Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Nutrition & Dietetics
Lingsi Zeng, Honggang Lv, Xubo Wang, Ranran Xue, Cong Zhou, Xia Liu, Hao Yu
Summary: Using Mendelian randomization (MR) analysis, this study found potential causal relationships between levels of fatty acids (FA) and the risk of depression. Specifically, oleic acid (OA) and alpha-linolenic acid (ALA) were identified as potential risk factors for depression, while adrenic acid and eicosapentaenoic acid (EPA) were found to be protective. These findings emphasize the importance of further research to investigate the underlying mechanisms that mediate the association between these fatty acids and depression risk.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Anna Wyrostek, Katarzyna Czyz, Ewa Sokola-Wysoczanska, Bozena Patkowska-Sokola, Wieslaw Bielas
Summary: This study examined the effect of supplementation with ethyl esters of linseed oil on the fatty acid profile in blood serum, erythrocyte membranes, and hair sebum of healthy beagle dogs. The results showed that the supplementation decreased the content of saturated fatty acids and increased the level of beneficial unsaturated fatty acids, especially those from the omega-3 family.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Editorial Material
Food Science & Technology
Emanuele Rinninella, Lara Costantini
Summary: The International Scientific Association for Probiotics and Prebiotics (ISAPP) considers polyunsaturated fatty acids (PUFAs) as candidate prebiotics, although there is a lack of complete scientific evidence. Recent partial evidence shows that metabolites of PUFAs can have important health effects in the host, supporting the concept of the prebiotic action of PUFAs.
Review
Food Science & Technology
Ismael Rodriguez-Gonzalez, Beatriz Diaz-Reinoso, Herminia Dominguez
Summary: Marine organisms are valuable sources of long-chain omega-3 polyunsaturated fatty acids, which are increasingly in demand for their health benefits. Seaweeds have a low lipid content, but their high PUFA fraction and low omega-6:omega-3 ratio make them an alternative source. Concentrated lipid extracts provide a practical method without significantly changing dietary habits. The extraction technology plays a key role in the production of seaweed extracts, and the choice of solvent and operational conditions can also extract other lipophilic components, resulting in a final product with interesting biological properties. Utilizing the remaining algal solids as a source of additional nutritional and bioactive compounds is essential for achieving a sustainable process.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Article
Oncology
Iman Moussa, Rena S. Day, Ruosha Li, Ahmed Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M. Hassan
Summary: This study found an inverse association between monounsaturated fatty acid intake and hepatocellular carcinoma (HCC) risk, and a direct association between total polyunsaturated fatty acid intake and HCC risk. Omega-6 PUFA intake was directly associated with HCC risk, while long-chain omega-3 PUFA intake was inversely associated with HCC risk. No significant association was observed for saturated fat and HCC risk.
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Review
Food Science & Technology
Siddhant Dubey, Chiu-Wen Chen, Anil Kumar Patel, Shashi Kant Bhatia, Reeta Rani Singhania, Cheng-Di Dong
Summary: This review summarizes the research advancements in microalgae PUFA production and discusses the potential applications. Various cultivation modes, including heterotrophic, mixotrophic, and photoheterotrophic, are assessed for cost-effective PUFA production. Parameters such as salinity, nutrients, carbon source, and light intensity have significant effects on PUFA accumulation.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Agriculture, Dairy & Animal Science
Mario Francisco Oviedo-Ojeda, Jose Alejandro Roque-Jimenez, Megan Whalin, Hector Aaron Lee-Rangel, Alejandro Enrique Relling
Summary: Supplementing with unsaturated fatty acids during early pregnancy can alter the productive performance and mRNA expression of neuropeptides in offspring, showing that the interaction of different sources of fatty acids and different stages can affect growth in lambs.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Hematology
Adriana Yamaguchi, Livia Stanger, Cody J. Freedman, Melissa Standley, Timothy Hoang, Reheman Adili, Wan-Chen Tsai, Christopher van Hoorebeke, Theodore R. Holman, Michael Holinstat
Summary: DHA and its 12-LOX oxylipins, 11-HDHA and 14-HDHA, attenuate platelet aggregation, inhibit IIb β3 activation, decrease α-granule secretion, impair platelet adhesion and accumulation, and inhibit thrombus formation. The protective mechanism of DHA oxylipins is mediated via activation of protein kinase A, supporting their use as therapeutic intervention in atherothrombotic diseases.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
