Article
Clinical Neurology
M. Balasch-Bernat, E. Lluch, H. B. Vaegter, L. Duenas
Summary: This study compared the effects of painful versus non-painful isometric shoulder exercises on individuals with rotator cuff-related shoulder pain. Both types of exercises caused a moderate increase in shoulder pain, but the effects were relatively short-lasting.
Article
Medicine, Research & Experimental
Anelise Sonza, Luciana Sayuri Sanada, Luiza Raulino de Oliveira, Mario Bernardo-Filho, Danubia da Cunha de Sa-Caputo, Milton Antonio Zaro, Matilde Achaval
Summary: The study revealed that whole-body vibration treatment has an effect on chronic pain model, reducing mechanical sensitivity and thermal sensitivity.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Shenbin Liu, Zhifu Wang, Yangshuai Su, Lu Qi, Wei Yang, Mingzhou Fu, Xianghong Jing, Yanqing Wang, Qiufu Ma
Summary: The study reveals that the specificity of sensory neurons is crucial for driving specific autonomic pathways and anti-inflammatory effects at specific acupoints.
Review
Immunology
Daniel B. Lowy, Preet G. S. Makker, Gila Moalem-Taylor
Summary: Bidirectional interaction between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. The skin is a highly complex biological structure where sensory nerve terminals and immune cells coexist. Sensory neurons regulate cutaneous immune responses through neuropeptides, while immune cells modulate sensory neurons through mediators.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Peungchaleoy Thammanichanon, Aunwaya Kaewpitak, Thunwa Binlateh, Prasit Pavasant, Chidchanok Leethanakul
Summary: The study found that continuous orthodontic force significantly increased pain behaviors at 1 and 3 days, while NF-kappa B levels significantly increased from 12 hours to 3 days. TRPV1 significantly elevated within 1 day, TRPA1 increased from 1 to 3 days, and CGRP expression increased from 12 hours to 3 days. The activation of TRPV1 and TRPA1 sensitizes trigeminal neurons, leading to CGRP release.
ARCHIVES OF ORAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roxana-Olimpia Gheorghe, Andreea Violeta Grosu, Melania Bica-Popi, Violeta Ristoiu
Summary: Traumatic peripheral neuropathic pain is a complex syndrome caused by primary peripheral nervous system dysfunction or damage. The interaction between neurons and macrophages plays a crucial role in pain development and chronicization, but it can also promote injury resolution and pain reduction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Javier Aguilera-Lizarraga
Summary: Abdominal pain, a common symptom worldwide, often occurs after food ingestion. Current treatment strategies mainly focus on excluding culprit food(s) from the diet. However, this approach has limitations, as patients may recognize multiple food items and not all offending foods can be identified. Newly identified mechanisms involving neuroimmune interactions and intestinal microbiota communication are important for developing new therapeutic strategies.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Sport Sciences
Bao Wu, Lili Zhou, Changcheng Chen, Juan Wang, L. Hu, Xueqiang Wang
Summary: This study aimed to explore the effects of isometric exercise on pain perception and its neural mechanisms. The results showed that high-intensity isometric exercise was more effective in reducing pain sensitivity compared to low-intensity exercise, and it also reduced the amplitudes of heat-evoked brain responses. This suggests that isometric exercise may modulate pain information transmission through a spinal gating mechanism and a top-down descending pain inhibitory mechanism.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Medicine, General & Internal
Dmitriy Viderman, Karina Tapinova, Fatima Nabidollayeva, Ramil Tankacheev, Yerkin G. Abdildin
Summary: This study compares the use of intravenous and epidural routes for patient-controlled analgesia in abdominal surgery. The results show that there is no significant difference in pain control and side effects between the two methods. However, epidural analgesia is associated with a shorter length of hospital stay, while intravenous analgesia is associated with fewer episodes of hypotension.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
X. Yan, J. Sun, Y. Zhang, Z. Zhao, L. Wang, J. Niu, X. Jia, Z. Zhang, X. Han, Y. Shao, Z. Guo
Summary: This study demonstrates a ferroelectric memristor with brain-like synaptic behavior, capable of multilevel storage and ultra-fast pulse conductance modulation. It successfully mimics synaptic properties and can emulate pain perception with low threshold and fast operation. The device holds promise for electronic skins, neurorobotics, and human-computer interaction technologies.
MATERIALS TODAY NANO
(2023)
Review
Biochemistry & Molecular Biology
Piotr Kaczmarski, Filip Franciszek Karuga, Bartosz Szmyd, Marcin Sochal, Piotr Bialasiewicz, Dominik Strzelecki, Agata Gabryelska
Summary: There is an association between obstructive sleep apnea (OSA) and pain modulation, which is related to the pathophysiological changes in OSA and various pain mechanisms. Characteristic changes in OSA, such as nocturnal hypoxemia, sleep fragmentation, and systemic inflammation, have a curtailing impact on pain perception. Pain management in OSA patients may cause problems due to alterations in neuropeptide systems and overexpression of opioid receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Victor Domenech-Garcia, Shellie Ann Boudreau, Rafael Giner-Nicolas, Pablo Bellosta-Lopez
Summary: Acute musculoskeletal injuries result in changes in swelling, redness, hyperalgesia, and expanded pain distribution. This study assessed mechanical muscle hyperalgesia, skin temperature, and pain intensity and distribution during the recovery process following eccentric exercise in the hamstring muscles. The results showed that pain-related variables and thermographic changes had different recovery times.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Anesthesiology
Michael Morgan, Jenny Thai, Vida Nazemian, Richard Song, Jason J. Ivanusic
Summary: This study explored the role of innervation of knee joint articular tissues and surrounding bone in osteoarthritis (OA) pain. The findings suggest that early OA pain is driven by nerves that innervate the joint capsule, while late OA pain involves the recruitment of nerves that innervate the subchondral bone. These results highlight the importance of targeting bone innervation for the development of mechanism-based therapies for late OA pain.
Review
Orthopedics
Lynn Tan, Flavia M. Cicuttini, Jessica Fairley, Lorena Romero, Mahnuma Estee, Sultana Monira Hussain, Donna M. Urquhart
Summary: This systematic review found evidence that aerobic exercise reduces pain sensitisation in individuals with musculoskeletal pain. Aerobic exercise involved walking or cycling at a submaximal intensity but with incremental increases, lasting for 4-60 minutes. The findings provide evidence for improved patient outcomes.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Immunology
Darine Fakih, Adrian Guerrero-Moreno, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Stephane Melik Parsadaniantz
Summary: The study evaluated the effectiveness of TRPV1 blockade in alleviating ocular pain, neuroinflammation, and anxiety-like behaviors associated with severe DED. Results showed that TRPV1 antagonist reduced corneal responsiveness to various stimuli and inhibited the upregulation of genes involved in neuropathic and inflammatory pain in the TG, leading to reduced ocular pain sensation and anxiety-like behaviors in severe DED.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Rheumatology
Mitchell T. Gibbs, Natalie M. Morrison, Matthew D. Jones, Danielle Burgess, Paul W. Marshall
Summary: This study examines the effectiveness of a modified fear hierarchy on measuring improvements in movement-associated fear in patients with chronic low back pain. The results demonstrate that reductions in movement-associated fear are conditional upon graded exposure, with different training methods leading to different improvements in specific movements.
MUSCULOSKELETAL CARE
(2023)
Review
Rehabilitation
Sally Casson, Matthew D. Jones, Joanne Cassar, Natalie Kwai, Andrew R. Lloyd, Benjamin K. Barry, Carolina X. Sandler
Summary: Activity pacing interventions are effective in reducing fatigue and psychological distress and improving physical function in people with chronic fatigue syndrome (CFS), particularly when individuals are encouraged to gradually increase activities.
DISABILITY AND REHABILITATION
(2023)
Review
Rheumatology
Adrian K. Ram, Simon J. Summers, John Booth, Mitchell T. Gibbs, Matthew D. Jones
Summary: This systematic review aimed to determine the effect of exercise intensity on outcomes in people with chronic low back pain. The review found that higher intensity exercise can reduce disability, but does not significantly improve pain and quality of life. The evidence quality was low, leading to uncertainty in the conclusions.
MUSCULOSKELETAL CARE
(2023)
Article
Sport Sciences
Ricardo N. O. Mesquita, Christopher Latella, Cassio V. Ruas, Kazunori Nosaka, Janet L. Taylor
Summary: The study compared different formulas used to estimate muscle contraction velocity (Vc) assessed by tensiomyography. The reliability, required minimum number of trials, proportional bias, and effects of joint angle were investigated. The results showed that formulas 1 (0-2 mm of displacement) and 5 (normalized to 10-90% of maximal displacement) had higher reliability. A minimum of 6-7 trials was required for reliable estimates. The study also found that Vc was faster at shorter muscle lengths for all formulas except formula 5. Different formulas should not be used interchangeably and more precise nomenclature is needed to describe the information obtained from each formula.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Review
Medicine, General & Internal
Michael A. Wewege, Matthew K. Bagg, Matthew Jones, Michael C. Ferraro, Aidan G. Cashin, Rodrigo R. N. Rizzo, Hayley B. Leake, Amanda D. Hagstrom, Saurab Sharma, Andrew J. McLachlan, Christopher G. Maher, Richard Day, Benedict M. Wand, Neil E. O'Connell, Adriani Nikolakopolou, Siobhan Schabrun, Sylvia M. Gustin, James H. McAuley
Summary: This study evaluated the comparative effectiveness and safety of analgesic medicines for acute non-specific low back pain through a systematic review and network meta-analysis. The results showed that the effectiveness and safety of analgesic medicines for acute non-specific low back pain are uncertain, and higher quality randomized controlled trials are needed for head-to-head comparisons.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Rheumatology
Elise E. Drum, Alexandre Kovats, Matthew D. Jones, Sarah Dennis, Justine Naylor, Kathryn Mills, Jeanette M. Thom
Summary: This study aimed to investigate the perceptions of knee crepitus and its impact on exercise behaviors among individuals with osteoarthritis. The findings suggest that most participants were not concerned about knee crepitus, but it did influence their exercise habits and movements. Providing guidance and support to individuals with concerns about knee crepitus may help them feel more confident in exercising for joint health benefits.
MUSCULOSKELETAL CARE
(2023)
Article
Neurosciences
Ricardo N. O. Mesquita, Janet L. Taylor, Gabriel S. Trajano, Ales Holobar, Basilio A. M. Goncalves, Anthony J. Blazevich
Summary: The study aimed to investigate whether jaw clenching and mental stress facilitate the activation of persistent inward currents (PICs) in human motoneurons. The results showed that PIC activation significantly increased during jaw clenching and in some cases of mental stress.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychiatry
Matthew D. Jones, Sally M. Casson, Benjamin K. Barry, Sophie H. Li, Trinidad Valenzuela, Joanne Cassar, Camillo Lamanna, Andrew R. Lloyd, Carolina X. Sandler
Summary: eLearning has been shown to increase knowledge and confidence among allied health professionals in managing patients with medically unexplained chronic fatigue states.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Orthopedics
Mitchell T. Gibbs, Jill A. Hayden, Aidan G. Cashin, Brishna Shah, Yannick L. Gilanyi, Andrew Natoli, Grant Holmes, Rachel Ogilvie, Amanda D. Hagstrom, James H. McAuley, Paul W. Marshall, Matthew D. Jones
Summary: This study aimed to estimate the proportion of exercise interventions tested in clinical trials for chronic low back pain (CLBP) that meet the World Health Organisation's (WHO) physical activity guidelines. A secondary analysis of the 2021 Cochrane review of exercise therapy for CLBP was performed, and the results showed that few interventions meet the WHO guidelines, indicating a lack of broader impact on health outcomes.
Article
Orthopedics
Harrison J. Hansford, Matthew D. Jones, Aidan G. Cashin, Raymond W. J. G. Ostelo, Alessandro Chiarotto, Sam A. Williams, Saurab Sharma, Jack J. Devonshire, Michael C. Ferraro, Michael A. Wewege, James H. Mcauley
Summary: The smallest worthwhile effect of nonsteroidal anti-inflammatory drugs (NSAIDs) and individualized exercise therapy for acute and chronic low back pain is approximately a 20 to 30% reduction in pain intensity. These findings can inform the use of NSAIDs and exercise in the treatment of low back pain.
JOURNAL OF PHYSIOTHERAPY
(2023)
Review
Medicine, General & Internal
Harrison J. Hansford, Aidan G. Cashin, Matthew D. Jones, Sonja A. Swanson, Nazrul Islam, Susan R. G. Douglas, Rodrigo R. N. Rizzo, Jack J. Devonshire, Sam A. Williams, Issa J. Dahabreh, Barbra A. Dickerman, Matthias Egger, Xabier Garcia-Albeniz, Robert M. Golub, Sara Lodi, Margarita Moreno-Betancur, Sallie-Anne Pearson, Sebastian Schneeweiss, Jonathan A. C. Sterne, Melissa K. Sharp, Elizabeth A. Stuart, Miguel A. Hernan, Hopin Lee, James H. Mcauley
Summary: The reporting of observational studies that aim to emulate a target trial is inconsistent, and the development of a reporting guideline may improve the quality of reporting.
Article
Rheumatology
Mitchell T. Gibbs, Theo Last, Paul Marshall, Matthew D. Jones
Summary: Practitioners' attitudes and beliefs towards chronic low back pain influence their treatment choices, with higher biomedical beliefs being associated with specific exercise and manual therapy, while higher biopsychosocial beliefs are related to general exercise and cognitive behavioral therapy.
MUSCULOSKELETAL CARE
(2023)
Article
Multidisciplinary Sciences
Claire V. Burley, Anne-Nicole Casey, Matthew D. Jones, Kemi E. Wright, Belinda J. Parmenter
Summary: This meta-analysis examined nonpharmacological interventions for pain and depression in people with osteoarthritis. The results showed significant effects of movement meditation, multimodal interventions, and psychological therapy in reducing pain. Resistance exercise and aerobic exercise alone did not improve pain. For depressive symptoms, movement meditation and multimodal interventions had significant effects.
SCIENTIFIC REPORTS
(2023)
Review
Anesthesiology
Adrian Ram, John Booth, Jeanette M. Thom, Mitchell T. Gibbs, Matthew D. Jones
Summary: The findings of this systematic review and meta-analysis suggest that there is no short-term association between changes in pain knowledge after pain science education and treatment outcomes in people with chronic pain.
CLINICAL JOURNAL OF PAIN
(2023)