Article
Cell & Tissue Engineering
Man Amanat, Anahita Majmaa, Morteza Zarrabi, Masoumeh Nouri, Masood Ghahvechi Akbari, Ali Reza Moaiedi, Omid Ghaemi, Fatemeh Zamani, Sharif Najafi, Reza Shervin Badv, Massoud Vosough, Amir Ali Hamidieh, Mona Salehi, Hadi Montazerlotfelahi, Ali Reza Tavasoli, Morteza Heidari, Hossein Mohebi, Ali Fatemi, Amir Garakani, Mahmoud Reza Ashrafi
Summary: The study showed that intrathecal injection of umbilical cord tissue mesenchymal stem cells (UCT-MSC) in individuals with cerebral palsy (CP) was safe and led to improvements in gross motor function and quality of life assessments. Diffusion tensor imaging (DTI) also indicated positive changes in white matter integrity, supporting the clinical improvements observed.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Susan Hastings, Hui Zhong, Rochel Feinstein, Gittel Zelczer, Christel Mitrovich, Parag Gad, V. Reggie Edgerton
Summary: Cerebral Palsy (CP) is a common pediatric motor disability. This study explored the use of an intervention combining non-invasive spinal neuromodulation with neurorehabilitation therapy to improve voluntary sensory-motor function in CP children. The intervention was associated with significant improvement in gross motor function.
NATURE COMMUNICATIONS
(2022)
Article
Pediatrics
Bhooma R. Aravamuthan, Darcy Fehlings, Sheetal Shetty, Michael Fahey, Laura Gilbert, Ann Tilton, Michael C. Kruer
Summary: The study identified practice variability in the diagnosis of cerebral palsy, especially in cases of nonprogressive motor disability caused by genetic factors or hypotonia. Despite anchoring questions with the 2007 consensus definition of CP, there was still disagreement among practitioners. Ways to reduce diagnostic variability have been suggested, including clarifying the consensus definition.
Article
Veterinary Sciences
Alexandra N. Stergiou, Sanna Mattila-Rautiainen, Dimitrios N. Varvarousis, Meropi Tzoufi, Panagiota Plyta, Alexandros Beris, Avraam Ploumis
Summary: This study evaluates the efficacy of Equine Assisted Therapy in children with Cerebral Palsy, focusing on gross motor function, performance, and spasticity, as well as the long-term effects. The results show that Equine Assisted Therapy significantly improves gross motor function and performance in children with Cerebral Palsy. However, no significant improvement is observed in spasticity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Orthopedics
Philippe Wagner, Gunnar Hagglund
Summary: This study analyzed the early development of hip surveillance in children with cerebral palsy, finding that hips in need of preventive surgery showed an increasing trend in MP, while hips stabilized without surgery showed a decreasing displacement rate.
Article
Multidisciplinary Sciences
Justine Laureau, Christelle Pons, Guy Letellier, Raphael Gross
Summary: This study reports the current evidence on the effectiveness of hyperbaric oxygen therapy (HBOT) for children with cerebral palsy (CP) and its safety. The findings suggest that HBOT is ineffective in improving motor and cognitive functions in children with CP, and it is associated with a higher rate of adverse events compared to pressurized air.
Article
Multidisciplinary Sciences
Xiaobin Hou, Yanyun Yan, Qijia Zhan, Junlu Wang, Bo Xiao, Wenbin Jiang
Summary: This study retrospectively reviewed 135 pediatric patients diagnosed with spastic cerebral palsy (SCP) who underwent selective dorsal rhizotomy (SDR) and found that SDR can reduce spasticity and improve motor function. Uns supervised machine learning methods were used to subgroup the patients into three clusters, which can predict the possible outcome of SDR.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Karen A. Horridge, Rory J. Tinker, Carl J. Harvey, Gavin DeKiewiet, Sam Munro, Lorna K. Fraser
Summary: The study explored the association between MRICS categorization and the burden of acute hospital admissions among children with cerebral palsy. Specific MRICS categories were found to be linked with higher inpatient days and risks of admissions, while others appeared to lessen the risk. MRICS B3 was identified as a potential risk factor for premature death, especially in older children with CP.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Orthopedics
Philippe Wagner, Gunnar Hagglund
Summary: The study compared the effects of adductor-psoas lengthening (APL) and varus derotation osteotomy (VDRO) on hip displacement in cerebral palsy patients. After APL, hip displacement gradually decreased, while after VDRO, there was an instantaneous decrease followed by a gradual increase.
Article
Orthopedics
Kimberley S. Scott, Gardenia O. Barbosa, Jeff Pan, Jill C. Heathcock
Summary: This study aimed to determine the relationship between parent-reported motor performance using the PODCI and motor capacity assessed by pediatric therapists for young children with CP across all ability levels, as well as explore the use of the PODCI expectations scale for quantifying therapy-related parent expectations. The results showed that GMFM, PODCI, and GMFCS provide different, but strongly related information about the abilities of young children. Parents report daily function and health-related quality of life for their child using the PODCI, and their expectations for intervention outcomes may relate to a child's motor function.
Article
Clinical Neurology
Tanya Martin, Sarah McIntyre, Emma Waight, Gareth Baynam, Linda Watson, Katherine Langdon, Susan Woolfenden, Hayley Smithers-Sheedy, Juanita Sherwood, ACPR Birds Eye View Grp
Summary: The aim of this study was to provide an overview of the trends of cerebral palsy (CP) for Australian Aboriginal and Torres Strait Islander children and young adults. Data was collected from the Australian Cerebral Palsy Register (ACPR) for individuals born between 1995 and 2014. The study showed a decline in the birth prevalence of CP in this population between the mid-2000s and 2013-2014. This information can be used to advocate for funding for accessible, culturally safe, antenatal and CP services.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Sirawee Chaovalit, Karen J. Dodd, Nicholas F. Taylor
Summary: A sit-to-stand exercise programme for children with cerebral palsy classified in GMFCS levels III and IV improved self-care and mobility while reducing caregiver strain.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Clinical Neurology
Andrea Burgess, Leanne Sakzewski, Koa Whittingham, Jane Wotherspoon, Mark D. Chatfield, Robert S. Ware, Roslyn N. Boyd
Summary: This study aimed to describe the development of social function in children with cerebral palsy (CP) and its correlation with the level of communication function. The findings suggest that social function is closely related to the level of communication function in children with CP, highlighting the importance of considering individual differences based on communication function levels in assessing social function in these children.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Parag Gad, Susan Hastings, Hui Zhong, Gaurav Seth, Sachin Kandhari, V Reggie Edgerton
Summary: This study demonstrates that acute spinal neuromodulation can significantly improve postural and locomotor abilities in patients with cerebral palsy, including those who were previously unable to stand or walk independently. By observing patients' performance on a treadmill, it was found that spinal neuromodulation can improve coordination of flexor and extensor muscle pools and joint angles, thereby helping patients improve their motor function.
Article
Clinical Neurology
Johan Jarl, Ann Alriksson-Schmidt
Summary: The study found that children with cerebral palsy generally have lower academic achievement compared to the general population, with intellectual disability being a key factor. Effective communication plays a major role in influencing school outcomes, while motor function has a smaller impact. To improve academic performance, reducing communication barriers and providing appropriate support are essential.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Neurosciences
Raynald, Yanbin Li, Hao Yu, Hua Huang, Muyao Guo, Rongrong Hua, Fenjun Jiang, Kaihua Zhang, Hailong Li, Fei Wang, Lusheng Li, FuZhai Cui, Yihua An
Article
Neurosciences
Hao Yu, Lusheng Li, Raynald Liu, Bing Shu, Huizi Chen, Hua Huang, Rongrong Hua, Fenjun Jiang, Yihua An
NEUROSCIENCE LETTERS
(2016)
Article
Medicine, Research & Experimental
Xuebin Liu, Xiaojun Fu, Guanghui Dai, Xiaodong Wang, Zan Zhang, Hongbin Cheng, Pei Zheng, Yihua An
JOURNAL OF TRANSLATIONAL MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Shuiqiao Liu, Qingqing Dai, Rongrong Hua, Ting Liu, Song Han, Shujuan Li, Junfa Li
NEUROCHEMICAL RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Rongrong Hua, Song Han, Nan Zhang, Qingqing Dai, Ting Liu, Junfa Li
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Neurosciences
Bing Shu, Xiaodan Sun, Raynald Liu, Fenjun Jiang, Hao Yu, Nan Xu, Yihua An
NEUROSCIENCE LETTERS
(2019)
Article
Biochemistry & Molecular Biology
Rongrong Hua, Haiping Wei, Chunyan Liu, Zhe Shi, Yan Xing
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Cell & Tissue Engineering
Xiaojun Fu, Rongrong Hua, Xiaodong Wang, Peishen Wang, Long Yi, Aixue Yu, Jing Yang, Yan Li, Yihua An
STEM CELLS INTERNATIONAL
(2019)
Article
Neurosciences
Ying Tian, Liang Wang, Zhiqiang Qiu, Yulun Xu, Rongrong Hua
Summary: The study revealed that autophagy induced a high level of neuronal apoptosis through endoplasmic reticulum stress in neurons exposed to OGD/R. The autophagy-BiP-CHOP-caspase (8 and 9)-dependent apoptotic signaling pathway partly participated in autophagy-induced apoptosis in primary cortical neurons. This caspase-12-independent BiP-CHOP neuronal apoptosis pathway expands understanding of the neuronal apoptosis network and may provide potential intervention strategies for OGD/R injury following stroke.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Letter
Neurosciences
Rongrong Hua, Yan Xing, Jian Li, Youping Wei
Article
Anesthesiology
Rongrong Hua, Ping Li, Xiaodong Wang, Jing Yang, Pei Zheng, Xinxin Niu, Yan Li, Yihua An
