Article
Microbiology
Jessica T. Lin, Andreea Waltmann, Kara A. Moser, Zackary Park, Yu Bin Na, Ozkan Aydemir, Nicholas F. Brazeau, Panita Gosi, Patrick W. Marsh, Meredith S. Muller, Michele Spring, Somethy Sok, Jeffrey A. Bailey, David L. Saunders, Chanthap Lon, Mariusz Wojnarski
Summary: Atovaquone-proguanil remains effective against multidrug-resistant Plasmodium falciparum in Southeast Asia, but resistance is mediated by a single point mutation in cytochrome b (cytb) that can arise during treatment. Among treatment failures in a clinical trial in Cambodia, only one recrudescence harbored the cytb mutation Y268C, which appeared de novo and played a minor role in treatment failures.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Nicola Pugliese, Rossella Samarelli, Roberto Lombardi, Antonella Schiavone, Giuseppe Crescenzo, Elena Circella, Claudia Zizzadoro, Olimpia Lai, Medhat S. Saleh, Michela Prioletti, Antonio Camarda
Summary: This study describes a therapeutic protocol to treat avian malaria in snowy owls using atovaquone/proguanil. The treatment was found to be effective and safe, with no adverse effects observed during the 60-day monitoring period after the treatment. It suggests that this therapeutic regimen may be considered for other valuable and endangered avian species.
Review
Multidisciplinary Sciences
Sally Wu, Nicolette Stogios, Margaret Hahn, Janani Navagnanavel, Zahra Emami, Araba K. Chintoh, Philip Gerretsen, Ariel Graff-Guerrero, Tarek Rajji, Gary Remington, Sri Mahavir Agarwal
Summary: This systematic review and meta-analysis evaluated the effects of intranasal insulin (INI) on cognition. The results suggest that INI may have pro-cognitive benefits for individuals with Alzheimer's disease/mild cognitive impairment, but no significant effects were found in healthy individuals and other patient populations for global cognition.
Review
Environmental Sciences
Hong Zhang, Yujie Ben, Yonghe Han, Yong Zhang, Yu Li, Xinwang Chen
Summary: The meta-analysis showed a positive association between phthalate exposure and risk of DM, especially for MMP, MnBP, MiBP, MCPP, and DEHP metabolites. However, caution should be taken in interpreting the results due to the heterogeneous design of the enrolled studies.
ENVIRONMENTAL RESEARCH
(2022)
Review
Multidisciplinary Sciences
Manas Kotepui, Aongart Mahittikorn, Nsoh Godwin Anabire, Kwuntida Uthaisar Kotepui
Summary: This meta-analysis study found that blood levels of GPx were significantly decreased in malaria patients, especially in those with P. falciparum malaria. This finding provides important insights for further investigation into the role of GPx depletion in malaria pathogenesis.
SCIENTIFIC REPORTS
(2023)
Review
Multidisciplinary Sciences
Muhammad Imran Khan, Humera Qureshi, Suk Joo Bae, Aamer Ali Khattak, Muhammad Shahid Anwar, Sadique Ahmad, Fazal Hassan, Shabir Ahmad
Summary: This study conducted a systematic review and meta-analysis on malaria prevalence in Pakistan from 2006 to 2021. Out of the 315 studies collected, only 45 full-text articles were included in the final meta-analysis. The pooled malaria prevalence in Pakistan was 23.3%, with Plasmodium vivax, Plasmodium falciparum, and mixed infection rates of 79.13%, 16.29%, and 3.98%, respectively.
Review
Biochemistry & Molecular Biology
Kwuntida Uthaisar Kotepui, Aongart Mahittikorn, Polrat Wilairatana, Frederick Ramirez Masangkay, Manas Kotepui
Summary: This systematic review and meta-analysis examine the association between nitric oxide (NO) levels and malaria. The findings indicate significant disparities in NO levels based on geographic location and study time frames. However, no significant differences in mean NO levels were detected between patients and uninfected controls or between severe and non-severe malaria cases.
Review
Parasitology
Chutipong Sukkanon, Frederick Ramirez Masangkay, Wanida Mala, Kwuntida Uthaisar Kotepui, Polrat Wilairatana, Theeraphap Chareonviriyaphap, Manas Kotepui
Summary: This study conducted a systematic review and meta-analysis on the prevalence of Plasmodium infection in Anopheles mosquitoes across Thailand and found a low prevalence of Plasmodium infection. Therefore, caution must be exercised when using EIR to evaluate malaria transmission and vector control interventions in Thailand.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Joanna Tomlinson, Benjamin Ondruschka, Torsten Prietzel, Johann Zwirner, Niels Hammer
Summary: Knowledge of the innervation of the hip capsule is crucial for clinical practice. The primary nerve supply to the HC appears to be from the nerve to quadratus femoris and obturator nerve. Further investigation is needed to understand potential demographic differences in HC innervation.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Gaspare Palaia, Amelia Bellisario, Riccardo Pampena, Roberto Pippi, Umberto Romeo
Summary: PVL, a rare subtype of oral leukoplakia, has a high risk of malignant transformation, with almost 50% progressing to OSCC. Female patients, especially elderly non-smokers and non-drinkers, are at higher risk for this transformation.
Review
Infectious Diseases
Inejih El Moustapha, Mohamed Ouldabdallahi Moukah, Mohamed Salem Ould Ahmedou Salem, Khyarhoum Brahim, Sebastien Briolant, Leonardo Basco, Ali Ould Mohamed Salem Boukhary
Summary: This meta-analysis study summarizes multiple research conducted in Mauritania on the prevalence of malaria and Plasmodium species since 2000, and derives robust estimates.
Review
Nutrition & Dietetics
Felipe Mendes Delpino, Lilian Munhoz Figueiredo, Bruno Pereira Nunes
Summary: This study reviewed randomized clinical trials on the effects of melatonin supplementation in diabetes and found that melatonin can help reduce diabetes parameters such as fasting blood glucose, glycated hemoglobin, and insulin resistance compared to placebo.
CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Beatriz Isabel Garcia-Martinez, Mirna Ruiz-Ramos, Jose Pedraza-Chaverri, Edelmiro Santiago-Osorio, Victor Manuel Mendoza-Nunez
Summary: Resveratrol has the potential to improve glucose and insulin levels in patients with type 2 diabetes, with significant improvement in glucose observed at doses of 500-1000 mg/day, and improvement in insulin seen at doses lower than 500 mg/day or greater than 1000 mg/day.
Review
Biology
Jordi Ribas-Maynou, Marc Yeste, Nerea Becerra-Tomas, Kenneth Aston, Emma R. James, Albert Salas-Huetos
Summary: A systematic review and meta-analysis of studies on IVF and ICSI treatments revealed a significant negative impact of sperm DNA damage on implantation and pregnancy rates. Routine sperm DNA testing is justified to improve IVF outcomes and assist in treatment selection for couples. Further studies are needed to draw more precise conclusions, especially in the context of ICSI treatments.
BIOLOGICAL REVIEWS
(2021)
Review
Nutrition & Dietetics
Manas Kotepui, Frederick Ramirez Masangkay, Aongart Mahittikorn, Kwuntida Uthaisar Kotepui
Summary: This study used systematic review and meta-analysis to investigate the association between vitamin E levels and malaria. The results showed that vitamin E levels were significantly reduced in malaria patients, particularly in cases of severe malaria. The study highlights the potential role of vitamin E in the pathogenesis of malaria and suggests that improving vitamin E status may benefit disease outcomes.
Article
Chemistry, Medicinal
Adriana Z. Gehm, Sabrina B. Cunha, Bruce W. da Silva, Marco A. Mostardeiro, Nelci. R. Bastos, Robert A. Burrow, Miguel S. B. Caro, Ionara I. Dalcol, Ademir F. Morel
Summary: In this study, a new cyclopeptide alkaloid, condaline B, together with six known cyclopeptide alkaloids, was isolated from the rind bark of Condalia buxifolia. The structures were confirmed through spectroscopic analyses, and the absolute stereochemistry of condaline A was determined by X-ray crystal structure determination. Additionally, the compounds showed promising antimicrobial activity.
Article
Biochemistry & Molecular Biology
Janice Dahmer, Patricia Marangon, Luciana O. Adolpho, Frederico L. Reis, Graciela Maldaner, Robert A. Burrow, Marco A. Mostardeiro, Ionara I. Dalcol, Ademir F. Morel
Summary: A reinvestigation of the chemical constituents of the stem barks of Scutia buxifolia resulted in the isolation of several new alkaloids. The structures and stereochemistry of these compounds were determined using various analytical techniques. Additionally, the compounds showed promising antibacterial activity.
Article
Infectious Diseases
Odilon Nouatin, Javier Ibanez, Rolf Fendel, Ulysse A. Ngoa, Freia-Raphaella Lorenz, Jean-Claude Dejon-Agobe, Jean Ronald Edoa, Judith Fluegge, Sina Brueckner, Meral Esen, Michael Theisen, Stephen L. Hoffman, Kabirou Moutairou, Adrian J. F. Luty, Bertrand Lell, Peter G. Kremsner, Ayola A. Adegnika, Benjamin Mordmueller
Summary: In a vaccine trial investigating the malaria vaccine candidate GMZ2, it was found that the GMZ2-specific antibody response increased after vaccination but was not correlated to protection. However, antibody responses to several Plasmodium falciparum antigens and the broadness of malaria-specific antibody response were significantly higher in protected study participants.
Editorial Material
Infectious Diseases
Sanjeev Krishna, Peter G. Kremsner
Summary: This commentary raises questions about the methodology of Obonyo et al.'s malaria treatment study, particularly regarding the chosen time points for measuring treatment outcomes.
Article
Infectious Diseases
Jabar Babatunde Pacome Achimi Agbo Abdul, Bayode Romeo Adegbite, Micheska Epola Dibamba Ndanga, Jean Ronald Edoa, Rhett Chester Mevyann, Guy Rogue Arnault Ibinda Mfoumbi, Tshisekedi Jean de Dieu, Jocelyn Mahoumbou, Christopher Mebiame Biyogho, Sankarganesh Jeyaraj, Stefan Niemann, Bertrand Lell, Peter Gottfried Kremsner, Abraham Sunday Alabi, Ayola Akim Adegnika, Martin Peter Grobusch
Summary: The increasing incidence of MDR-TB infection in Gabon is alarming, especially among individuals aged 25-35. There is a need for improvement in case finding and contact tracing strategies for treatment-naive MDR-TB patients.
Article
Medicine, Research & Experimental
Oriol Mitja, Gilmar Reis, David R. Boulware, Adam M. Spivak, Ammar Sarwar, Christine Johnston, Brandon Webb, Michael D. Hill, Davey Smith, Peter Kremsner, Marla Curran, David Carter, Jim Alexander, Marc Corbacho, Todd C. Lee, Katherine Huppler Hullsiek, Emily G. McDonald, Rachel Hess, Michael Hughes, Jared M. Baeten, Ilan Schwartz, Luanne Metz, Lawrence Richer, Kara W. Chew, Eric Daar, David Wohl, Michael Dunne
Summary: This study conducted a pooled analysis of individual participant data from 11 randomized controlled trials to evaluate the efficacy of hydroxychloroquine (HCQ) in outpatients with mild COVID-19. The results suggest that HCQ does not show significant effects on viral clearance and hospitalization rate, and therefore, the use of HCQ in mild COVID-19 outpatients should be discontinued to reduce the risk of disease progression.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Oncology
David K. Lau, Maria Aresu, Timothy Planche, Amina Tran, Retchel Lazaro-Alcausi, Julie Duncan, Shannon Kidd, Susan Cromarty, Ruwaida Begum, Isma Rana, Su Li, Ali Abdulnabi Mohamed, Irene Monahan, David J. Clark, Nicholas Eckersley, Henry M. Staines, Elisabetta Groppelli, Sanjeev Krishna, Martin Mayora-Neto, Nigel Temperton, Charlotte Fribbens, David Watkins, Naureen Starling, Ian Chau, David Cunningham, Sheela Rao
Summary: The study evaluated the prevalence of neutralizing antibodies in 152 gastrointestinal cancer patients receiving chemotherapy after SARS-CoV-2 vaccination, finding that despite the immunosuppressive effects of chemotherapy, two doses of vaccines can still induce a protective immune response in patients undergoing treatment.
Review
Medicine, General & Internal
Yolanda Augustin, Henry M. Staines, Thirumalaisamy P. Velavan, Adeeba Kamarulzaman, Peter G. Kremsner, Sanjeev Krishna
Summary: The COVID-19 pandemic has led to global research on drug repurposing, focusing on antiviral therapies, anti-inflammatory agents, antithrombotic agents, and immune modulators. Corticosteroids and immunomodulators targeting IL-6 receptors have been shown to be effective in improving clinical outcomes. Other drugs under investigation include antidiabetic, antimalarial, tyrosine kinase inhibitors, antiviral, antiparasitic, and antidepressant drugs.
BRITISH MEDICAL BULLETIN
(2023)
Article
Infectious Diseases
Elke Wynberg, Robert J. Commons, Georgina Humphreys, Hazel Ashurst, Rebekah Burrow, George O. Adjei, Martin Adjuik, Nicholas M. Anstey, Anup Anvikar, Kevin J. Baird, Bridget E. Barber, Hubert Barennes, Elisabeth Baudin, David J. Bell, Delia Bethell, Tran Quang Binh, Isabelle Borghini, Cindy S. Chu, Andre Daher, Umberto D'Alessandro, Debashish Das, Timothy Me Davis, Peter J. de Vries, Abdoulaye A. Djimde, Arjen M. Dondorp, Grant Dorsey, Jean-Francois F. Faucher, Carole Fogg, Oumar Gaye, Matthew Grigg, Christoph Hatz, Piet A. Kager, Marcus Lacerda, Moses Laman, Andreas Martensson, Herve Ignace Eby Menan, Wuelton M. Monteiro, Brioni R. Moore, Francois Nosten, Bernhards Ogutu, Lyda Osorio, Louis K. Penali, Dhelio B. Pereira, Awab G. Rahim, Michael Ramharter, Issaka Sagara, Birgit Schramm, Lorenz Seidlein, Andre M. Siqueira, Sodiomon B. Sirima, Peter Starzengruber, Inge Sutanto, Walter R. Taylor, Offianan A. Toure, Jurg Utzinger, Innocent Valea, Giovanni Valentini, Nicholas J. White, Timothy William, Charles J. Woodrow, Caitlin L. Richmond, Philippe J. Guerin, Ric N. Price, Kasia Stepniewska
Summary: This study describes the variability in white blood cell count during acute uncomplicated malaria and estimates the impact of using an assumed value of white blood cell count on estimates of parasite density and clearance.
Article
Virology
Gedeon Prince Manouana, Paul Alvyn Nguema-Moure, Alexandru Tomazatos, Moustapha Nzamba Maloum, C. -Thomas Bock, Peter G. G. Kremsner, Thirumalaisamy P. P. Velavan, Akim Ayola Adegnika, Sandra Niendorf
Summary: This study aimed to evaluate the performance of the rapid rotavirus test compared to the one-step RT-qPCR method. The results showed that the rapid test had high sensitivity and was suitable for detecting rotavirus A in patients with gastroenteritis, especially in low-income countries.
Article
Multidisciplinary Sciences
Jessica Caffry, Matthew Selby, Katie Barr, George Morgan, David McGurk, Philip Scully, Catherine Park, Anna-Maria Caridis, Emily Southworth, Jack Morrison, David J. Clark, Benedict M. O. Davies, Nicholas M. Eckersley, Elisabetta Groppelli, Daniela E. Kirwan, Irene Monahan, Yolanda Augustin, Colin Toombs, Tim Planche, Henry M. Staines, Sanjeev Krishna
Summary: Accurate and rapid point-of-care diagnostics are crucial for controlling the COVID-19 pandemic. A preliminary evaluation of the QuantuMDx Q-POC SARS-CoV-2 RT-PCR assay showed that it is a sensitive, specific, and rapid diagnostic tool.
SCIENTIFIC REPORTS
(2023)
Letter
Pediatrics
Constanze Heinzel, Yudi T. Pinilla, Ayla Binder, Peter G. Kremsner, Jana Held, Rolf Fendel, Andrea Kreidenweiss
Article
Microbiology
Tina Krueger, Moses Ikegbunam, Abel Lissom, Thaisa Lucas Sandri, Jacques Dollon Mbama Ntabi, Jean Claude Djontu, Marcel Tapsou Baina, Romeo Aime Laclong Lontchi, Moustapha Maloum, Givina Zang Ella, Romuald Agonhossou, Romaric Akoton, Luc Djogbenou, Steffen Borrmann, Jana Held, Francine Ntoumi, Ayola Akim Adegnika, Peter Gottfried Kremsner, Andrea Kreidenweiss
Summary: The frequency of pfhrp2 and pfhrp3 deleted strains in Central and West Africa was assessed and found to be low, indicating a low risk of false-negative results in HRP2-based rapid diagnostic tests. However, continuous monitoring is crucial due to the potential for rapid changes in this scenario to ensure the suitability of RDTs for malaria diagnostics.
Letter
Pediatrics
Constanze Heinzel, Yudi T. Pinilla, Ayla Binder, Peter G. Kremsner, Jana Held, Rolf Fendel, Andrea Kreidenweiss
Summary: This cross-sectional study examines IgG antibody levels in children and adolescents in Germany after SARS-CoV-2 infection.
Article
Public, Environmental & Occupational Health
Hamada S. Badr, Josh M. Colston, Nhat-Lan H. Nguyen, Yen Ting Chen, Eleanor Burnett, Syed Asad Ali, Ajit Rayamajhi, Syed M. Satter, Nguyen Van Trang, Daniel Eibach, Ralf Krumkamp, Juergen May, Ayola Akim Adegnika, Gedeon Prince Manouana, Peter Gottfried Kremsner, Roma Chilengi, Luiza Hatyoka, Amanda K. Debes, Jerome Ateudjieu, Abu S. G. Faruque, M. Jahangir Hossain, Suman Kanungo, Karen L. Kotloff, Inacio Mandomando, M. Imran Nisar, Richard Omore, Samba O. Sow, Anita K. M. Zaidi, Nathalie Lambrecht, Bright Adu, Nicola Page, James A. Platts-Mills, Cesar Mavacala Freitas, Tuula Pelkonen, Per Ashorn, Kenneth Maleta, Tahmeed Ahmed, Pascal Bessong, Zulfiqar A. Bhutta, Carl Mason, Estomih Mduma, Maribel P. Olortegui, Pablo Penataro Yori, Aldo A. M. Lima, Gagandeep Kang, Jean Humphrey, Robert Ntozini, Andrew J. Prendergast, Kazuhisa Okada, Warawan Wongboot, Nina Langeland, Sabrina J. Moyo, James Gaensbauer, Mario Melgar, Matthew Freeman, Anna N. Chard, Vonethalom Thongpaseuth, Eric Houpt, Benjamin F. Zaitchik, Margaret N. Kosek
Summary: This study aimed to model the spatiotemporal variation in paediatric Shigella infection and predict its prevalence across low-income and middle-income countries. The findings revealed the association between Shigella and climatological factors, with sub-Saharan Africa being a high-risk region for transmission. These findings can guide prioritization of populations for future vaccine trials and campaigns.
LANCET GLOBAL HEALTH
(2023)