Article
Clinical Neurology
Bo-Ching Lee, Hsin-Hsi Tsai, Chia-Ju Liu, Ya-Fang Chen, Li-Kai Tsai, Jiann-Shing Jeng, Ruoh-Fang Yen
Summary: This study found that cerebral venous reflux (CVR) is more closely associated with cerebral amyloid angiopathy (CAA) than hypertensive microangiopathy in intracerebral hemorrhage (ICH) survivors. The results suggest that venous drainage dysfunction potentially plays a role in CAA and cerebral amyloid deposition.
Article
Clinical Neurology
Susanne J. van Veluw, Konstantinos Arfanakis, Julie A. Schneider
Summary: Sporadic cerebral small vessel disease is a major cause of cognitive impairment and dementia in aging brains, characterized by brain small vessel abnormalities and frequently coexisting with Alzheimer disease changes. Ex vivo MRI is a powerful tool to bridge the gap in understanding the underlying neuropathology of MRI-detectable SVD abnormalities.
Review
Clinical Neurology
Konark Malhotra, Aikaterini Theodorou, Aristeidis H. Katsanos, Christina Zompola, Ashkan Shoamanesh, Efstathios Boviatsis, George P. Paraskevas, Martha Spilioti, Charlotte Cordonnier, David J. Werring, Andrei Alexandrov, Georgios Tsivgoulis
Summary: Limited data exist regarding the prevalence of clinical and neuroimaging manifestations among patients diagnosed with cerebral amyloid angiopathy (CAA). In this study, a systematic review and meta-analysis were conducted, revealing that approximately half of CAA patients have cerebral microbleeds, cortical superficial siderosis, mild cognitive impairment, dementia, intracerebral hemorrhage (ICH), or transient focal neurological episodes. Cortical superficial siderosis was the only neuroimaging marker associated with higher odds of ICH recurrence.
Article
Clinical Neurology
Suzanne E. van Dijk, Jeroen van der Grond, Jessie Lak, Annette van den Berg-Huysmans, Gerda Labadie, Gisela M. Terwindt, Marieke J. H. Wermer, M. Edip Gurol, Mark A. van Buchem, Steven M. Greenberg, Sanneke van Rooden
Summary: This study found that cerebrovascular reactivity worsens progressively in the presymptomatic phase of Dutch-type hereditary cerebral amyloid angiopathy (D-CAA). Recurrent intracerebral hemorrhage appears to be the most salient marker of progression in the symptomatic phase of the disease.
Article
Clinical Neurology
Shahram Oveisgharan, Lei Yu, Ana Capuano, Zoe Arvanitakis, Lisa L. Barnes, Julie A. Schneider, David A. Bennett, Aron S. Buchman
Summary: The study found that a higher cardiovascular Framingham risk score (FRS) in older adults is associated with higher odds of some cerebrovascular disease (CVD) pathologies, but with low discrimination at the individual level. Further work is needed to develop a more robust risk score to identify adults at risk for accumulating CVD pathologies.
Article
Clinical Neurology
Edgar Chan, Guendalina B. Bonifacio, Corin Harrison, Gargi Banerjee, Jonathan G. Best, Benjamin Sacks, Nicola Harding, Maria del Rocio Hidalgo Mas, H. Rolf Jager, Lisa Cipolotti, David J. Werring
Summary: This study investigated the cognitive function of patients with cerebral amyloid angiopathy (CAA) with and without intracerebral hemorrhage (ICH) and found that cognitive impairment is common in CAA, indicating the potential role of underlying neurodegeneration, possibly related to co-existing Alzheimer's disease pathology.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Whitney Marilyn Freeze, Susanne Janneke Van Veluw, Willemijn Josepha Jansen, David Alan Bennett, Heidi Irma Louisa Jacobs
Summary: This study investigated the link between locus coeruleus (LC) pathology and cerebral microangiopathy in two large neuropathology datasets. The findings suggest that LC pathology is associated with cerebral amyloid angiopathy and arteriolosclerosis, indicating a potential role of LC degeneration in the pathways relating vascular pathology to Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Houman Sotoudeh, Amir Hossein Sarrami, Jian-xiong Wang, Zahra Saadatpour, Ali Razaei, Siddhartha Gaddamanugu, Gagandeep Choudhary, Omid Shafaat, Aparna Singhal
Summary: With the increasing human life expectancy, there is a rise in the prevalence of neurodegenerative disorders and dementia, leading to ongoing research into various MRI sequences for accurate diagnosis. Susceptibility-weighted imaging (SWI) is an innovative technique sensitive to tissue susceptibility differences, particularly useful in detecting diagnostic clues related to iron deposition and microhemorrhages in the brain seen in these disorders. Familiarity with SWI findings is crucial for accurate diagnosis and management of neurodegenerative disorders.
JOURNAL OF NEUROIMAGING
(2021)
Review
Clinical Neurology
Gargi Banerjee, John Collinge, Nick C. Fox, Tammaryn Lashley, Simon Mead, Jonathan M. Schott, David J. Werring, Natalie S. Ryan
Summary: Cerebral amyloid angiopathy (CAA) is a significant cerebral small vessel disease that is associated with brain haemorrhage and cognitive change. While the common form affects individuals in mid- to later life, rare early-onset forms are increasingly recognized and may be caused by genetic or iatrogenic factors. This review provides an overview of the causes of early-onset CAA and proposes a structured approach for investigation and management, aiming to raise awareness among healthcare professionals.
Article
Clinical Neurology
Qi Li, Maria Clara Zanon Zotin, Andrew D. Warren, Yuan Ma, Edip Gurol, Joshua N. Goldstein, Steven M. Greenberg, Andreas Charidimou, Nicolas Raposo, Anand Viswanathan
Summary: This study found that cSAH detected in 40.5% of patients with acute lobar ICH related to CAA on CT is associated with an increased risk of recurrent ICH. cSAH may be used as a marker to stratify the risk of ICH in patients with CAA.
Article
Clinical Neurology
Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Erik van Zwet, Paul C. de Kruijff, Thijs W. van Harten, Ellis S. van Etten, Sanneke van Rooden, Louise van der Weerd, Mark A. van Buchem, Matthias J. P. van Osch, Steven M. Greenberg, Marianne A. A. van Walderveen, Gisela M. Terwindt, Marieke J. H. Wermer
Summary: Cortical calcifications are common in Dutch-type hereditary CAA (D-CAA) but rare in sporadic CAA. These calcifications are associated with the development of intracerebral hemorrhage (ICH) and may serve as a marker for advanced CAA. Additionally, there seems to be a link between cortical calcifications on computed tomography and the striped occipital cortex on 7T-magnetic resonance imaging.
Article
Clinical Neurology
Meng Zhang, Andrea B. Ganz, Susan Rohde, Linda Lorenz, Annemieke J. M. Rozemuller, Kimberley van Vliet, Marieke Graat, Sietske A. M. Sikkes, Marcel J. T. Reinders, Philip Scheltens, Marc Hulsman, Jeroen J. M. Hoozemans, Henne Holstege
Summary: Among 85 centenarians, levels of neuropathological substrates varied, and only Braak-NFT stage and LATE pathology significantly associated with cognitive performance. The clock-drawing test was particularly sensitive to levels of multiple neuropathologies.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Derrick N. Okine, David S. Knopman, Thomas H. Mosley, Dean F. Wong, Michelle C. Johansen, Keenan A. Walker, Clifford R. Jack Jr, Kejal Kantarci, James R. Pike, Jonathan Graff-Radford, Rebecca F. Gottesman
Summary: This study evaluated the association between CMB patterns and cerebral A beta deposition and found that a lobar-only pattern of CMBs or superficial siderosis is most strongly associated with brain A beta, while a mixed CMB pattern does not have an elevated risk.
Article
Clinical Neurology
Yuichiro Ii, Hidehiro Ishikawa, Akihiro Shindo, Hirofumi Matsuyama, Keita Matsuura, Kana Matsuda, Kimiko Yoshimaru, Masayuki Satoh, Ryota Kogue, Maki Umino, Masayuki Maeda, Hidekazu Tomimoto
Summary: The study found that the presence of CMIs with a high CAA-SVD score could be an indicator of more severe amyloid-associated vasculopathic changes in patients with probable CAA. CMIs were more frequently detected in the parietal and occipital lobes.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Jhih-Yong Yang, Yung-Tsai Chu, Hsin-Hsi Tsai, Jiann-Shing Jeng
Summary: This study retrospectively described two cases of CAA-ri and investigated the longitudinal changes of amyloid PET. The results showed focal decreases in amyloid load after the inflammatory process. The study also revealed variable findings related to amyloid burden in post-inflammatory regions in previously reported cases of CAA-ri with available amyloid PET.
FRONTIERS IN NEUROLOGY
(2023)
Review
Geriatrics & Gerontology
Akihiro Shindo, Hidehiro Ishikawa, Yuichiro Ii, Atsushi Niwa, Hidekazu Tomimoto
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Clinical Neurology
Shoko Sakano, Hirofumi Matsuyama, Hidehiro Ishikawa, Akihiro Shindo, Yuichiro Ii, Keita Matsuura, Minoru Mizutani, Norikazu Kawada, Hidekazu Tomimoto
Article
Clinical Neurology
Yuichiro Ii, Hidehiro Ishikawa, Akihiro Shindo, Hirofumi Matsuyama, Keita Matsuura, Kana Matsuda, Kimiko Yoshimaru, Masayuki Satoh, Ryota Kogue, Maki Umino, Masayuki Maeda, Hidekazu Tomimoto
Summary: The study found that the presence of CMIs with a high CAA-SVD score could be an indicator of more severe amyloid-associated vasculopathic changes in patients with probable CAA. CMIs were more frequently detected in the parietal and occipital lobes.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Yuichiro Ii, Hidehiro Ishikawa, Hirofumi Matsuyama, Akihiro Shindo, Keita Matsuura, Kimiko Yoshimaru, Masayuki Satoh, Akira Taniguchi, Kana Matsuda, Maki Umino, Masayuki Maeda, Hidekazu Tomimoto
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Medicine, General & Internal
Kana Matsuda, Akihiro Shindo, Yuichiro Ii, Ken-ichi Tabei, Yukito Ueda, Hidehiro Ishikawa, Keita Matsuura, Kimiko Yoshimaru, Akira Taniguchi, Natsuko Kato, Masayuki Satoh, Masayuki Maeda, Hidekazu Tomimoto
Summary: This study found significant associations between cerebral amyloid angiopathy (CAA) score and cognitive function, while the hypertensive arteriopathy (HA) score did not show clear association. The modified CAA-SVD score also had a significant correlation with cognitive function, indicating its potential as a predictor for cognitive deterioration in patients with mild cognitive impairment (MCI) and mild dementia.
Article
Clinical Neurology
Keita Matsuura, Yuichiro Ii, Masayuki Maeda, Ken-ichi Tabei, Masayuki Satoh, Maki Umino, Koichi Miyashita, Hidehiro Ishikawa, Akihiro Shindo, Hidekazu Tomimoto
Summary: Using neuromelanin-sensitive magnetic resonance imaging (NMI) can effectively differentiate neurodegenerative diseases like Parkinson's disease (PD) and progressive supranuclear palsy (PSP). The contrast ratio of the locus coeruleus (LC-CR) serves as a promising biomarker for distinguishing PD from PSP, with an area under the receiver-operating characteristic curve of 0.85.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Medicine, General & Internal
Takayuki Kondo, Haruhiko Banno, Taro Okunomiya, Yoko Amino, Kayoko Endo, Akiyoshi Nakakura, Ryuji Uozumi, Akemi Kinoshita, Harue Tada, Satoshi Morita, Hidehiro Ishikawa, Akihiro Shindo, Ken Yasuda, Yosuke Taruno, Takakuni Maki, Takashi Suehiro, Kohji Mori, Manabu Ikeda, Koji Fujita, Yuishin Izumi, Kazutomi Kanemaru, Kenji Ishii, Kazue Shigenobu, Yumiko Kutoku, Yoshihide Sunada, Shinobu Kawakatsu, Shunji Shiota, Toshifumi Watanabe, Osamu Uchikawa, Ryosuke Takahashi, Hidekazu Tomimoto, Haruhisa Inoue
Summary: AD is a common cause of dementia, with PSEN1 gene mutations being a frequent cause. Current treatments for PSEN1-AD are limited, but iPSC-based drug repurposing identified bromocriptine as a therapeutic candidate. A multicentre trial will investigate the safety and efficacy of bromocriptine in PSEN1-AD patients, with primary outcomes focusing on cognitive and psychological function. The study is conducted ethically and results will be disseminated at conferences and published in journals.
Article
Cell Biology
Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Hidehiro Ishikawa, Kelly K. Chung, Emiri T. Mandeville, Josephine Lok, Myriam Fornage, Karl Herrup, Kai-Hei Tse, Eng H. Lo, Ken Arai
Summary: White matter damage caused by cerebral hypoperfusion is a major feature of SIVD, and studying transcriptomic profiles of hypoperfused mice may lead to potential therapeutic targets for SIVD in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Hidehiro Ishikawa, Caleigh Mandel-Brehm, Akihiro Shindo, Martha A. Cady, Sabrina A. Mann, Atsushi Niwa, Koichi Miyashita, Yuichiro Ii, Kelsey C. Zorn, Akira Taniguchi, Masayuki Maeda, Michael R. Wilson, Joseph L. DeRisi, Hidekazu Tomimoto
Summary: This study identified the long-term radiological changes, autoantibody specificities, and clinical course in a patient with KLHL11-associated paraneoplastic neurological syndrome. The patient presented with progressive ataxia and sensorineural hearing loss, and immunotherapy was partially effective in treating his symptoms. Brain imaging revealed brainstem and cerebellar atrophy with signal changes on SWI, suggesting that KLHL11-PNS should be considered in differential diagnosis for similar cases.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naohiro Egawa, Gen Hamanaka, Kelly K. Chung, Hidehiro Ishikawa, Akihiro Shindo, Takakuni Maki, Ryosuke Takahashi, Haruhisa Inoue, Eng H. Lo, Ken Arai
Summary: This study demonstrates that HMGA1 may participate in the process of OPC differentiation by regulating the mRNA expression level of myelin-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Hirofumi Matsuyama, Keita Matsuura, Hidehiro Ishikawa, Yoshinori Hirata, Natsuko Kato, Atsushi Niwa, Yugo Narita, Hidekazu Tomimoto
Summary: The study found a negative correlation between zinc levels and levodopa dosage and frequency, indicating that frequent levodopa administration can affect serum zinc levels. Multiple regression analysis showed a significant correlation between the frequency of levodopa and serum zinc levels, and no significant change in clinical symptoms was observed after zinc supplementation, although anxiety tended to improve.
Article
Geriatrics & Gerontology
Ryo Ohtomo, Hidehiro Ishikawa, Keita Kinoshita, Kelly K. Chung, Gen Hamanaka, Gaku Ohtomo, Hajime Takase, Christiane D. Wrann, Hiroshi Katsuki, Atsushi Iwata, Josephine Lok, Eng H. Lo, Ken Arai
Summary: Clinical and basic research have shown that exercise is effective in improving cognitive function in cerebrovascular diseases, including SIVD. However, a study using middle-aged mice as a model of SIVD found that treadmill exercise only had limited effects on cognitive function in aging populations.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Yamato Nishiguchi, Keita Matsuura, Yoshinori Hirata, Akane Mizutani, Natsuko Katoh, Hidehiro Ishikawa, Koichi Miyashita, Takaya Utsunomiya, Hiroyuki Kajikawa, Hirofumi Nishikawa, Tomohiro Araki, Akihiro Shindo, Hidekazu Tomimoto
Summary: Research suggests that post-DBS frontal subcortical edema may lead to transient cognitive decline, while peri-STN edema may impact motor function and reduce the need for tuning.
Article
Clinical Neurology
Sanem A. Aykan, Hongyu Xie, Yi Zheng, David Y. Chung, Sreekanth Kura, James Han Lai, Taylan D. Erdogan, Andreia Morais, Isra Tamim, Damla Yagmur, Hidehiro Ishikawa, Ken Arai, M. Abbas Yaseen, David A. Boas, Sava Sakadzic, Cenk Ayata
Summary: Delayed treatment with fasudil improves functional recovery after focal subcortical white matter lesion in mice, despite worse initial connectivity loss.
Review
Endocrinology & Metabolism
Hidehiro Ishikawa, Akihiro Shindo, Akane Mizutani, Hidekazu Tomimoto, Eng H. Lo, Ken Arai
Summary: Vascular cognitive impairment (VCI) encompasses various cognitive disorders caused by cerebrovascular diseases, including vascular mild cognitive impairment, post-stroke dementia, and subcortical ischemic vascular dementia (SIVD). Among these, SIVD has received significant attention due to its similarities with Alzheimer's disease and the prevalence of small vessel pathologies in elderly individuals. Experimental models using mice have provided insights into the mechanisms and potential therapeutic targets for SIVD, which is characterized by cerebral hypoperfusion-induced brain damage.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)