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Pharmacology & Pharmacy
Liping Liao, Wenzhen Dang, Tingting Lin, Jinghua Yu, Tonghai Liu, Wen Li, Senhao Xiao, Lei Feng, Jing Huang, Rong Fu, Jiacheng Li, Liping Liu, Mingchen Wang, Hongru Tao, Hualiang Jiang, Kaixian Chen, Xingxing Diao, Bing Zhou, Xiaoyan Shen, Cheng Luo
Summary: PGK1 plays a role in immunometabolism by influencing metabolic status. The inhibitor DC-PGKI can suppress the activity of PGK1 and alleviate symptoms of inflammatory bowel disease.
ACTA PHARMACEUTICA SINICA B
(2022)
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Immunology
Mingya Cao, Lina Ma, Chenyang Yan, Han Wang, Mengzhe Ran, Ying Chen, Xiao Wang, Xiaonan Liang, Lihui Chai, Xia Li
Summary: The expression of Ocilrp2 in macrophages is regulated by LPS stimulation and VSV infection. Silencing Ocilrp2 results in increased IL-6 expression, while over-expression of Ocilrp2 leads to decreased IL-6 expression. Furthermore, the binding of Ocilrp2 to Syk plays a critical role in regulating the expression of inflammatory cytokines in macrophages.
FRONTIERS IN IMMUNOLOGY
(2022)
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Allergy
Aurora Holgado, Zhuangzhuang Liu, Aigerim Aidarova, Christina Mueller, Mira Haegman, Yasmine Driege, Marja Kreike, Charlotte L. Scott, Inna S. Afonina, Rudi Beyaert
Summary: IL-33 plays a crucial role in allergic diseases, and A20 is involved in regulating IL-33 signaling. In the absence of A20 in macrophages, IL-33-induced lung immune responses are altered, with reduced type 2 immune response and increased production of IFN-gamma. This study reveals a novel role for A20 in regulating IL-33-induced STAT1 signaling in macrophages.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
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Gastroenterology & Hepatology
Hannah M. Kolev, Avital Swisa, Elisabetta Manduchi, Yemin Lan, Rachel R. Stine, Giuseppe Testa, Klaus H. Kaestner
Summary: This study investigated the role of H3K27me3 demethylation in the intestine and found that the demethylases KDM6A/B are required for the full transcriptomic and epigenomic landscape of the intestinal epithelium and the expression of key Paneth cell genes.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
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Cell Biology
Mohammed Razeeth Shait Mohammed, Mazin Zamzami, Hani Choudhry, Firoz Ahmed, Bushra Ateeq, Mohammad Imran Khan
Summary: This study discovered that H3K27 histone demethylases, KDM6A/B, are highly expressed during ECM detachment. Inhibition of KDM6A/B activity reduces sphere formation capacity and increases apoptosis. KDM6B maintains stemness by transcriptionally regulating the expression of stemness genes and plays a regulatory role in maintaining hypoxia in detached cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
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Biochemistry & Molecular Biology
Daniela Andrea Paira, Silene Silvera-Ruiz, Andrea Tissera, Rosa Isabel Molina, Jose Javier Olmedo, Virginia Elena Rivero, Ruben Dario Motrich
Summary: The study suggests that inflammatory cytokines IFN-γ, IL-17A, and IL-1β can individually impair human sperm motility and decrease viability, leading to increased apoptosis. On the other hand, IL-8 does not have a significant impact on sperm.
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Immunology
Nadeem Akhter, Shihab Kochumon, Amal Hasan, Ajit Wilson, Rasheeba Nizam, Ashraf Al Madhoun, Fatema Al-Rashed, Hossein Arefanian, Fawaz Alzaid, Sardar Sindhu, Fahd Al-Mulla, Rasheed Ahmad
Summary: The co-stimulation of IFN-gamma and LPS can enhance the expression of CCL2 through the acetylation of H3K27, leading to augmented inflammation in obesity. These findings contribute to a better understanding of the regulatory mechanisms of CCL2 in the pathogenesis of obesity.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
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Oncology
Xiao Cui, Huiyong Zhao, Sheng Wei, Qiang Du, Kun Dong, Yihe Yan, David. A. Geller
Summary: The study found that tumor-derived FOXO1 is negatively correlated with the distribution of protumor macrophages (TAMs). FOXO1 inhibits tumorigenesis by targeting tumor cells and synchronizing with re-educated macrophages. This effect is partially dependent on FOXO1 modulating the IRF-1/NO axis and decreasing IL-6 release in macrophages, ultimately suppressing the progression of HCC.
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Cell & Tissue Engineering
Chenyang Liu, Yan Xu, Yichi Lu, Pan Du, Xiaoxiao Li, Chengchun Wang, Peng Guo, Ling Diao, Guozhong Lu
Summary: The study demonstrates that S-IT MSCs can effectively induce M2 polarization of macrophages via IL-6 dependent signaling pathways and accelerate wound healing. Results show that S-IT MSCs significantly enhance the ability of M2 phenotype to promote vascularization and collagen deposition, ultimately improving wound healing quality.
STEM CELL RESEARCH & THERAPY
(2022)
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Biochemistry & Molecular Biology
Edyta Makuch, Izabella Jasyk, Anna Kula, Tomasz Lipinski, Jakub Siednienko
Summary: IFN-I plays a crucial role in activating and modulating the immune response to bacterial and viral pathogens. It promotes the expression of IFN-induced genes and chemokines, such as CXCL10, which are important for immune cell migration and localization during infection. Pellino3 acts as an E3 ubiquitin ligase and positively regulates the expression and secretion of IFN beta. This study reveals that Pellino3 is also involved in the regulation of CXCL10 expression through the phosphorylation and nuclear translocation of the STAT1/STAT2/IRF9 complex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
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Multidisciplinary Sciences
Kathrine Gotfredsen, Charlotte Liisborg, Vibe Skov, Lasse Kjaer, Hans Carl Hasselbalch, Torben Lykke Sorensen
Summary: Immune responses play a key role in the pathogenesis and progression of MPN and AMD. This study found that serum levels of IL-4 and IL-33 may be involved in drusen development in MPN patients, supporting the association between chronic inflammation and drusen.
SCIENTIFIC REPORTS
(2023)
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Pharmacology & Pharmacy
Prajakta Kalkar, Gal Cohen, Tal Tamari, Sagie Schif-Zuck, Hadar Zigdon-Giladi, Amiram Ariel
Summary: The combination of Zoledronic acid and dexamethasone can block osteoclast differentiation by increasing the expression of IFN-beta, potentially leading to the development of IFN-beta-based therapy to inhibit osteoclastogenesis in multiple myeloma patients.
FRONTIERS IN PHARMACOLOGY
(2022)
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Immunology
Rita Haldar, Lee Shaashua Berger, Ella Rossenne, Arielle Radin, Anabel Eckerling, Elad Sandbank, Erica K. Sloan, Steve W. Cole, Shamgar Ben-Eliyahu
Summary: We demonstrated that minimally-invasive removal of primary tumors (PTs) and elimination of secreted factors can induce regression of micro-metastases in breast cancer. However, laparotomy during the procedure leads to an outbreak of micro-metastases. Administration of propranolol and etodolac can maintain metastatic dormancy following laparotomy.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
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Cardiac & Cardiovascular Systems
Justin P. Van Beusecum, Natalia R. Barbaro, Charles D. Smart, David M. Patrick, Roxana Loperena, Shilin Zhao, Nestor de la Visitacion, Mingfang Ao, Liang Xiao, Cyndya A. Shibao, David G. Harrison
Summary: This study demonstrates an increase in circulating AS DCs in hypertensive patients, with Axl signaling playing a critical role in promoting their formation. The research also reveals the significant involvement of GAS6 and Axl signaling in immune cells and endothelial cells in hypertension.
CIRCULATION RESEARCH
(2021)
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Endocrinology & Metabolism
Danny Luan, Benyamin Dadpey, Jessica Zaid, Pania E. Bridge-Comer, Julia H. DeLuca, Wenmin Xia, Joshua Castle, Shannon M. Reilly
Summary: The bidirectional interaction between adipocytes and adipose tissue immune cells is crucial for regulating adipose function, inflammation, and insulin responsiveness. Obesity reduces cAMP-driven IL-6 secretion from adipocytes, but restoring their catecholamine sensitivity can stimulate IL-6 secretion and activate macrophages to promote an anti-inflammatory gene expression pattern.
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Cell Biology
Xiuduan Xu, Hongli Wang, Shasha Liu, Chen Xing, Yang Liu, Aodengqimuge, Wei Zhou, Xiaoyan Yuan, Yongfu Ma, Meiru Hu, Yongliang Hu, Shuxian Zou, Ye Gu, Shuangqing Peng, Shengtao Yuan, Weiping Li, Yuanfang Ma, Lun Song
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Immunology
Que Deng, Hongyu Chen, Yanjun Liu, Fengjun Xiao, Lang Guo, Dan Liu, Xiang Cheng, Min Zhao, Xiaomeng Wang, Shuai Xie, Siyong Qi, Zhaoyang Yin, Jiangping Gao, Xintian Chen, Jiangong Wang, Ning Guo, Yuanfang Ma, Ming Shi
BRAIN BEHAVIOR AND IMMUNITY
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Biochemistry & Molecular Biology
Xiukun Cui, Huiyuan Liu, Jing Li, Kangwen Guo, Wenxiu Han, Yi Dong, Simin Wan, Xuance Wang, Panpan Jia, Shulian Li, Yuanfang Ma, Jun Zhang, Hongmei Mu, Yanzhong Hu
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2016)
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Microbiology
Qiang Lou, Yuanfang Ma, Di Qu
JOURNAL OF BASIC MICROBIOLOGY
(2016)
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Oncology
Yaohui Wang, Yinan Jiang, Jinxue Zhou, Wuhui Song, Jing Li, Mingli Wang, Jiuge Chen, Rui Xu, Jingjing Zhang, Fanni Ma, Youhai H. Chen, Yuanfang Ma
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Oncology
Silei Zhou, Huanling Cao, Yawei Zhao, Xinying Li, Jiyan Zhang, Chunmei Hou, Yuanfang Ma, Qingyang Wang
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Oncology
Xingwei Jiang, Tingting Zhou, Yan Xiao, Jiahui Yu, Shuaijie Dou, Guojiang Chen, Renxi Wang, He Xiao, Chunmei Hou, Wei Wang, Qingzhu Shi, Jiannan Feng, Yuanfang Ma, Beifen Shen, Yan Li, Gencheng Han
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Immunology
Wei Wang, Qingzhu Shi, Shuaijie Dou, Ge Li, Xinhui Shi, Xingwei Jiang, Zhiding Wang, Dandan Yu, Guojiang Chen, Renxi Wang, He Xiao, Chunmei Hou, Jiannan Feng, Beifen Shen, Yuanfang Ma, Gencheng Han
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Biochemistry & Molecular Biology
Yinan Jiang, Xiaoyan Chen, Mengya Fan, Hui Li, Weina Zhu, Xi Chen, Chenghua Cao, Rui Xu, Yaohui Wang, Yuanfang Ma
MOLECULAR IMMUNOLOGY
(2017)
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Biochemistry & Molecular Biology
Ning Ma, Yu Zhang, Qilin Liu, Zhiding Wang, Xiaoling Liu, Gaizhi Zhu, Dandan Yu, Gencheng Han, Guojiang Chen, Chunmei Hou, Tianxiao Wang, Yuanfang Ma, Beifen Shen, Yan Li, He Xiao, Renxi Wang
MOLECULAR IMMUNOLOGY
(2017)
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Immunology
Zhiguang Ren, Yongkun Zhao, Jing Liu, Xianliang Ji, Lingnan Meng, Tiecheng Wang, Weiyang Sun, Kun Zhang, Xiaoyu Sang, Zhijun Yu, Yuanguo Li, Na Feng, Hualei Wang, Songtao Yang, Zhengyan Yang, Yuanfang Ma, Yuwei Gao, Xianzhu Xia
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
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Cell Biology
Hailong Zhang, Xi Chen, Beibei Zong, Hongmin Yuan, Zhizeng Wang, Yinxiang Wei, Xuance Wang, Guangchao Liu, Jun Zhang, Shulian Li, Guanchang Cheng, Yaohui Wang, Yuanfang Ma
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
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Gastroenterology & Hepatology
Lanju Wang, Yaohui Wang, Zhenfeng Wang, Yu Qi, Beibei Zong, Meichen Liu, Xuefang Li, Xingkun Zhang, Chengguo Liu, Run Cao, Yuanfang Ma
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2018)
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Oncology
Hongyu Chen, Wei Zhang, Xiang Cheng, Liang Guo, Shuai Xie, Yuanfang Ma, Ning Guo, Ming Shi
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Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
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Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)