期刊
JOURNAL OF ANIMAL SCIENCE
卷 95, 期 10, 页码 4239-4250出版社
OXFORD UNIV PRESS INC
DOI: 10.2527/jas2016.1297
关键词
Large White pigs; long noncoding RNA; Mashen pigs; RNA sequencing; skeletal muscle
资金
- Foundation of Science and Technology Innovation Team of Shanxi Province [201605D131045-24]
- Shanxi Science and Technology Committee [20130311026-1, 20140311020-5]
- Foundation of Science and Technology Achievements Transformation Projects in Shanxi Province [SXNKTG09]
- Foundation of Higher School Science and Technology Innovation in Shanxi Province [2014129]
Long noncoding RNA (lncRNA) has been increasingly implicated in the regulation of muscle development. Large White pigs have a higher muscle growth rate than do Mashen pigs. In the present study, the lncRNA expression profiles in skeletal muscle of these 2 pig breeds were compared at 1, 90, and 180 d of age using RNA sequencing. We obtained 2,718 million clean reads and identified a total of 5,153 novel lncRNA. We found 1,407 differentially expressed lncRNA that showed consistent expression patterns between the 2 breeds at all the 3 sampling points. Ten lncRNA were randomly selected, and their expression was validated using Real-time Quantitative PCR. In summary, this study identifies a number of lncRNA that correlate with muscle growth. The regulation and function of these lncRNA in muscle growth and development need to be further explored.
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