Article
Agriculture, Multidisciplinary
Zhibing Wu, Jin Shi, Jixiang Chen, Deyu Hu, Baoan Song
Summary: Novel 1,3,4-thiadiazole derivatives containing an amide moiety were designed and synthesized to discover new antibacterial agents, with compound 30 showing superior protective and curative activities against rice bacterial diseases compared to thiodiazole copper.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Jun-Da Qi, Yu-Qing Meng, Jingxin Sun, Wan-Xin Li, Hou-Xiang Zhai, Changhao Zhang, Jishan Quan, Cheng-Hua Jin
Summary: Four novel pyrazole derivatives were synthesized and their antibacterial and antifungal activities were evaluated. Some of these compounds exhibited strong antifungal activity and high selectivity without cytotoxicity against human cells.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Multidisciplinary
Yafei Shu, Meihang Chen, Daowang Lu, Zengyan Zhou, Jianhong Yu, Xiaoling Hu, Jiaqin Yang, Aiqin Li, Jianglong Liu, Hairong Luo
Summary: A series of novel galactoside derivatives containing 1,3,4-thiadiazole moiety were synthesized and tested for their antifungal and antibacterial activities. The results showed that these synthesized compounds exhibited good antifungal activities and certain antibacterial activities.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ju Peng, Yong Zhang, Xing Liu, Yue Zou, Hongyi Song, Sheng Wang, Qingfeng Cai, Jixiang Chen, Deyu Hu
Summary: Rice bacterial diseases pose a serious threat to the global rice industry, and chemical control remains an effective means to combat them. The study involved the design and synthesis of 42 resveratrol derivatives as potential antibacterial agents. Compound B1 exhibited excellent antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc), with EC50 values of 4.76 and 8.85 mg/L, respectively. Additionally, compound B1 was found to induce changes in bacterial cell surface morphology and hinder the normal growth of bacteria.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Sikai Wu, Jing Shi, Jixiang Chen, Deyu Hu, Liansheng Zang, Baoan Song
Summary: A series of novel 6-sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized. The established CoMFA models were used to analyze and design compounds with higher activities, revealing their mechanisms of action in disease resistance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Tingting Liu, Feng Peng, Xiao Cao, Fang Liu, Qifan Wang, Liwei Liu, Wei Xue
Summary: A series of myricetin derivatives containing a quinazolinone moiety were designed and synthesized, and their antibacterial and antiviral activities were evaluated. The results showed that some target compounds exhibited good antibacterial activities in vitro and antiviral activities in vivo. This study reveals the potential of myricetin derivatives as antibacterial and antiviral agents.
Article
Chemistry, Multidisciplinary
Pei Li, Cong Chen, Rongxi Zhu, Guixia Yang, Min Xu, Guanghua Wan, Xiang Wang
Summary: In this study, novel derivatives of botanical active components were synthesized and evaluated for their antibacterial activities. One compound showed excellent inhibitory activity against Xanthomonas axonopodis pv. citri and Xanthomonas oryzae pv. oryzicola.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Honglan Mou, Jing Shi, Jixiang Chen, Deyu Hu
Summary: The newly designed butenolide derivatives exhibited good antibacterial activities, with compound 19 showing superior in vitro antibacterial activity against Xanthomonas oryzae pv. oryzae and excellent curative and protective activities against bacterial leaf blight under greenhouse conditions compared to bismerthiazol. Additionally, compound 19 was found to induce changes in the cell surface morphology of Xoo and enhance rice defense enzymes, with its protective activity related to the improvement of defense-related enzyme activities and upregulation of proteins involved in oxidative phosphorylation.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Upare Abhay Atmaram, Selvaraj Mohana Roopan
Summary: This review focuses on the pharmacological properties and structural modifications of the 5-membered heterocycles oxadiazole and thiadiazole, with a particular emphasis on the anti-tubercular and anticancer activities. These heterocycles exhibit important bioisosterism and can serve as replacements in drug design.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lu Yu, Jiyan Chi, Lingling Xiao, Jie Li, Zhangfei Tang, Shuming Tan, Pei Li
Summary: A series of novel thiochromanone derivatives designed and synthesized showed good antibacterial activities against various Xanthomonas strains, but lower antifungal activities compared to Carbendazim.
Article
Chemistry, Multidisciplinary
Afaf Y. Khormi, Thoraya A. Farghaly, Abrar Bayazeed, Youssef O. Al-Ghamdi, Hanan Gaber Abdulwahab, Mohamed R. Shaaban
Summary: Novel thiazole derivatives were synthesized and found to possess significant inhibitory activity against B-RAFV600E kinase, with high selectivity towards B-RAF wild type. Compounds 7b and 13a exhibited excellent inhibitory activity and showed strong anticancer activity against mutated melanoma cells.
Article
Agriculture, Multidisciplinary
Qing Zhou, Yuanxiang Zhou, Yunying Zhu, Chenyu Gong, Yongjun Wu, Wei Xue
Summary: Novel 1,4-pentadien-3-one derivatives with a sulfonamide moiety were synthesized and their activities against fungi, bacteria, and viruses were tested. These compounds exhibited potent antibacterial and antifungal effects, and some showed promising antiviral activity. The study suggests that active splicing can enhance the biological activity of natural compounds, providing potential for the development of novel pesticides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jiansong An, Wenjun Lan, Qiang Fei, Pei Li, Wenneng Wu
Summary: This study reports the antifungal and antibacterial activities of novel benzoylurea derivatives containing a pyrimidine moiety. Some of the compounds exhibited moderate to good in vitro antifungal activities against various fungi, and the interaction with succinate dehydrogenase was found to contribute to their mechanism of action.
Article
Chemistry, Medicinal
Jiahui Zhu, Guosheng Teng, Dongfeng Li, Ruibin Hou, Yan Xia
Summary: Increased bacterial resistance to antibiotics poses a major threat to human health, highlighting the importance of developing novel antibiotic drugs. The designed Schiff base thiosemicarbazone derivatives showed promising inhibitory effects against bacteria, providing valuable data for the development of improved antibacterial agents in the future.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Hongde Li, Shang Wu, Xiong Yang, Hongfu He, Zengxue Wu, Baoan Song, Runjiang Song
Summary: The study revealed a series of novel indole derivatives with antibacterial activity and identified a new compound with higher activity, which could potentially be utilized in the modern pesticide industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)