Article
Biochemistry & Molecular Biology
Yu Kitaoka
Summary: Nrf2 is believed to play a crucial role in protecting cells against oxidative stress and is also involved in energy metabolism. This review briefly discusses the role of Nrf2 in skeletal muscle metabolism from the perspective of exercise physiology.
Article
Physiology
Jingqing Chen, Xihong Zhou, Hai Jia, Zhenlong Wu
Summary: Serine administration can alleviate doxorubicin-induced oxidative damage in skeletal muscle of mice by enhancing NRF2/CAR signaling pathway.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ines Marques-Aleixo, Jorge Beleza, Arnaldina Sampaio, Jelena Stevanovic, Pedro Coxito, Ines Goncalves, Antonio Ascensao, Jose Magalhaes
Summary: The prevalence of age-related neurodegenerative diseases (NDDs) is increasing with the global rise in life expectancy, impacting health, social systems, and economies significantly. While pharmaceutical therapies for NDDs have limited benefits, regular physical exercise is seen as a nonpharmacological alternative that can modulate brain structure and function for a healthier neurological phenotype.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Geriatrics & Gerontology
Hyunjung Lee, Tae Youl Ha, Chang Hwa Jung, Farida Sukma Nirmala, So-Young Park, Yang Hoon Huh, Jiyun Ahn
Summary: The study revealed that acute insulin resistance coincides with mitochondrial dysfunction in skeletal muscle, leading to impaired mitochondrial function and the development of acute insulin resistance. Improving mitochondrial function has significant potential in treating acute insulin resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Endocrinology & Metabolism
Stephen T. Decker, Oh-Sung Kwon, Jia Zhao, John R. Hoidal, Thomas Heuckstadt, Russell S. Richardson, Karl A. Sanders, Gwenael Layec
Summary: This study found that sedentary mice exposed to cigarette smoke for 8 months showed preserved mitochondrial respiratory capacity in skeletal muscle, but also increased risk of chronic oxidative stress.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Neurosciences
Yifan Chen, Tianzheng Yu, Patricia Deuster
Summary: The hypothalamus plays a crucial role in regulating energy and temperature homeostasis and its response to heat stress involving mitochondrial dysfunction and apoptosis is explored in this study. Heat exposure induces mitochondrial fission, damage, apoptosis, and mitophagy in the hypothalamus, but pretreatment with the antioxidant AST can protect against these effects. Overall, heat stress-induced hypothalamic apoptosis is associated with altered mitochondrial dynamics favoring fission and mitophagy, which can be mitigated by AST through preserving redox homeostasis and mitochondrial integrity.
Article
Biochemistry & Molecular Biology
Cristina Gatto, Angela Di Porzio, Raffaella Crescenzo, Valentina Barrella, Susanna Iossa, Arianna Mazzoli
Summary: The short-term consumption of a high-fructose diet has a significant impact on skeletal muscle metabolism, with more pronounced effects in young individuals than in adults. The study found that young rats showed marked mitochondrial dysfunction and increased oxidative damage, leading to a decrease in insulin sensitivity. These findings highlight the importance of reducing fructose intake, especially in young people, to maintain metabolic health.
Article
Biochemistry & Molecular Biology
Erik D. Marchant, Jamie P. Kaluhiokalani, Taysom E. Wallace, Mohadeseh Ahmadi, Abigail Dorff, Jessica J. Linde, Olivia K. Leach, Robert D. Hyldahl, Jayson R. Gifford, Chad R. Hancock
Summary: This study compared the effects of 6 weeks of localized heat therapy and single-leg interval training on human skeletal muscle mitochondria. The results showed that both heat therapy and exercise training significantly improved mitochondrial respiratory capacity, but heat therapy did not improve fatty acid oxidation capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Hongyang Xu, Rojina Ranjit, Arlan Richardson, Holly Van Remmen
Summary: This study demonstrates that scavenging mitochondrial hydrogen peroxide efficiently prevents mitochondrial dysfunction and NMJ disruption associated with denervation-induced muscle atrophy and weakness. These findings highlight mitochondrial H2O2 as a crucial effector of NMJ alterations leading to sarcopenia-related phenotypes.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Sylwia M. Kacprzak, Olivier Van Aken
Summary: Mitochondria play vital roles in plant metabolism and stress responses. Quality control systems, including mitophagy, are important for maintaining a healthy mitochondrial pool. The 'Friendly Mitochondria' protein (FMT) has been identified as a crucial player in mitophagy during dark-induced senescence in Arabidopsis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Tiejian Nie, Kai Tao, Lin Zhu, Lu Huang, Sijun Hu, Ruixin Yang, Pingyi Xu, Zixu Mao, Qian Yang
Summary: This study demonstrates the critical role of chaperone-mediated autophagy (CMA) in maintaining proper mitochondria dynamics. Loss of this regulatory control may occur in Parkinson's disease (PD), leading to impaired mitochondria function. Increasing CMA activity promotes MARCHF5 turnover, reduces mitochondria fragmentation, and alleviates mitochondrial dysfunction under oxidative stress.
Article
Cell Biology
Wojciech Trybus, Teodora Krol, Ewa Trybus, Anna Stachurska
Summary: Physcion exerts antitumor effects by inducing oxidative stress, autophagy, and apoptosis in HeLa cells, resulting in decreased cell viability, G0/G1 phase cell cycle arrest, and activation of the lysosomal system.
Review
Cell Biology
Yuvraj Anandrao Jagtap, Prashant Kumar, Sumit Kinger, Ankur Rakesh Dubey, Akash Choudhary, Ravi Kumar Gutti, Sarika Singh, Hem Chandra Jha, Krishna Mohan Poluri, Amit Mishra
Summary: Disturbance in mitochondrial functions is a defining characteristic of neurodegenerative diseases, such as Parkinson's, ALS, and Alzheimer's. Misfolded proteins play a role in the impairment of mitochondrial pathways, exacerbating disease progression. However, the impact of mitochondrial dysfunction on other organelles and cellular processes remains understudied. Investigating the interplay between mitochondria and neurodegeneration can provide valuable insights for targeted therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Jun Ding, Jian Jin, Yan Na Lei, Sheng Cui, Hui Ying Li, Hai Lan Zheng, Shang Guo Piao, Yu Ji Jiang, Mei Ying Xuan, Ji Zhe Jin, Ying Shun Jin, Jung Pyo Lee, Byung Ha Chung, Bum Soon Choi, Chul Woo Yang, Can Li
Summary: The study demonstrated that PK treatment protects against chronic TAC-induced renal injury by inhibiting PI3K/AKT signaling. PK improved renal function and histopathology, while also downregulating proinflammatory and profibrotic cytokine expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Antonio Michelucci, Chen Liang, Feliciano Protasi, Robert T. Dirksen
Summary: This review highlights the importance of Ca2+ signaling and ATP generation in skeletal muscle contraction and outlines the role of impaired Ca2+ handling, dysfunctional ROS/RNS production, and structural/functional alterations in CRUs and mitochondria in various muscle disorders. Understanding these processes is crucial for identifying potential therapeutic targets to prevent or reverse muscle dysfunction in aging and disease.
Article
Nutrition & Dietetics
Wei Zhang, Kellie A. Kroscher, Robert L. Murray, Rachel Gagliardi, Carly Guiltinan, Robert P. Rhoads, Chad H. Stahl
JOURNAL OF NUTRITION
(2020)
Article
Agriculture, Dairy & Animal Science
Morgan E. Biggs, Kellie A. Kroscher, Lidan D. Zhao, Zhenhe Zhang, Emma H. Wall, David M. Bravo, Robert P. Rhoads
JOURNAL OF ANIMAL SCIENCE
(2020)
Review
Reproductive Biology
E. J. Mayorga, J. W. Ross, A. F. Keating, R. P. Rhoads, L. H. Baumgard
Article
Agriculture, Dairy & Animal Science
E. A. Horst, L. M. van den Brink, E. J. Mayorga, M. Al-Qaisi, S. Rodriguez-Jimenez, B. M. Goetz, M. A. Abeyta, S. K. Kvidera, L. S. Caixeta, R. P. Rhoads, L. H. Baumgard
JOURNAL OF DAIRY SCIENCE
(2020)
Article
Nutrition & Dietetics
Dane W. Fausnacht, Ryan P. McMillan, Nabil E. Boutagy, Ryan A. Lupi, Mordecai M. Harvey, Brenda M. Davy, Kevin P. Davy, Robert P. Rhoads, Matthew W. Hulver
Article
Agriculture, Dairy & Animal Science
Dane W. Fausnacht, Kellie A. Kroscher, Ryan P. McMillan, Luciane S. Martello, Lance H. Baumgard, Joshua T. Selsby, Matthew W. Hulver, Robert P. Rhoads
Summary: Heat stress disrupts substrate regulation and energy expenditure in growing pigs, leading to decreased muscle metabolic flexibility and increased leucine oxidation. However, weight gain and feed intake did not differ significantly between the HS and TN groups.
Article
Biology
Tori E. Rudolph, Edith J. Mayorga, Melissa Roths, Robert P. Rhoads, Lance H. Baumgard, Joshua T. Selsby
Summary: Heat stress poses a major threat to human health and agricultural production, with oxidative stress and mitochondrial dysfunction playing key roles in muscle injury. Mitoquinol is hypothesized to alleviate these effects. Unexpectedly, in male pigs exposed to heat stress, markers of oxidative stress were similar between treatments, while increased degradation of autophagosomes was observed. Previous findings in female pigs did not align with these results, suggesting potential sex-related differences in susceptibility to heat-induced injury.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Edith J. Mayorga, Erin A. Horst, Brady M. Goetz, Sonia Rodriguez-Jimenez, Megan A. Abeyta, Mohmmad Al-Qaisi, Samantha Lei, Robert P. Rhoads, Joshua T. Selsby, Lance H. Baumgard
Summary: The study aimed to investigate the effects of rapamycin on biomarkers of metabolism and inflammation in growing pigs under acute heat stress conditions. Despite altered phenotypic, metabolic, and leukocyte responses in pigs exposed to heat stress, rapamycin administration had limited impact on the measured outcomes.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Kellie A. Kroscher, Dane W. Fausnacht, Ryan P. McMillan, Samer W. El-Kadi, Emma H. Wall, David M. Bravo, Robert P. Rhoads
Summary: This study investigated the effects of supplementing a combination of an artificial high-intensity sweetener and capsaicin on pigs experiencing heat stress. The results indicated that supplementation restored core temperature, weight gain, and feed efficiency in heat-stressed pigs, while also improving metabolic flexibility. This suggests that the supplement has potential therapeutic metabolic effects during heat stress.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
J. W. Stewart, A. G. Arneson, M. K. H. Byrd, V. M. Negron-Perez, H. M. Newberne, R. R. White, S. W. El-Kadi, A. D. Ealy, R. P. Rhoads, M. L. Rhoads
Summary: This study aimed to investigate the effects of hyperinsulinemia concurrent with hypoglycemia on the physiological changes in lactating dairy cows under heat stress. The results showed that heat stress and hyperinsulinemia with hypoglycemia both had an impact on feed intake and milk production in cows. Furthermore, baseline blood glucose concentrations were highly correlated with the change in glucose levels during heat stress, and cows that did not develop hypoglycemia during heat stress tended to have a greater reduction in milk yield. This study fills a knowledge gap in understanding the physiological response to heat stress and changes in glycemic state.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Dallas R. Soffa, Jacob W. Stewart, Erica D. Pack, Alicia G. Arneson, Raffaella De Vita, James W. Knight, Dane W. Fausnacht, Robert P. Rhoads, Sherrie G. Clark, David G. Schmale, Michelle L. Rhoads
Summary: This study evaluated the effects of short-term consumption of zearalenone on growth, carcass weight, liver weight, and reproductive tissues in pubertal gilts. The results showed that short-term consumption of zearalenone produced microscopic alterations in reproductive organs, which are likely to have negative effects on their subsequent function and these differences persist even after zearalenone consumption ceases.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
M. Roths, M. A. Abeyta, B. Wilson, T. E. Rudolph, M. B. Hudson, R. P. Rhoads, L. H. Baumgard, J. T. Selsby
Summary: Heat stress does not increase skeletal muscle proteolysis, contrary to previous beliefs, which calls into question the assumption that increased skeletal muscle proteolysis drives increased amino acid mobilization.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
V. C. Souza, L. E. Moraes, L. H. Baumgard, J. E. P. Santos, N. D. Mueller, R. P. Rhoads, E. Kebreab
Summary: The goal of this study was to model the changes in dairy cow productivity, water intake, and absolute CH4 emissions, yield, and intensity with the progression of a cyclical heat stress period in lactating dairy cows. The study provides quantitative predictions of the changes in animal performance and CH4 emissions with the progression of heat stress in lactating dairy cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Wei Zhang, Robert Murray, Grace Barkley, Nikki Singh, Robert P. Rhoads, Chad H. Stahl
Meeting Abstract
Zoology
Mesa B. Cruz, R. Rhoads, L. Zhao, K. Kroscher, J. Brown, M. Kelly
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2019)