期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 60, 期 1, 页码 323-332出版社
IOS PRESS
DOI: 10.3233/JAD-170014
关键词
Cognition; dementia; exercise; residential facilities
资金
- Swedish Research Council [K2009-69P-21298-01-4, K2009-69X-21299-01-1, K2009-69P-21298-04-4, K2014-99X-22610-01-6]
- Forte - Swedish Research Council for Health, Working Life and Welfare [2012-0775]
- Vardal Foundation
- Swedish Dementia Association
- Promobilia Foundation
- Swedish Society of Medicine
- Swedish Alzheimer Foundation
- King Gustav V and Queen Victoria's Foundation of Freemasons
- County Council of Vasterbotten
- Umea University Foundation for Medical Research
- Ragnhild and Einar Lundstrom's Memorial Foundation
- Erik and Anne-Marie Detlof's Foundation
Background: Although physical exercise has been suggested to influence cognitive function, previous exercise studies show inconsistent results in people with dementia. Objectives: To investigate effects of exercise on cognitive function in people with dementia. Method: The Umea a Dementia and Exercise (UMDEX) study, a cluster-randomized controlled trial, was set in 16 nursing homes in Umea, Sweden. One hundred-and-forty-one women and 45 men with dementia; mean age of 85 y and mean MiniMental State Examination (MMSE) score of 15, were randomized to a High-Intensity Functional Exercise program or a seated attention control activity. Blinded assessors measured global cognitive function using the MMSE and the Alzheimer's disease Assessment Scale -Cognitive subscale (ADAS-Cog), and executive function using Verbal fluency (VF) at baseline and 4 months (directly after intervention completion), and MMSE and VF at 7 months. Results: Linear mixed models showed no between-group effects in mean difference from baseline (95% confidence intervals, CI) at 4 months in MMSE (-0.27; 95% CI -1.4 to 0.87, p = 0.644), ADAS-Cog (-1.04, 95% CI -4 to 1.92, p = 0.491), or VF (-0.53, 95% CI -1.42 to 0.35, p = 0.241) or at 7 months in MMSE (-1.15, 95% CI -2.32 to 0.03, p = 0.056) or VF (-0.18, 95% CI -1.09 to 0.74, p = 0.707). Conclusion: A 4-month, high-intensity functional exercise program had no superior effects on global cognition or executive function in people with dementia living in nursing homes when compared with an attention control activity.
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