期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 20, 期 4, 页码 361-373出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2017.1394292
关键词
Rutin; pirarubicin; cardiotoxicity; antioxidant; anti-apoptotic
We established both an acute and chronic cardiac toxicity rat model, which showed pretreatment with rutin attenuated pirarubicin-induced myocardial histopathological injury, electrocardiogram abnormalities, and cardiac dysfunction. Rutin also significantly reduced serum levels of MDA, BNP, CK-MB, CTnT, and LDH and increased serum SOD levels. Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p < 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p < 0.05). Furthermore, rutin at a dose of 50 mg/kg significantly attenuated the above-mentioned alterations. Our study suggests the antioxidant and anti-apoptotic properties of rutin may be responsible for the cardioprotective effects observed. [GRAPHICS] .
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