4.5 Article

Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition

期刊

JOURNAL OF ALZHEIMERS DISEASE
卷 59, 期 2, 页码 695-705

出版社

IOS PRESS
DOI: 10.3233/JAD-170092

关键词

Aging; cognition; dementia; neuroimaging

资金

  1. Academy of Finland [278457, 287490, 294061, 258981]
  2. Kuopio University Hospital
  3. UEF
  4. European Union 7th Framework Program for research, technological development and demonstration VPH-DARE@IT [601055]
  5. Turku University Hospital, Oulu University Hospital, Oulu City
  6. South Ostrobothnia Central Hospital, Faculty of Health Sciences (University of Eastern Finland)
  7. Fund of Mauri and Sirkka Wiljasalo
  8. Finnish Cultural Foundation North Savo Regional Fund
  9. Academy of Finland, EU Joint Programme - Neurodegenerative Disease Research, JPND [291803]
  10. Academy of Finland (AKA) [258981, 278457, 258981] Funding Source: Academy of Finland (AKA)

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Background: CAIDE Dementia Risk Score is the first validated tool for estimating dementia risk based on a midlife risk profile. Objectives: This observational study investigated longitudinal associations of CAIDE Dementia Risk Score with brain MRI, amyloid burden evaluated with PIB-PET, and detailed cognition measures. Methods: FINGER participants were at-risk elderly without dementia. CAIDE Risk Score was calculated using data from previous national surveys (mean age 52.4 years). In connection to baseline FINGER visit (on average 17.6 years later, mean age 70.1 years), 132 participants underwent MRI scans, and 48 underwent PIB-PET scans. All 1,260 participants were cognitively assessed (Neuropsychological Test Battery, NTB). Neuroimaging assessments included brain cortical thickness and volumes (Freesurfer 5.0.3), visually rated medial temporal atrophy (MTA), white matter lesions (WML), and amyloid accumulation. Results: Higher CAIDE Dementia Risk Score was related to more pronounced deep WML (OR 1.22, 95% CI 1.05-1.43), lower total gray matter (beta- coefficient -0.29, p = 0.001) and hippocampal volume (beta- coefficient -0.28, p = 0.003), lower cortical thickness (beta-coefficient -0.19, p = 0.042), and poorer cognition (beta-coefficients -0.31 for total NTB score, -0.25 for executive functioning, -0.33 for processing speed, and -0.20 for memory, all p < 0.001). Higher CAIDE Dementia Risk Score including APOE genotype was additionally related to more pronounced MTA (OR 1.15,95% CI 1.00-1.30). No associations were found with periventricular WML or amyloid accumulation. Conclusions: The CAIDE Dementia Risk Score was related to indicators of cerebrovascular changes and neurodegeneration on MRI, and cognition. The lack of association with brain amyloid accumulation needs to be verified in studies with larger sample sizes.

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Mascarenhas, Shariq R. Masoodi, Ellisiv B. Mathiesen, Prashant Mathur, Alicia Matijasevich, Piotr Matlosz, Tandi E. Matsha, Victor Matsudo, Christina Mavrogianni, Artur Mazur, Jean Claude N. Mbanya, Shelly R. McFarlane, Stephen T. McGarvey, Martin McKee, Stela McLachlan, Rachael M. McLean, Scott B. McLean, Margaret L. McNairy, Breige A. McNulty, Sounnia Mediene Benchekor, Jurate Medzioniene, Parinaz Mehdipour, Kirsten Mehlig, Amir Houshang Mehrparvar, Aline Meirhaeghe, Jorgen Meisfjord, Christa Meisinger, Jesus D. Melgarejo, Marina Melkumova, Joao Mello, Fabian Mendez, Carlos O. Mendivil, Ana Maria B. Menezes, Geetha R. Menon, Gert B. M. Mensink, Maria Teresa Menzano, Indrapal I. Meshram, Diane T. Meto, Jie Mi, Kim F. Michaelsen, Nathalie Michels, Kairit Mikkel, Karolina Milkowska, Jody C. Miller, Olga Milushkina, Claudia S. Minderico, G. K. Mini, Juan Francisco Miquel, J. Jaime Miranda, Mohammad Reza Mirjalili, Daphne Mirkopoulou, Erkin Mirrakhimov, Marjeta Misigoj-Durakovic, Antonio Mistretta, Veronica Mocanu, Pietro A. Modesti, Sahar Saeedi Moghaddam, Bahram Mohajer, Mostafa K. Mohamed, Shukri F. Mohamed, Kazem Mohammad, Mohammad Reza Mohammadi, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Farnam Mohebi, Marie Moitry, Line T. Mollehave, Niels C. Moller, Denes Molnar, Amirabbas Momenan, Charles K. Mondo, Roger A. Montenegro Mendoza, Eric Monterrubio-Flores, Kotsedi Daniel K. Monyeki, Jin Soo Moon, Mahmood Moosazadeh, Hermine T. Mopa, Farhad Moradpour, Leila B. Moreira, Alain Morejon, Luis A. Moreno, Francis Morey, Karen Morgan, Suzanne N. Morin, Erik Lykke Mortensen, George Moschonis, Alireza Moslem, Malgorzata Mossakowska, Aya Mostafa, Seyed-Ali Mostafavi, Anabela Mota-Pinto, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Marcos Andre Moura-dos-Santos, Yeva Movsesyan, Kelias P. Msyamboza, Thet Thet Mu, Magdalena Muc, Florian Muca, Boban Mugosa, Maria L. Muiesan, Martina Mueller-Nurasyid, Thomas Munzel, Jaakko Mursu, Elaine M. Murtagh, Kamarul Imran Musa, Sanja Music Milanovic, Vera Musil, Geofrey Musinguzi, Muel Telo M. C. Muyer, Iraj Nabipour, Shohreh Naderimagham, Gabriele Nagel, Farid Najafi, Harunobu Nakamura, Hanna Nalecz, Jana Namesna, Ei Ei K. Nang, Vinay B. Nangia, Martin Nankap, Sameer Narake, Paola Nardone, Take Naseri, Matthias Nauck, William A. Neal, Azim Nejatizadeh, Chandini Nekkantti, Keiu Nelis, Ilona Nenko, Martin Neovius, Flavio Nervi, Tze Pin Ng, Chung T. Nguyen, Nguyen D. Nguyen, Quang Ngoc Nguyen, Michael Y. Ni, Rodica Nicolescu, Peng Nie, Ramfis E. Nieto-Martinez, Yury P. Nikitin, Guang Ning, Toshiharu Ninomiya, Nobuo Nishi, Sania Nishtar, Marianna Noale, Oscar A. Noboa, Helena Nogueira, Maria Nordendahl, Borge G. Nordestgaard, Davide Noto, Natalia Nowak-Szczepanska, Mohannad Al Nsour, Irfan Nuhoglu, Baltazar Nunes, Eha Nurk, Fred Nuwaha, Moffat Nyirenda, Terence W. O'Neill, Dermot O'Reilly, Galina Obreja, Caleb Ochimana, Angelica M. Ochoa-Aviles, Eiji Oda, Augustine N. Odili, Kyungwon Oh, Kumiko Ohara, Claes Ohlsson, Ryutaro Ohtsuka, Orn Olafsson, Maria Teresa A. Olinto, Isabel O. Oliveira, Mohd Azahadi Omar, Saeed M. Omar, Altan Onat, Sok King Ong, N. Charlotte Onland-Moret, Lariane M. Ono, Pedro Ordunez, Rui Ornelas, Ana P. Ortiz, Pedro J. Ortiz, Merete Osler, Clive Osmond, Sergej M. Ostojic, Afshin Ostovar, Johanna A. Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Ioannis Pagkalos, Elena Pahomova, Karina Mary de Paiva, Andrzej Pajak, Alberto Palloni, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Arvind Pandey, Francesco Panza, Mariela Paoli, Sousana K. Papadopoulou, Dimitrios Papandreou, Rossina G. Pareja, Soon-Woo Park, Suyeon Park, Winsome R. Parnell, Mahboubeh Parsaeian, Ionela M. Pascanu, Patrick Pasquet, Nikhil D. Patel, Marcos Pattussi, Halyna Pavlyshyn, Raimund Pechlaner, Ivan Pecin, Mangesh S. Pednekar, Joao M. Pedro, Nasheeta Peer, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Marco A. Peres, Cynthia M. Perez, Valentina Peterkova, Annette Peters, Astrid Petersmann, Janina Petkeviciene, Ausra Petrauskiene, Olga Petrovna Kovtun, Emanuela Pettenuzzo, Niloofar Peykari, Norbert Pfeiffer, Modou Cheyassin Phall, Son Thai Pham, Rafael N. Pichardo, Daniela Pierannunzio, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Francesco Pistelli, Freda Pitakaka, Aleksandra Piwonska, Andreia N. Pizarro, Pedro Plans-Rubio, Alina G. Platonova, Bee Koon Poh, Hermann Pohlabeln, Nadija S. Polka, Raluca M. Pop, Stevo R. Popovic, Miquel Porta, Georg Posch, Anil Poudyal, Dimitrios Poulimeneas, Hamed Pouraram, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Alison J. Price, Jacqueline F. Price, Antonio Prista, Rui Providencia, Jardena J. Puder, Iveta Pudule, Maria Puiu, Margus Punab, Muhammed S. Qadir, Radwan F. Qasrawi, Mostafa Qorbani, Hedley K. Quintana, Pedro J. Quiroga-Padilla, Tran Quoc Bao, Stefan Rach, Ivana Radic, Ricardas Radisauskas, Salar Rahimikazerooni, Mahfuzar Rahman, Mahmudur Rahman, Olli Raitakari, Manu Raj, Tamerlan Rajabov, Sherali Rakhmatulloev, Ivo Rakovac, Sudha Ramachandra Rao, Ambady Ramachandran, Otim P. C. Ramadan, Virgilio V. Ramires, Jacqueline Ramke, Elisabete Ramos, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Lalka S. Rangelova, Vayia Rarra, Ramon A. Rascon-Pacheco, Cassiano Ricardo Rech, Josep Redon, Paul Ferdinand M. Reganit, Valeria Regecova, Jane D. P. Renner, Judit A. Repasy, Cezane P. Reuter, Luis Revilla, Abbas Rezaianzadeh, Yeunsook Rho, Lourdes Ribas-Barba, Robespierre Ribeiro, Elio Riboli, Adrian Richter, Fernando Rigo, Attilio Rigotti, Natascia Rinaldo, Tobias F. Rinke de Wit, Ana I. Rito, Raphael M. Ritti-Dias, Juan A. Rivera, Reina G. Roa, Louise Robinson, Cynthia Robitaille, Romana Roccaldo, Daniela Rodrigues, Fernando Rodriguez-Artalejo, Maria del Cristo Rodriguez-Perez, Laura A. Rodriguez-Villamizar, Andrea Y. Rodriguez, Ulla Roggenbuck, Peter Rohloff, Fabian Rohner, Rosalba Rojas-Martinez, Nipa Rojroongwasinkul, Dora Romaguera, Elisabetta L. Romeo, Rafaela V. Rosario, Annika Rosengren, Ian Rouse, Vanessa Rouzier, Joel G. R. Roy, Maira H. Ruano, Adolfo Rubinstein, Frank J. Ruhli, Jean-Bernard Ruidavets, Blanca Sandra Ruiz-Betancourt, Maria Ruiz-Castell, Emma Ruiz Moreno, Iuliia A. Rusakova, Kenisha Russell Jonsson, Paola Russo, Petra Rust, Marcin Rutkowski, Marge Saamel, Charumathi Sabanayagam, Hamideh Sabbaghi, Elena Sacchini, Harshpal S. Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Sare Safi, Saeid Safiri, Mohammad Hossien Saghi, Olfa Saidi, Nader Saki, Sanja Salaj, Benoit Salanave, Eduardo Salazar Martinez, Calogero Saleva, Diego Salmeron, Veikko Salomaa, Jukka T. Salonen, Massimo Salvetti, Margarita Samoutian, Jose Sanchez-Abanto, Ines Sanchez Rodriguez, Sandjaja, Susana Sans, Loreto Santa Marina, Ethel Santacruz, Diana A. Santos, Ina S. Santos, Lelita C. Santos, Maria Paula Santos, Osvaldo Santos, Rute Santos, Tamara R. Santos, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Thirunavukkarasu Sathish, Kai-Uwe Saum, Savvas Savva, Mathilde Savy, Norie Sawada, Mariana Sbaraini, Marcia Scazufca, Beatriz D. Schaan, Angelika Schaffrath Rosario, Herman Schargrodsky, Anja Schienkiewitz, Karin Schindler, Sabine Schipf, Carsten O. Schmidt, Ida Maria Schmidt, Andrea Schneider, Peter Schnohr, Ben Schottker, Sara Schramm, Stine Schramm, Helmut Schroder, Constance Schultsz, Matthias B. Schulze, Aletta E. Schutte, Sylvain Sebert, Moslem Sedaghattalab, Rusidah Selamat, Vedrana Sember, Abhijit Sen, Idowu O. Senbanjo, Sadaf G. Sepanlou, Guillermo Sequera, Luis Serra-Majem, Jennifer Servais, Ludmila Sevcikova, Svetlana Shalnova, Teresa Shamah-Levy, Seyed Morteza Shamshirgaran, Coimbatore Subramaniam Shanthirani, Maryam Sharafkhah, Sanjib K. Sharma, Jonathan E. Shaw, Amaneh Shayanrad, Ali Akbar Shayesteh, Lela Shengelia, Zumin Shi, Kenji Shibuya, Hana Shimizu-Furusawa, Tal Shimony, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Alfonso Siani, Rosalynn Siantar, Abla M. Sibai, Labros S. Sidossis, Natalia Silitrari, Antonio M. Silva, Caroline Ramos de Moura Silva, Diego Augusto Santos Silva, Kelly S. Silva, Xueling Sim, Mary Simon, Judith Simons, Leon A. Simons, Agneta Sjoberg, Michael Sjostrom, Natalia A. Skoblina, Gry Skodje, Tatyana Slazhnyova, Jolanta Slowikowska-Hilczer, Przemyslaw Slusarczyk, Liam Smeeth, Hung-Kwan So, Fernanda Cunha Soares, Grzegorz Sobek, Eugene Sobngwi, Morten Sodemann, Stefan Soderberg, Moesijanti Y. E. Soekatri, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Emily Sonestedt, Yi Song, Sajid Soofi, Thorkild I. A. Sorensen, Elin P. Sorgjerd, Charles Sossa Jerome, Victoria E. Soto-Rojas, Aicha Soumare, Alfonso Sousa-Poza, Slavica Sovic, Bente Sparboe-Nilsen, Karen Sparrenberger, Phoebe R. Spencer, Angela Spinelli, Igor Spiroski, Jan A. Staessen, Hanspeter Stamm, Kaspar Staub, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, George S. Stergiou, Jochanan Stessman, Ranko Stevanovic, Jutta Stieber, Doris Stockl, Jakub Stokwiszewski, Ekaterina Stoyanova, Gareth Stratton, Karien Stronks, Maria Wany Strufaldi, Lela Sturua, Ramon Suarez-Medina, Machi Suka, Chien-An Sun, Liang Sun, Johan Sundstrom, Yn-Tz Sung, Jordi Sunyer, Paibul Suriyawongpaisal, Nabil William G. Sweis, Boyd A. Swinburn, Rody G. Sy, Rene Charles Sylva, Moyses Szklo, Lucjan Szponar, Lorraine Tabone, E. Shyong Tai, Konstantinos D. Tambalis, Mari-Liis Tammesoo, Abdonas Tamosiunas, Eng Joo Tan, Xun Tang, Maya Tanrygulyyeva, Frank Tanser, Yong Tao, Mohammed Rasoul Tarawneh, Jakob Tarp, Carolina B. Tarqui-Mamani, Radka Taxova Braunerova, Anne Taylor, Julie Taylor, Felicite Tchibindat, Saskia Te Velde, William R. Tebar, Grethe S. Tell, Tania Tello, Yih Chung Tham, K. R. Thankappan, Holger Theobald, Xenophon Theodoridis, Nihal Thomas, Barbara Thorand, Betina H. Thuesen, Lubica Ticha, Erik J. Timmermans, Dwi H. Tjandrarini, Anne Tjonneland, Hanna K. Tolonen, Janne S. Tolstrup, Murat Topbas, Roman Topor-Madry, Liv Elin Torheim, Maria Jose Tormo, Michael J. Tornaritis, Maties Torrent, Laura Torres-Collado, Stefania Toselli, Giota Touloumi, Pierre Traissac, Thi Tuyet-Hanh Tran, Mark S. Tremblay, Areti Triantafyllou, Dimitrios Trichopoulos, Antonia Trichopoulou, Oanh T. H. Trinh, Atul Trivedi, Yu-Hsiang Tsao, Lechaba Tshepo, Maria Tsigga, Panagiotis Tsintavis, Shoichiro Tsugane, John Tuitele, Azaliia M. Tuliakova, Marshall K. Tulloch-Reid, Fikru Tullu, Tomi-Pekka Tuomainen, Jaakko Tuomilehto, Maria L. Turley, Gilad Twig, Per Tynelius, Evangelia Tzala, Themistoklis Tzotzas, Christophe Tzourio, Peter Ueda, Eunice Ugel, Flora A. M. Ukoli, Hanno Ulmer, Belgin Unal, Zhamyila Usupova, Hannu M. T. Uusitalo, Nalan Uysal, Justina Vaitkeviciute, Gonzalo Valdivia, Susana Vale, Damaskini Valvi, Rob M. van Dam, Bert-Jan van den Born, Johan Van der Heyden, Yvonne T. van der Schouw, Koen Van Herck, Wendy Van Lippevelde, Hoang Van Minh, Natasja M. Van Schoor, Irene G. M. van Valkengoed, Dirk Vanderschueren, Diego Vanuzzo, Anette Varbo, Gregorio Varela-Moreiras, Luz Nayibe Vargas, Patricia Varona-Perez, Senthil K. Vasan, Daniel G. Vasques, Tomas Vega, Toomas Veidebaum, Gustavo Velasquez-Melendez, Biruta Velika, Maite Verloigne, Giovanni Veronesi, W. M. Monique Verschuren, Cesar G. Victora, Giovanni Viegi, Lucie Viet, Froydis N. Vik, Monica Vilar, Salvador Villalpando, Jesus Vioque, Jyrki K. Virtanen, Sophie Visvikis-Siest, Bharathi Viswanathan, Mihaela Vladulescu, Tiina Vlasoff, Dorja Vocanec, Peter Vollenweider, Henry Volzke, Ari Voutilainen, Martine Vrijheid, Tanja G. M. Vrijkotte, Alisha N. Wade, Thomas Waldhor, Janette Walton, Elvis O. A. Wambiya, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Rildo de Souza Wanderley Junior, Ming-Dong Wang, Ningli Wang, Qian Wang, Xiangjun Wang, Ya Xing Wang, Ying-Wei Wang, S. Goya Wannamethee, Nicholas Wareham, Adelheid Weber, Karen Webster-Kerr, Niels Wedderkopp, Daniel Weghuber, Wenbin Wei, Aneta Weres, Bo Werner, Leo D. Westbury, Peter H. Whincup, Kremlin Wickramasinghe, Kurt Widhalm, Indah S. Widyahening, Andrzej Wiecek, Philipp S. Wild, Rainford J. Wilks, Johann Willeit, Peter Willeit, Julianne Williams, Tom Wilsgaard, Rusek Wojciech, Bogdan Wojtyniak, Kathrin Wolf, Roy A. Wong-McClure, Andrew Wong, Emily B. Wong, Jyh Eiin Wong, Tien Yin Wong, Jean Woo, Mark Woodward, Frederick C. Wu, Hon-Yen Wu, Jianfeng Wu, Li Juan Wu, Shouling Wu, Justyna Wyszynska, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Uruwan Yamborisut, Weili Yan, Ling Yang, Xiaoguang Yang, Yang Yang, Nazan Yardim, Tabara Yasuharu, Martha Yepez Garcia, Panayiotis K. Yiallouros, Agneta Yngve, Moein Yoosefi, Akihiro Yoshihara, Qi Sheng You, San-Lin You, Novie O. Younger-Coleman, Yu-Ling Yu, Yunjiang Yu, Safiah Md Yusof, Ahmad Faudzi Yusoff, Luciana Zaccagni, Vassilis Zafiropulos, Ahmad A. Zainuddin, Seyed Rasoul Zakavi, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Hana Zamrazilova, Maria Elisa Zapata, Abdul Hamid Zargar, Ko Ko Zaw, Ayman A. Zayed, Tomasz Zdrojewski, Magdalena Zeglen, Kristyna Zejglicova, Tajana Zeljkovic Vrkic, Yi Zeng, Luxia Zhang, Zhen-Yu Zhang, Dong Zhao, Ming-Hui Zhao, Wenhua Zhao, Yanitsa V. Zhecheva, Shiqi Zhen, Wei Zheng, Yingfeng Zheng, Bekbolat Zholdin, Maigeng Zhou, Dan Zhu, Marie Zins, Emanuel Zitt, Yanina Zocalo, Nada Zoghlami, Julio Zuniga Cisneros, Monika Zuziak, Zulfiqar A. Bhutta, Robert E. Black, Majid Ezzati

Summary: This study used data from 2,325 population-based studies to analyze the height and BMI of children and adolescents aged 5-19 years in urban and rural areas from 1990 to 2020. The results showed that the height advantage of urban residents over rural residents has decreased in most countries, while it has amplified in sub-Saharan Africa. The BMI difference between urban and rural areas is small in most countries, with faster BMI growth in urban areas observed in some regions.

NATURE (2023)

Article Public, Environmental & Occupational Health

Association of adiposity with morbidity in Finnish adults: A register-based follow-up study

Paeivi Maeki, Kennet Harald, Jaana Lindstroem, Satu Maennistoe, Tiina Laatikainen

Summary: The aim of this study was to update risk estimates of obesity related co-morbidities and provide evidence on the importance of obesity prevention. The study included participants aged 25-74 from the National FINRISK studies in 1997, 2002, and 2007. Results showed that overweight, obesity, and severe obesity were associated with various diseases including type 2 diabetes, gout, gallbladder diseases, and osteoarthritis. Prevention of obesity is crucial in reducing disease burden in the future.

SCANDINAVIAN JOURNAL OF PUBLIC HEALTH (2023)

Article Health Care Sciences & Services

Treatment gaps in the implementation of LDL cholesterol control among high- and very high-risk patients in Europe between 2020 and 2021: the multinational observational SANTORINI study

Kausik K. Ray, Inaam Haq, Aikaterini Bilitou, Marius C. Manu, Annie Burden, Carlos Aguiar, Marcello Arca, Derek L. Connolly, Mats Eriksson, Jean Ferrieres, Ulrich Laufs, Jose M. Mostaza, David Nanchen, Ernst Rietzschel, Timo Strandberg, Hermann Toplak, Frank L. J. Visseren, Alberico L. Catapano

Summary: The SANTORINI study found that in Europe between 2020 and 2021, statin monotherapy was the main approach to lipid management for high-risk and very high-risk cardiovascular patients, with only one-fifth achieving the recommended LDL-C goals. The study results raised questions about whether there have been changes in the treatment landscape or if gaps still exist.

LANCET REGIONAL HEALTH-EUROPE (2023)

Article Endocrinology & Metabolism

Factors affecting the effectiveness of the physical activity counselling intervention implemented in primary health care in adults with type 2 diabetes

Tuula Martiskainen, Marja-Leena Lamidi, Mika Venojaervi, Heikki Tikkanen, Tiina Laatikainen

Summary: This study evaluated the effectiveness of physical activity counseling in primary health care patients with Type 2 diabetes. The results showed that participants who attended counseling sessions more than three times had a significantly higher increase in physical activity. The study emphasizes the importance of an adequate amount and frequency of counseling sessions in lifestyle interventions.

BMC ENDOCRINE DISORDERS (2023)

Article Medicine, General & Internal

Associations between Liver Enzymes, Lifestyle Risk Factors and Pre-Existing Medical Conditions in a Population-Based Cross-Sectional Sample

Onni Niemela, Aini Bloigu, Risto Bloigu, Mauri Aalto, Tiina Laatikainen

Summary: Recent studies have shown that ALT and GGT enzymes can be used as predictive biomarkers for both liver dysfunction and extrahepatic morbidity. Lifestyle factors such as alcohol use, smoking, adiposity, physical inactivity, and coffee consumption significantly influence the activities of ALT and GGT. Close links have been found between hepatic and extrahepatic morbidities, lifestyle risk factors, and liver enzyme abnormalities.

JOURNAL OF CLINICAL MEDICINE (2023)

Article Geriatrics & Gerontology

Being actively engaged in life in old age: determinants, temporal trends, and prognostic value

Ulla L. Aalto, Mia Knuutila, Tuuli Lehti, Anu Jansson, Hannu Kautiainen, Hanna Ohman, Timo Strandberg, Kaisu H. Pitkala

Summary: Recently, the concept of successful ageing has shifted from healthy ageing to active ageing, which emphasizes the subjective perspective. This study aims to identify the determinants of being actively engaged in life (BAEL), explore the changes in BAEL over 3 decades, and investigate the prognostic value of BAEL.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2023)

Article Clinical Neurology

Combined Evidence for a Long-Term, Clinical Slowing Effect of Multinutrient Intervention in Prodromal Alzheimer's Disease: Post-Hoc Analysis of 3-Year Data from the LipiDiDiet Trial

Suzanne Hendrix, H. Soininen, A. Solomon, P. J. Visser, A. M. J. van Hees, D. S. Counotte, J. Nicodemus-Johnson, S. P. Dickson, K. Blennow, M. Kivipelto, T. Hartmann

Summary: The LipiDiDiet trial evaluated the long term effects of Fortasyn Connect on participants with prodromal AD. The analysis showed that the multinutrient intervention had a significant effect on cognition and global function, as measured by ADCOMS, GST, and BHM. Fortasyn Connect was associated with significantly less clinical decline over 36 months in prodromal AD.

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2023)

Correction Clinical Neurology

Alzheimer's Disease Composite Score: a Post-Hoc Analysis Using Data from the LipiDiDiet Trial in Prodromal Alzheimer's Disease (vol 6, pg 232, 2019)

Suzanne B. Hendrix, H. Soininen, A. M. J. van Hees, N. Ellison, P. J. Visser, A. Solomon, A. Attali, K. Blennow, M. Kivipelto, T. Hartmann

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2023)

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