Article
Microbiology
Mona Shaban E. M. Badawy, Walid F. Elkhatib, Rania I. Shebl
Summary: This study evaluated the anti-biofilm potentials of various antibiotics alone and in combination against biofilm-forming carbapenem-resistant Pseudomonas aeruginosa (CRPA). The results showed that colistin exhibited the strongest anti-biofilm activity, followed by gentamicin and meropenem, while ceftazidime had the least activity. Combination therapy showed synergistic effects. The simulated pharmacodynamic modeling confirmed the synergistic anti-biofilm activity observed in vitro.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Infectious Diseases
Jessica Howard-Anderson, Michelle Davis, Alexander M. Page, Chris W. Bower, Gillian Smith, Jesse T. Jacob, Dan Andersson, David S. Weiss, Sarah W. Satola
Summary: This study investigated the prevalence of colistin heteroresistance in carbapenem-resistant Pseudomonas aeruginosa (CRPA) and its association with clinical outcomes. The results showed that colistin heteroresistance was present in up to 26% of CRPA patients, but it did not have a significant impact on 90-day mortality.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Jae-Min Park, Kyung-Sook Yang, You-Seung Chung, Ki-Byung Lee, Jeong-Yeon Kim, Sun-Bean Kim, Jang-Wook Sohn, Young-Kyung Yoon
Summary: This study compared the clinical outcomes and safety of meropenem-colistin versus meropenem-tigecycline in treating adult patients with carbapenem-resistant Acinetobacter baumannii (CRAB) pneumonia. The results suggest that meropenem-tigecycline combination therapy may be a valuable treatment option, while episodes of nephrotoxicity were significantly more common in the meropenem-colistin group.
Article
Infectious Diseases
Jacinda C. Abdul-Mutakabbir, Juwon Yim, Logan Nguyen, Philip T. Maassen, Kyle Stamper, Zain Shiekh, Razieh Kebriaei, Ryan K. Shields, Mariana Castanheira, Keith S. Kaye, Michael J. Rybak
Summary: The study explored the potential utility of antibiotic combinations for carbapenem-resistant Acinetobacter baumannii isolates, identifying synergistic and bactericidal effects in certain combination therapies. Results suggest that certain antibiotic combinations can restore efficacy against resistant strains, offering new treatment options for difficult-to-treat infections caused by Acinetobacter baumannii.
Article
Infectious Diseases
Rebeca Carvalho Lacerda Garcia, Rodrigo Douglas Rodrigues, Ester Carvalho Lacerda Garcia, Maria Helena Rigatto
Summary: This study evaluated the impact of polymyxin B versus colistin on mortality and nephrotoxicity in carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa bloodstream infections. The results showed that treatment with polymyxin B or colistin did not affect the 30-day mortality in patients with these bacterial infections.
Article
Microbiology
Yuhang Wang, Chunsun Li, Jin Wang, Nan Bai, Huan Zhang, Yulong Chi, Yun Cai
Summary: In this study, the in vitro and in vivo efficacy of colistin-based combinations against Pseudomonas aeruginosa (PA) biofilm were evaluated. The results showed that colistin combined with levofloxacin or amikacin could effectively eradicate the biofilm. This study provided a new treatment regimen for PA biofilm infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Eva Benavent, Marta Ulldemolins, Cristina El Haj, Raul Rigo-Bonnin, Heidi Yu, Lynn Wang, Hasini Wickremasinghe, Javier Ariza, Oscar Murillo
Summary: This study aimed to analyze the PK/PD indices of meropenem predicting anti-biofilm efficacy against meropenem-susceptible and meropenem-resistant strains of Pseudomonas aeruginosa. The results showed that f%T >MIC was the PK/PD index that best correlated with the anti-biofilm efficacy of meropenem. Using the extended infusion regimen of meropenem can better recover bactericidal activity in monotherapy, including activity against meropenem-resistant P. aeruginosa.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Ecology
Thomas James O'Brien, Wendy Figueroa, Martin Welch
Summary: The presence of diverse polymicrobial communities in the airways of individuals with cystic fibrosis can hinder the effectiveness of antibiotic treatment. A study showed that growth in a polymicrobial environment protects the target microorganism from the effects of specific antimicrobial agents. This decreased efficacy is found to have both physiological and genetic components.
Article
Engineering, Biomedical
Mohammad Yousef Memar, Mina Yekani, Hadi Ghanbari, Edris Nabizadeh, Sepideh Zununi Vahed, Solmaz Maleki Dizaj, Simin Sharifi
Summary: The study revealed that meropenem-loaded mesoporous silica nanoparticles exhibit significant antimicrobial and antibiofilm effects against carbapenem resistant Pseudomonas aeruginosa, with low cytotoxicity in vitro. This prepared system could be a suitable option for delivering carbapenem for further evaluation in vivo assays.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Infectious Diseases
Tomasz Bogiel, Malgorzata Prazynska, Joanna Kwiecinska-Pirog, Agnieszka Mikucka, Eugenia Gospodarek-Komkowska
Summary: The study compared the frequency of selected enzymatic virulence factor genes among non-duplicated carbapenem-resistant P. aeruginosa isolates, finding a higher prevalence of alkaline protease gene and a 37.4% detection rate for neuraminidase-1 gene. Significant differences in the prevalence of lasB and nan1 were observed between MBL-positive and MBL-negative strains.
Article
Microbiology
Luisa Sorli, Sonia Luque, Jian Li, Adela Benitez-Cano, Xenia Fernandez, Nuria Prim, Victoria Vega, Joan Gomez-Junyent, Inmaculada Lopez-Montesinos, Silvia Gomez-Zorrilla, M. Milagro Montero, Santiago Grau, Juan Pablo Horcajada
Summary: This study investigated the relationship between colistin plasma concentrations and clinical outcomes in patients with hospital-acquired pneumonia caused by extensively drug-resistant Pseudomonas aeruginosa. The findings showed that higher colistin exposure did not improve clinical outcomes.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Anthony Sophonsri, Corey Kelsom, Mimi Lou, Paul Nieberg, Annie Wong-Beringer
Summary: The study found that patients coinfected with CRKP and another carbapenem-resistant pathogen have more significant morbidity and require longer hospital stays compared to those with CRKP monoinfection. Empiric therapy targeting both CRKP and carbapenem-resistant Pseudomonas aeruginosa may be beneficial for at-risk patients with pneumonia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Wentao Ni, Yifan Wang, Xinqian Ma, Yukun He, Jin Zhao, Jie Guan, Yanjun Li, Zhancheng Gao
Summary: The study found that cefiderocol combined with tigecycline can effectively combat carbapenem-resistant Acinetobacter baumannii, showing synergistic effects regardless of susceptibility or resistance to cefiderocol.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Microbiology
Lingbo Wang, Ying Zhang, Yishuai Lin, Jianming Cao, Chunyan Xu, Liqiong Chen, Yaran Wang, Yao Sun, Xiangkuo Zheng, Yong Liu, Tieli Zhou
Summary: P. aeruginosa is a widespread bacterium associated with life-threatening infections. Improper use of antibiotics has led to the emergence of multidrug-resistant strains, including colistin-resistant strains. This study demonstrates that colistin/resveratrol combination therapy has a strong synergistic effect in eradicating colistin-resistant P. aeruginosa strains and their biofilms.
MICROBIOLOGY SPECTRUM
(2023)
Article
Environmental Sciences
Katja Kehl, Anja Schallenberg, Christiane Szekat, Cathrin Albert, Esther Sib, Martin Exner, Nicole Zacharias, Christiane Schreiber, Marjio Parcina, Gabriele Bierbaum
Summary: The study identified carbapenem-resistant bacteria in the wastewater of a large hospital, with high-risk clones potentially being directly disseminated into the environment. Two possible transmission pathways were identified, highlighting the need for remediation measures at both ends of the wastewater system.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)