Article
Clinical Neurology
Minesh Kapadia, M. Firoz Mian, Donglai Ma, Craig P. Hutton, Amber Azam, Klotilda Narkaj, Chuanhai Cao, Breanna Brown, Bernadeta Michalski, David Morgan, Paul Forsythe, Iva B. Zovkic, Margaret Fahnestock, Boris Sakic
Summary: Immunosuppression in 3xTg-AD mice prevented certain AD pathology features in males and maintained AD-like phenotype in females. This suggests a potential key role of autoimmunity in the pathogenesis of AD.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Neurosciences
Dominic I. Javonillo, Kristine M. Tran, Jimmy Phan, Edna Hingco, Enikoe A. Kramar, Celia da Cunha, Stefania Forner, Shimako Kawauchi, Giedre Milinkeviciute, Angela Gomez-Arboledas, Jonathan Neumann, Crystal E. Banh, Michelle Huynh, Dina P. Matheos, Narges Rezaie, Joshua A. Alcantara, Ali Mortazavi, Marcelo A. Wood, Andrea J. Tenner, Grant R. MacGregor, Kim N. Green, Frank M. LaFerla
Summary: Animal models are important for studying disease mechanisms and potential treatments, but the availability of numerous animal models presents challenges for Alzheimer's disease (AD) researchers. In this study, the 3xTg-AD mouse model was analyzed to understand the specific pathologies that develop at different ages and to comment on changes since its development 20 years ago. The study also compared the 3xTg-AD model with the 5xFAD model and found that plasma NfL is influenced by plaque burden. The results are freely available for researchers and demonstrate the usefulness of a standardized characterization pipeline for investigating and comparing different AD models.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Kelly Ceyzeriat, Benjamin B. Tournier, Philippe Millet, Giovanna Dipasquale, Nikolaos Koutsouvelis, Giovanni B. Frisoni, Valentina Garibotto, Thomas Zilli
Summary: This study found that low-dose radiation therapy (LD-RT) reduced amyloid load and possibly neuroinflammation markers in early-stage Alzheimer's disease, but did not impact tauopathy.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Alexandre Androuin, Manon Thierry, Susana Boluda, Asha Baskaran, Dominique Langui, Charles Duyckaerts, Marie-Claude Potier, Khalid Hamid El Hachimi, Benoit Delatour, Serge Marty
Summary: This study investigates the subcellular localization of Aβ fibrils in transgenic mouse models and human brain tissue of Alzheimer's disease (AD). Results show the accumulation of Aβ fibrils in intralysosomal lipofuscin granules in mice and undigested material in enlarged lipofuscin granules in human cortical biopsies. However, no intraneuronal accumulations of Aβ fibrils were detected in the examined samples.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Amanda Ferreira Neves, Christian Camargo, Courtney Premer, Joshua M. Hare, Bernard S. Baumel, Milena Pinto
Summary: The study demonstrates that the timing and frequency of MSC injections can impact various aspects of AD-like neuropathology in the 3xTg-AD mouse model. Single-dose MSC injections in young mice reduced neuroinflammation, while multiple doses affected beta-secretase cleavage and tau phosphorylation. Multiple-dose MSC injections also showed differing effects on tau phosphorylation at different sites in young and old mice.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anton Meinicke, Wolfgang Haertig, Karsten Winter, Joana Puchta, Bianca Mages, Dominik Michalski, Alexander Emmer, Markus Otto, Karl-Titus Hoffmann, Willi Reimann, Matthias Krause, Stefan Schob
Summary: The classic surfactant proteins have important roles in the lungs and brain. A novel surfactant protein, SP-G, is linked to inflammation in the lungs and is also present in the brain, particularly elevated after hemorrhage in premature infants and in conditions affecting cerebrospinal fluid. This study suggests that SP-G might play a role in the pathophysiology of Alzheimer's disease.
Article
Geriatrics & Gerontology
Benke Xu, Yun He, Lian Liu, Guosheng Ye, Lulu Chen, Qingning Wang, Michael Chen, Yuncai Chen, Dahong Long
Summary: Memory loss is a key symptom of Alzheimer's disease. This study investigated the effects of prolonged physical running on spatial memory in a rodent model of AD. The results showed that running improved hippocampal-dependent spatial memory in AD mice by preventing the loss of synaptic contacts and slowing down amyloid pathology.
Article
Cell Biology
Fei Yan, Ju Liu, Mei-Xiang Chen, Ying Zhang, Sheng-Jiao Wei, Hai Jin, Jing Nie, Xiao-Long Fu, Jing-Shan Shi, Shao-Yu Zhou, Feng Jin
Summary: Icariin improves learning and memory impairments in an Alzheimer's disease mouse model by regulating brain insulin signaling and glucose transporters.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Thomas S. Webberley, Ryan J. Bevan, Joshua Kerry-Smith, Jordanna Dally, Daryn R. Michael, Sophie Thomas, Meg Rees, James E. Morgan, Julian R. Marchesi, Mark A. Good, Sue F. Plummer, Duolao Wang, Timothy R. Hughes
Summary: This study assessed the neuroprotective potential of the Lab4P probiotic consortium in aging and metabolic syndrome-associated neurodegenerative pathologies. The results showed that supplementation with probiotics prevented cognitive decline, hippocampal neuron deterioration, and inflammation in mice. In human cell culture models, probiotic metabolites demonstrated a neuroprotective capability against beta-amyloid challenge. Overall, these findings suggest that Lab4P has the potential to be a neuroprotective agent and support further research in other neurodegenerative conditions in animal models and human studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yesica Gloria, Kelly Ceyzeriat, Stergios Tsartsalis, Philippe Millet, Benjamin B. Tournier
Summary: This study identified early dopaminergic dysfunction in a mouse model of AD, suggesting potential consequences for behavior and cognitive function, and providing insights into future therapeutic strategies.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Hao Fang, Guo Zhou, Qingli Li, Haichao Wang, Xiaobin Pang, Qing Xu, Yunzhou Yu
Summary: The novel recombinant chimeric vaccine showed significant immunogenicity and neuroprotective effects in AD mice, making it a promising candidate for the prophylaxis of Alzheimer's disease.
CURRENT MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tatsuhiro Ayabe, Chika Takahashi, Rena Ohya, Yasuhisa Ano
Summary: Beta-lactolin improves mitochondrial functions and prevents neuronal cell death in Alzheimer's disease-related neuronal cell models, demonstrating its advantage in maintaining neuronal health.
Article
Biochemistry & Molecular Biology
Daniel Alveal-Mellado, Lidia Castillo-Mariqueo, Lydia Gimenez-Llort
Summary: The study showed that mice with exercise training exhibited higher levels of horizontal exploration in the open field test. There were sex-dependent differences in voluntary wheel running activity, with high-NIBI males running less than high-NIBI females. This may be influenced by NPS-like symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Mo-Kyung Sin, Edward Zamrini, Ali Ahmed, Kwangsik Nho, Ihab Hajjar
Summary: Anti-amyloid therapies (AATs) are emerging treatments for early Alzheimer's disease (AD). However, they may cause abnormal signals in the brain, known as amyloid-related imaging abnormalities (ARIA). Cerebral amyloid angiopathy (CAA) is a major risk factor for ARIA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Geriatrics & Gerontology
Michelle M. M. Sonsalla, Dudley W. W. Lamming
Summary: Alzheimer's disease (AD) is an age-associated neurodegenerative disease with increasing prevalence due to the aging population. Traditional drug development efforts for AD have been largely unsuccessful. However, targeting aging itself through geroprotective interventions shows potential for preventing or treating AD.
Article
Pharmacology & Pharmacy
Laia Montoliu-Gaya, Jofre Guell-Bosch, Gisela Esquerda-Canals, Alejandro R. Roda, Gabriel Serra-Mir, Silvia Lope-Piedrafita, Jose Luis Sanchez-Quesada, Sandra Villegas
BIOCHEMICAL PHARMACOLOGY
(2018)
Article
Neurosciences
Laia Montoliu-Gaya, Sandra D. Mulder, Maaike A. C. Herrebout, Johannes C. Baayen, Sandra Villegas, Robert Veerhuis
MOLECULAR AND CELLULAR NEUROSCIENCE
(2018)
Review
Neurosciences
Alejandro R. Roda, Laia Montoliu-Gaya, Sandra Villegas
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Aleyda Benitez-Arnaro, Chiara Pallara, Laura Nasarre, Andrea Rivas-Urbina, Sonia Benitez, Angela Vea, Olga Bornachea, David de Gonzalo-Calvo, Gabriel Serra-Mir, Sandra Villegas, Roger Prades, Jose Luis Sanchez-Quesada, Cristina Chiva, Eduard Sabido, Teresa Tarrago, Vicenta Llorente-Cortes
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2019)
Article
Neurosciences
Gisela Esquerda-Canalsa, Alejandro R. Roda, Joaquim Marti-Clua, Laia Montoliu-Gaya, Geovanny Rivera-Hernandez, Sandra Villegas
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Multidisciplinary Sciences
Gisela Esquerda-Canals, Joaquim Marti-Clua, Sandra Villegas
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Rivas Urbina, A. Rull, S. Villegas, J. C. Escola Gil, J. Ordonez Llanos, J. L. Sanchez Quesada
Article
Biochemistry & Molecular Biology
Andrea Rivas-Urbina, Anna Rull, Laia Montoliu-Gaya, Montserrat Perez-Cuellar, Jordi Ordonez-Llanos, Sandra Villega, Jose Luis Sanchez-Quesada
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2020)
Article
Biophysics
J. Guell-Bosch, S. Lope-Piedrafita, G. Esquerda-Canals, L. Montoliu-Gaya, S. Villegas
NMR IN BIOMEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Alejandro R. Roda, Laia Montoliu-Gaya, Gabriel Serra-Mir, Sandra Villegas
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Alejandro R. Roda, Gisela Esquerda-Canals, Joaquim Marti-Clua, Sandra Villegas