Article
Cardiac & Cardiovascular Systems
Hang Guo, Yi Tan, Zhizheng Yao, Zilu Zhang, Jiafu Yan, Xiaofeng Meng
Summary: High blood pressure variability and hypertension are risk factors for mild cognitive impairment and probable dementia. This study found that higher systolic blood pressure variability and pulse pressure variability were associated with an increased risk of probable dementia in the intensive group, while higher systolic blood pressure variability was associated with an increased risk of mild cognitive impairment in the intensive group. These findings emphasize the importance of monitoring blood pressure variability in intensive blood pressure treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Jiachen Yu, Qirui Song, JingJing Bai, Shouling Wu, Peili Bu, YuFeng Li, Jun Cai
Summary: This study investigated the relationship between visit-to-visit blood pressure variability (BPV) and cardiovascular events in hypertensive patients. The results showed that visit-to-visit diastolic BPV was associated with adverse health outcomes in the standard treatment group, but not in the intensive treatment group.
Article
Geriatrics & Gerontology
Isabel J. Sible, Belinda Yew, Shubir Dutt, Katherine J. Bangen, Yanrong Li, Daniel A. Nation
Summary: Research shows that increased blood pressure variability in older adults is associated with a decline in regional cerebral perfusion, potentially serving as an early marker of vascular dysfunction in aging.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Isabel J. Sible, Daniel A. Nation
Summary: This study examined the longitudinal relationship between blood pressure variability (BPV) and cognitive change, and found that higher systolic BPV was associated with greater decline in memory and language abilities among APOE ε4 carriers. However, no association was observed between systolic BPV and cognitive change in APOE ε3 homozygotes.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Isabel J. Sible, Katherine J. Bangen, Anna E. Blanken, Jean K. Ho, Daniel A. Nation
Summary: Elevated blood pressure variability is associated with postmortem cerebrovascular lesion burden in autopsy-confirmed AD, independent of average blood pressure and AD neuropathology. Blood pressure fluctuation may selectively promote specific cerebrovascular lesions, with potential implications for cognitive impairment and dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Peripheral Vascular Disease
Xiaoyong Xu, Xianghong Meng, Shin-Ichi Oka
Summary: The study revealed that long-term engagement in vigorous physical activity is associated with lower visit-to-visit systolic blood pressure variability, with a negative linear trend between the frequency of vigorous physical activity and systolic blood pressure variability.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Wei-guo Fan, Wen-ying Wang, Ya-xing Meng, James E. Sharman, Gianfranco Parati, Norm R. C. Campbell, Hai Su
Summary: In a general population, the variability of blood pressure readings within an initial clinic visit is associated with the variability within subsequent visits and the variability between visits over one week. The study found that the variability of blood pressure readings at the first visit was positively correlated with subsequent visits, overall blood pressure variability, and visit-to-visit blood pressure variability.
JOURNAL OF HYPERTENSION
(2021)
Article
Clinical Neurology
Taewon Kim, Dahyun Yi, Min Soo Byun, Hyejin Ahn, Joon Hyung Jung, Nayeong Kong, Min Jung Kim, Gijung Jung, Jun-Young Lee, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee
Summary: This study found a synergistic interaction between high current blood pressure and beta-amyloid and tau deposition in late-life, but no association with a history of hypertension. This suggests that strict blood pressure control is important for the prevention of Alzheimer's disease in cognitively normal older adults with hypertension.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Geriatrics & Gerontology
Laure Rouch, Philipe De Souto Barreto, Olivier Hanon, Jean-Sebastien Vidal, Jacques Amar, Sandrine Andrieu, Philippe Cestac, Yves Rolland, Bruno Vellas
Summary: Higher visit-to-visit blood pressure variability, especially in systolic blood pressure and pulse pressure, was significantly associated with an increased risk of incident frailty in elderly participants. Conversely, diastolic blood pressure and mean arterial pressure variability were not significantly associated with incident frailty. These findings suggest that blood pressure instability may serve as an early marker for frailty.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Food Science & Technology
Zhipeng Kan, Yijun Wang, Qian Chen, Xiaoyu Tang, Henry J. Thompson, Jinbao Huang, Jinsong Zhang, Feng Gao, Yong Shen, Xiaochun Wan
Summary: In this study, it was found that green tea extract treatment significantly improved spatial learning and memory ability in 5XFAD mice, reduced the formation of A beta, and decreased the levels of related proteins. GTE also suppressed glial cell activation and inflammatory responses, while increasing synaptic protein levels.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Geriatrics & Gerontology
Meilin She, Suhang Shang, Ningwei Hu, Chen Chen, Liangjun Dang, Ling Gao, Shan Wei, Kang Huo, Jingyi Wang, Jin Wang, Qiumin Qu
Summary: The study found that elevated blood pressure levels were positively correlated with increased plasma A beta(1-40) levels in middle-aged and elderly ApoE epsilon 4 non-carriers.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Yacoubou Abdoul Razak Mahaman, Jun Feng, Fang Huang, Maibouge Tanko Mahamane Salissou, Jianzhi Wang, Rong Liu, Bin Zhang, Honglian Li, Feiqi Zhu, Xiaochuan Wang
Summary: Alzheimer's disease is a global health problem with no effective single therapy. Nutraceutical agents like Moringa oleifera (MO), which have multiple effects, show promise in treating AD. This study found that MO treatment improved behavioral and cognitive deficits, reduced A beta burden, and improved synaptic plasticity and neurodegeneration in AD mice.
Editorial Material
Urology & Nephrology
Furkan Yavuz, Mehmet Kanbay
Summary: Blood pressure variability is strongly associated with an increased risk of dementia in patients with chronic kidney disease (CKD), including Alzheimer's and vascular dementia.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Jiandong Zhou, Sharen Lee, Wing Tak Wong, Keith Sai Kit Leung, Ronald Hang Kin Nam, Prudence Shun Hay Leung, Yau-Lam Alex Chau, Tong Liu, Carlin Chang, Bernard Man Yung Cheung, Gary Tse, Qingpeng Zhang
Summary: The study revealed that female and older patients are more likely to develop anxiety symptoms, especially when their blood pressure and blood pressure variability are high.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
MaoXiang Zhao, Siyu Yao, Yao Li, Miao Wang, Chi Wang, Cuijuan Yun, Sijin Zhang, Yizhen Sun, Ziwei Hou, Shouling Wu, Hao Xue
Summary: In hypertensive patients, high variability in SBP and RHR is independently associated with all-cause mortality, and high VVVs in SBP and RHR also additively increase the risk of mortality.
HYPERTENSION RESEARCH
(2021)
Article
Peripheral Vascular Disease
M. Nagai, K. Dote, M. Kato, S. Sasaki, N. Oda, E. Kagawa, Y. Nakano, A. Yamane, Y. Kubo, T. Higashihara, S. Miyauchi, W. Harada, H. Masuda
JOURNAL OF HUMAN HYPERTENSION
(2017)
Editorial Material
Cardiac & Cardiovascular Systems
Tasuku Higashihara, Michiaki Nagai, Keigo Dote, Masaya Kato, Noboru Oda, Eiji Kunita, Eisuke Kagawa, Aya Yamane, Yusuke Kobayashi, Haruko Shiota, Makoto Takeuchi
CORONARY ARTERY DISEASE
(2019)
Review
Pharmacology & Pharmacy
Shunsuke Miyauchi, Michiaki Nagai, Keigo Dote, Masaya Kato, Noboru Oda, Eiji Kunita, Eisuke Kagawa, Aya Yamane, Tasuku Higashihara, Arinori Takeuchi, Akane Tsuchiya, Kosuke Takahari
CURRENT PHARMACEUTICAL DESIGN
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Hiroki Ikenaga, Tasuku Higashihara, Kiho Itakura, Hiroto Utsunomiya, Yukihiro Fukuda, Taiichi Takasaki, Shinya Takahashi, Yukiko Nakano
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Kazuhiro Nitta, Yukihiro Fukuda, Kosuke Takahari, Atsushi Takeda, Tasuku Higashihara, Yuichi Morita, Noriaki Watanabe, Hiroki Ikenaga, Hiroto Utsunomiya, Ken Ishibashi, Satoshi Kurisu, Shinya Takahashi, Kazuo Awai, Yukiko Nakano
Summary: The study found that coronary artery disease is an independent predictor of delayed H/M ratio in patients with severe AS, and aortic valve area is an independent predictor of WR.
HEART LUNG AND CIRCULATION
(2022)
Article
Cardiac & Cardiovascular Systems
Yukihiro Fukuda, Kazuhiro Nitta, Yuichi Morita, Tasuku Higashihara, Atsushi Takeda, Takayuki Nakano, Yoshiharu Sada, Noriaki Watanabe, Hiroki Ikenaga, Yukiko Nakano
Summary: P-wave terminal force in lead V1 (PTFV1) is associated with left ventricular diastolic function, as derived from gated myocardial perfusion single-photon emission computed tomography (SPECT) in patients with no significant perfusion abnormalities.
INTERNATIONAL HEART JOURNAL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Takeuchi, M. Nagai, K. Dote, M. Kato, N. Oda, E. Kunita, E. Kagawa, A. Yamane, T. Higashihara, Y. Kobayashi, H. Shiota
EUROPEAN HEART JOURNAL
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Nagai, K. Dote, M. Kato, N. Oda, E. Kunita, E. Kagawa, A. Yamane, T. Higashihara, A. Takeuchi, A. Tsuchiya
EUROPEAN HEART JOURNAL
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
E. Kagawa, K. Dote, N. Oda, M. Nagai, T. Higashihara, A. Tsuchiya, M. Kato, E. Kunita, A. Yamane, A. Takeuchi
EUROPEAN HEART JOURNAL
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
E. Kagawa, K. Dote, M. Kato, N. Oda, E. Kunita, M. Nagai, A. Yamane, T. Higashihara, A. Takeuchi, A. Tsuchiya
EUROPEAN HEART JOURNAL
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
Michiaki Nagai, Keigo Dote, Masaya Kato, Noboru Oda, Eiji Kunita, Eisuke Kagawa, Aya Yamane, Tasuku Higashihara, Yusuke Kobayashi, Makoto Takeuchi
Review
Pharmacology & Pharmacy
Michiaki Nagai, Keigo Dote, Masaya Kato, Shota Sasaki, Noboru Oda, Eisuke Kagawa, Yoshinori Nakano, Aya Yamane, Tasuku Higashihara, Shunsuke Miyauchi, Akane Tsuchiya, Wakako Harada, Kazuomi Kario
CURRENT PHARMACEUTICAL DESIGN
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Tsuchiya, M. Nagai, K. Dote, M. Wakabayashi, K. Nakamura, M. Katou, S. Sasaki, N. Oda, E. Kagawa, Y. Nakano, A. Yamane, T. Higashihara
EUROPEAN HEART JOURNAL
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Nagai, K. Dote, M. Kato, S. Sasaki, N. Oda, E. Kagawa, Y. Nakano, A. Yamane, T. Higashihara, S. Miyauchi, A. Tsuchiya
EUROPEAN HEART JOURNAL
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
E. Kagawa, K. Dote, M. Kato, S. Sasaki, N. Oda, Y. Nakano, M. Nagai, T. Higashihara, S. Miyauchi, A. Tsuchiya
EUROPEAN HEART JOURNAL
(2017)
