injury and was eventually diagnosed with Guillain-Barre Syndrome (GBS). After treatment with dexamethasone combined with immunoglobulin, the patient showed partial recovery of neurological symptoms.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Andreea-Raluca Hanganu, Alexandru Constantin, Elena-Sonia Moise, Cristian-Mihail Niculae, Ioana Diana Olaru, Cristian Baicus, Adriana Hristea
Summary: There is increasing evidence that COVID-19 can affect both the central and peripheral nervous systems, with a particular impact on the cranial nerves. Facial, vestibulo-cochlear, and olfactory nerves are the most frequently involved. Patients with peripheral nervous system involvement are more likely to be hospitalized and experience post-COVID-19 sequelae. Overall, the importance of this study is rated at 8 out of 10.
Article
Clinical Neurology
Johanna I. Hamel, Eric L. Logigian
Summary: This study retrospectively reviewed cases from 1999 to 2020 to describe the clinical, micronutrient, and electrophysiologic spectra and prognosis of acute nutritional axonal neuropathy (ANAN). The results showed that ANAN has a wide spectrum of manifestations and specific micronutrient deficiencies or risk factors do not predict neuropathy subtype. The prognosis of ANAN is guarded due to slow recovery of independent ambulation and residual neuropathic pain.
Editorial Material
Clinical Neurology
Sina Marzoughi, Laura Marulanda, Dian Ngo, Tychicus Chen
Summary: This case presents an atypical motor axonal neuropathy with asymmetric paralysis, initially preserved reflexes, rapid progression, and cardiac dysfunction independent of dysautonomia.
Editorial Material
Clinical Neurology
Jonah P. Zuflacht, Aimee K. Boegle
Summary: CIDP may present acutely, resembling GBS.
Review
Immunology
Ankit Malik, Thirumala-Devi Kanneganti
IMMUNOLOGICAL REVIEWS
(2018)
Article
Cell Biology
Deepika Sharma, Ankit Malik, Nandakumar Packiriswamy, Michael D. Steury, Narayanan Parameswaran
Article
Gastroenterology & Hepatology
Deepika Sharma, Ankit Malik, Clifford S. Guy, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti
Article
Public, Environmental & Occupational Health
S. Hasan Arshad, John W. Holloway, Wilfried Karmaus, Hongmei Zhang, Susan Ewart, Linda Mansfield, Sharon Matthews, Claire Hodgekiss, Graham Roberts, Ramesh Kurukulaaratchy
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2018)
Article
Immunology
Ankit Malik, Deepika Sharma, R. K. Subbarao Malireddi, Clifford S. Guy, Ti-Cheng Chang, Scott R. Olsen, Geoffrey Neale, Peter Vogel, Thirumala-Devi Kanneganti
Article
Medicine, Research & Experimental
Deepika Sharma, Ankit Malik, Clifford Guy, Peter Vogel, Thirumala-Devi Kanneganti
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Jiayou Liu, Jodi R. Parrish, Julie Hines, Linda Mansfield, Russell L. Finley
Article
Immunology
Phillip T. Brooks, Julia A. Bell, Christopher E. Bejcek, Ankit Malik, Linda S. Mansfield
JOURNAL OF NEUROIMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Sangman M. Kim, Jennifer R. DeFazio, Sanjiv K. Hyoju, Kishan Sangani, Robert Keskey, Monika A. Krezalek, Nikolai N. Khodarev, Naseer Sangwan, Scott Christley, Katharine G. Harris, Ankit Malik, Alexander Zaborin, Romain Bouziat, Diana R. Ranoa, Mara Wiegerinck, Jordan D. Ernest, Baddr A. Shakhsheer, Irma D. Fleming, Ralph R. Weichselbaum, Dionysios A. Antonopoulos, Jack A. Gilbert, Luis B. Barreiro, Olga Zaborina, Bana Jabri, John C. Alverdy
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Deepika Sharma, Ankit Malik, Arjun Balakrishnan, R. K. Subbarao Malireddi, Thirumala-Devi Kanneganti
JOURNAL OF IMMUNOLOGY
(2020)
Article
Microbiology
Azam A. Sher, John P. Jerome, Julia A. Bell, Julian Yu, Hahyung Y. Kim, Jeffrey E. Barrick, Linda S. Mansfield
FRONTIERS IN MICROBIOLOGY
(2020)
Meeting Abstract
Immunology
Deepika Sharma, Ankit Malik, Cliff Guy, Peter Vogel, Thirumala-Devi Kanneganti
JOURNAL OF IMMUNOLOGY
(2018)
Meeting Abstract
Immunology
Ankit Malik, Deepika Sharma, Peter Vogel, Thirumala-Devi Kanneganti
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)