Mathematical modeling of receptor occupancy data: A valuable technology for biotherapeutic drug development

Simulations of site-specific target-mediated pharmacokinetic models for guiding the development of bispecific antibodies

(2015) Vaishali L. Chudasama et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Quantitative Prediction of Human Pharmacokinetics for mAbs Exhibiting Target-Mediated Disposition

(2014) Aman P. Singh et al.   AAPS Journal

A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design

(2014) Jasmine P Davda et al.   mAbs

Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research

(2014) Tove Tuntland et al.   Frontiers in Pharmacology

Modeling, Simulation, and Translation Framework for the Preclinical Development of Monoclonal Antibodies

(2013) Kenneth T. Luu et al.   AAPS Journal

pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood

(2013) Ming Zhu et al.   Journal of Translational Medicine

Antibody biodistribution coefficients

(2013) Dhaval K. Shah et al.   mAbs

Quantitative Analysis of Target Coverage and Germinal Center Response by a CXCL13 Neutralizing Antibody in a T-Dependent Mouse Immunization Model

(2013) Joanne Brodfuehrer et al.   PHARMACEUTICAL RESEARCH

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

(2011) Paul Morgan et al.   DRUG DISCOVERY TODAY

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Theoretical Considerations of Target-Mediated Drug Disposition Models: Simplifications and Approximations

(2011) Peiming Ma   PHARMACEUTICAL RESEARCH

Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Nathanael L. Dirks et al.   CLINICAL PHARMACOKINETICS

On Setting the First Dose in Man: Quantitating Biotherapeutic Drug-Target Binding through Pharmacokinetic and Pharmacodynamic Models

(2009) Philip J. Lowe et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Development of a PBPK Model for Monoclonal Antibodies and Simulation of Human and Mice PBPK of a Radiolabelled Monoclonal Antibody

(2009) Tomi Heiskanen et al.   CURRENT PHARMACEUTICAL DESIGN

Target site occupancy: Emerging generalizations from clinical and preclinical studies

(2009) Sarah Grimwood et al.   PHARMACOLOGY & THERAPEUTICS

Population pharmacokinetic/ pharmacodynamic analysis of CCR5 receptor occupancy by maraviroc in healthy subjects and HIV-positive patients

(2008) Maria C. Rosario et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

In Vitro and Clinical Investigation of the Relationship Between CCR5 Receptor Occupancy and Anti-HIV Activity of Aplaviroc

(2008) James F. Demarest et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Approximations of the target-mediated drug disposition model and identifiability of model parameters

(2008) Leonid Gibiansky et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS