Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response

Population Pharmacokinetics of Colistin Methanesulfonate and Colistin in Critically Ill Patients with Acute Renal Failure Requiring Intermittent Hemodialysis

(2016) M. Jacobs et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells

(2016) Chongshan Dai et al.   FOOD AND CHEMICAL TOXICOLOGY

Baicalein protects C6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the Nrf2 signaling pathway

(2016) EUN-OK CHOI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice

(2016) Bidya Dhar Sahu et al.   LIFE SCIENCES

Polymyxin B Nephrotoxicity: From Organ to Cell Damage

(2016) Maria de Fátima Fernandes Vattimo et al.   PLoS One

Significant Accumulation of Polymyxin in Single Renal Tubular Cells: A Medicinal Chemistry and Triple Correlative Microscopy Approach

(2015) Mohammad A. K. Azad et al.   ANALYTICAL CHEMISTRY

Major Pathways of Polymyxin-Induced Apoptosis in Rat Kidney Proximal Tubular Cells

(2015) Mohammad A. K. Azad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Baicalein protects against polymicrobial sepsis-induced liver injury via inhibition of inflammation and apoptosis in mice

(2015) Anding Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The effects of baicalein and baicalin on mitochondrial function and dynamics: A review

(2015) Marcos Roberto de Oliveira et al.   PHARMACOLOGICAL RESEARCH

High dose intravenous colistin methanesulfonate therapy is associated with high rates of nephrotoxicity; a prospective cohort study from Saudi Arabia

(2015) Ali S Omrani et al.   Annals of Clinical Microbiology and Antimicrobials

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

(2015) Kade D. Roberts et al.   ACS Infectious Diseases

Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways

(2015) Bidya Dhar Sahu et al.   PLoS One

Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

(2014) Chongshan Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Colistin-Induced Nephrotoxicity in Mice Involves the Mitochondrial, Death Receptor, and Endoplasmic Reticulum Pathways

(2014) Chongshan Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese?

(2014) R. L. Nation et al.   CLINICAL INFECTIOUS DISEASES

Imaging the distribution of polymyxins in the kidney

(2014) B. Yun et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects

(2014) Min Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Interaction between systemic inflammation and renal tubular epithelial cells

(2014) Vincenzo Cantaluppi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

How Does Colistin-Induced Nephropathy Develop and Can It Be Treated?

(2013) Gulsum Ozkan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells

(2013) Mohammad A. K. Azad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics

(2013) Tony Velkov et al.   Future Microbiology

Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production

(2013) Zhilin Qi et al.   INFLAMMATION RESEARCH

Cell cycle arrest in a model of colistin nephrotoxicity

(2013) Michael T. Eadon et al.   PHYSIOLOGICAL GENOMICS

Role of Heme Oxygenase-1 in Polymyxin B-Induced Nephrotoxicity in Rats

(2012) Cassiane Dezoti Fonseca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Baicalein protects Human melanocytes from H2O2-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway

(2012) Bangmin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Baicalein Protects against 6-OHDA-Induced Neurotoxicity through Activation of Keap1/Nrf2/HO-1 and Involving PKCα and PI3K/AKT Signaling Pathways

(2012) Zaijun Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal

(2011) Jianjun Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Baicalein loaded in tocol nanostructured lipid carriers (tocol NLCs) for enhanced stability and brain targeting

(2011) Ming-Jun Tsai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics

(2011) J. M. Yousef et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in d-GalN/LPS induced acute liver failure in murine models

(2010) Yan-Ling Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Iron-binding and anti-Fenton properties of baicalein and baicalin

(2008) Carlos A. Perez et al.   JOURNAL OF INORGANIC BIOCHEMISTRY