Article
Pediatrics
Chirag Thakur, Jogender Kumar, Prawin Kumar, Jagdish Prasad Goyal, Kuldeep Singh, Atul Gupta
Summary: The study found that vitamin D supplementation as an adjunct to standard treatment does not improve asthma control in children.
PEDIATRIC PULMONOLOGY
(2021)
Article
Nutrition & Dietetics
Alicja Kolodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka
Summary: A study was conducted to assess the effectiveness of monitored vitamin D supplementation in preterm infants. Results showed that a higher percentage of infants in the monitored group had safe vitamin D levels, while potential vitamin D toxicity was observed in the standard treatment group. Therefore, vitamin D intake should be between 800-1000 IU and monitored to avoid overdose.
Article
Geriatrics & Gerontology
Mary Waterhouse, Emma Sanguineti, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Dallas R. English, Bruce K. Armstrong, Peter R. Ebeling, Gunter Hartel, Michael G. Kimlin, Rachel L. O'Connell, Hai Pham, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: This study found that monthly high-dose vitamin D supplementation did not reduce the risk of falls, and may potentially increase the risk of falling in individuals with normal BMI. Further investigation is needed to better understand the impact of vitamin D supplementation on falls risk in different populations.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Orthopedics
Matthew T. Weintraub, Jonathan Guntin, JaeWon Yang, Anne DeBenedetti, Vasili Karas, Craig J. Della Valle, Denis Nam
Summary: This randomized controlled trial aimed to investigate the effects of a one-time dose of vitamin D3 prior to total knee arthroplasty. The results showed no significant improvements in functional scores, walking test times, or complications in the early postoperative period when compared to the placebo group.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Nutrition & Dietetics
Jyrki K. Virtanen, Tarja Nurmi, Antti Aro, Elizabeth R. Bertone-Johnson, Elina Hypponen, Heikki Kroger, Christel Lamberg-Allardt, JoAnn E. Manson, Jaakko Mursu, Pekka Mantyselka, Sakari Suominen, Matti Uusitupa, Ari Voutilainen, Tomi-Pekka Tuomainen, Sari Hantunen
Summary: A 5-year randomized trial found that vitamin D-3 supplementation did not reduce the incidences of major cardiovascular events or invasive cancer among older adults.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Josipa Domazet Bugarin, Svjetlana Dosenovic, Darko Ilic, Nikola Delic, Ivana Saric, Ivo Ugrina, Sanda Stojanovic Stipic, Bozidar Duplancic, Lenko Saric
Summary: COVID-19 symptoms range from asymptomatic cases to severe illness requiring hospitalization and intensive care. Low vitamin D levels have been associated with increased severity and mortality of COVID-19. However, this study found no significant benefit of vitamin D supplementation in patients with severe COVID-19 disease admitted to the ICU and in need of respiratory support.
Article
Clinical Neurology
P. N. Suresh Kumar, Vikas Menon, Chittaranjan Andrade
Summary: This study investigated the impact of vitamin D supplementation on depression treatment through a randomized controlled trial. The results showed that vitamin D supplementation did not improve the antidepressant effects of flexibly dosed escitalopram. Importantly, depressed patients with vitamin D deficiency may require higher antidepressant doses to experience similar benefits to those whose deficiency is corrected by vitamin D supplementation.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, General & Internal
Chao Luo, Yaning Sun, Zuojing Zeng, Ying Liu, Shunlin Peng
Summary: The efficacy of vitamin D supplementation in pregnant women, infants, or children for the prevention of allergies was reviewed in this study. The findings suggest that vitamin D supplementation does not have a significant effect on the primary prevention of allergic diseases.
CHINESE MEDICAL JOURNAL
(2022)
Article
Nutrition & Dietetics
Harriet Johansson, Giuseppe Spadola, Giulio Tosti, Mario Mandala, Alessandro M. Minisini, Paola Queirolo, Valentina Aristarco, Federica Baldini, Emilia Cocorocchio, Elena Albertazzi, Leonardo Zichichi, Saverio Cinieri, Costantino Jemos, Giovanni Mazzarol, Patrizia Gnagnarella, Debora Macis, Ines Tedeschi, Emanuela Omodeo Sale, Luigia Stefania Stucci, Bernardo Bonanni, Alessandro Testori, Elisabetta Pennacchioli, Pier Francesco Ferrucci, Sara Gandini
Summary: In a study involving newly resected stage II melanoma patients, adjuvant vitamin D3 significantly increased serum 25OHD levels, particularly in patients with a baseline Breslow score under 3 mm. Patients with low 25OHD levels and Breslow score >= 3 mm had shorter disease-free survival, suggesting a potential impact of vitamin D on melanoma prognosis. Larger trials with vitamin D supplementation in melanoma subjects are needed to further investigate these findings.
Article
Critical Care Medicine
Jagat Jeevan Ghimire, Kana Ram Jat, Jhuma Sankar, Rakesh Lodha, Venkat K. Iyer, Hitender Gautam, Seema Sood, S. K. Kabra
Summary: This study demonstrates that the use of azithromycin improves asthma control and reduces exacerbations in children with poorly controlled asthma.
Article
Nutrition & Dietetics
Andrea Aparicio, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua, Kathleen Lee-Sarwar, Yang-Yu Liu
Summary: The maternal gut microbiome and vitamin D deficiency during pregnancy have been separately associated with health problems. This study analyzed data from pregnant women in the VDAART to investigate the association between vitamin D level and gut microbiome. The results suggest that increasing vitamin D level during pregnancy may protect against the growth of certain bacteria.
Article
Nutrition & Dietetics
Shuangshuang Ma, Wanjun Yin, Peng Wang, Haixia Wang, Lei Zhang, Ruixue Tao, Honglin Hu, Xiaomin Jiang, Ying Zhang, Fangbiao Tao, Peng Zhu
Summary: This study aimed to assess the effect of vitamin D supplementation during pregnancy on glucose levels and identify factors influencing the response to vitamin D intake. The results showed that vitamin D supplementation significantly protected glucose homeostasis, and the response to vitamin D may be influenced by basal vitamin D levels, VDR gene polymorphism, and metabolic profiles.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Maryam Razaghi, Nathalie Gharibeh, Catherine A. Vanstone, Olusola F. Sotunde, Ali Khamessan, Shu Qin Wei, Dayre McNally, Frank Rauch, Glenville Jones, Sarah Kimmins, Hope A. Weiler
Summary: Supplementing with vitamin D during infancy improves vitamin D levels, and a daily dose of 1000 IU increases lean mass slightly.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Abolfazl Zendehdel, Mohsen Ansari, Farnaz Khatami, Shapour Mansoursamaei, Hossein Dialameh
Summary: This randomized clinical trial found that vitamin D has a significant effect in reducing prostate volume and PSA levels, improving BPH symptoms. Additionally, the intervention group showed a greater decrease in IPSS score compared to the control group.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Carlos A. Camargo, Les Toop, John Sluyter, Carlene M. M. Lawes, Debbie Waayer, Kay-Tee Khaw, Adrian R. Martineau, Robert Scragg
Summary: Randomized controlled trials have shown that vitamin D supplementation may not have an overall impact on the risk of exacerbations of asthma or COPD, but may have a potential benefit for individuals with severe vitamin D deficiency.
Article
Allergy
Mengdi Lu, Augusto A. Litonjua, George T. O'Connor, Robert S. Zeiger, Leonard Bacharier, Michael Schatz, Vincent J. Carey, Scott T. Weiss, Hooman Mirzakhani
Summary: Childhood asthma development is affected by a complex interplay of maternal asthma and prenatal vitamin D status. This study suggests that adequate vitamin D intake throughout pregnancy can help reduce the risk of childhood asthma exacerbated by maternal asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Wanda Phipatanakul, David T. Mauger, Theresa W. Guilbert, Leonard B. Bacharier, Sandy Durrani, Daniel J. Jackson, Fernando D. Martinez, Anne M. Fitzpatrick, Amparito Cunningham, Susan Kunselman, Lisa M. Wheatley, Cindy Bauer, Carla M. Davis, Bob Geng, Kirsten M. Kloepfer, Craig Lapin, Andrew H. Liu, Jacqueline A. Pongracic, Stephen J. Teach, James Chmiel, Jonathan M. Gaffin, Matthew Greenhawt, Meera R. Gupta, Peggy S. Lai, Robert F. Lemanske, Wayne J. Morgan, William J. Sheehan, Jeffrey Stokes, Peter S. Thorne, Hans C. Oettgen, Elliot Israel
Summary: Asthma in children is largely influenced by allergen sensitization, and early intervention targeting IgE and IgE-mediated responses may help prevent and reduce the severity of asthma development.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Allergy
Hanna M. Knihtila, Benjamin J. Stubbs, Vincent J. Carey, Nancy Laranjo, Su H. Chu, Rachel S. Kelly, Robert S. Zeiger, Leonard B. Bacharier, George T. O'Connor, Jessica Lasky-Su, Scott T. Weiss, Augusto A. Litonjua
Summary: Low gestational 25(OH)D level and childhood asthma are important risk factors for decreased lung function in early childhood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Letter
Allergy
Anna Clara Rabha, Fatima Rodrigues Fernandes, Dirceu Sole, Leonard Benjamin Bacharier, Gustavo Falbo Wandalsen
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The article summarizes key recommendations from GINA 2021 and the recent changes, highlighting the importance of not relying solely on short-acting beta(2)-agonists for asthma treatment and provides targeted treatment suggestions based on severity and age.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Allergy
Bradley E. Chipps, Kevin R. Murphy, Robert A. Wise, William A. McCann, David A. Beuther, Joan Reibman, Maureen George, Ileen Gilbert, James M. Eudicone, Hitesh N. Gandhi, Gale Harding, Melissa Ross, Robert S. Zeiger
Summary: The study aimed to evaluate the construct validity of the Asthma Impairment and Risk Questionnaire (AIRQ). The results showed that the AIRQ classified asthma control similarly to the Asthma Control Test (ACT) and exacerbation validation standard, and exhibited construct validity with a 3-month recall period for exacerbation-based risk questions. Worsening AIRQ control levels were associated with higher proportions of exacerbations and greater asthma morbidity according to patient global self-assessments.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Editorial Material
Allergy
Leonard B. Bacharier
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Respiratory System
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an evidence-based strategy for asthma management and prevention, emphasizing the importance of regular personalized assessment, treatment of modifiable risk factors, self-management education, and appropriate medication adjustment for optimizing asthma outcomes.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Respiratory System
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The GINA Strategy Report provides clinicians with an evidence-based strategy for asthma management and prevention, with specific recommendations and treatment options for different age groups and severity levels. Regular personalized assessment, treatment of modifiable risk factors, and appropriate medication adjustment and review remain essential for optimizing asthma outcomes.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Allergy
Kathleen Lee-Sarwar, Sandra Dedrick, Babak Momeni, Rachel S. Kelly, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Nancy Laranjo, Diane R. Gold, Jessica Lasky-Su, Augusto A. Litonjua, Yang-Yu Liu, Scott T. Weiss
Summary: This study analyzed the relationship between gut microbiome and metabolome and wheeze frequency in children with asthma. The results showed that specific microbial taxa and metabolites were associated with high wheeze proportion in children. This finding suggests the impact of the gut microbiome on asthma morbidity in children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Robert S. Zeiger, Michael Schatz, Yichen Zhou, Fagen Xie, Vishal Bali, Jonathan Schelfhout, Amar Das, Julie A. Stern, Wansu Chen
Summary: This retrospective study analyzed the risk factors of persistent chronic cough (PCC) in patients diagnosed with chronic cough by specialists. The results showed that factors such as old age, female gender, low education level, comorbidities, specific medication use, and specialist care, particularly with pulmonologists, were associated with PCC.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Kathleen A. Lee-Sarwar, Yih-Chieh Chen, Yuan Yao Chen, Anita L. Kozyrskyj, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Hans Bisgaard, Jakob Stokholm, Bo Chawes, Soren J. Sorensen, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Vincent J. Carey, Benjamin J. Harshfield, Nancy Laranjo, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua
Summary: This study found associations between prenatal and early-life fecal microbiomes and childhood asthma phenotypes. Cesarean section was found to increase the risk of early asthma.
Article
Pharmacology & Pharmacy
Greg E. Davis, Robert S. Zeiger, Benjamin Emmanuel, Yen Chung, Trung N. Tran, Kristin A. Evans, Stephanie Chen, Rohit Katial, James L. Kreindler, Joseph Tkacz
Summary: In patients with chronic rhinosinusitis with nasal polyposis (CRSwNP), the use of systemic corticosteroids (SCS) is associated with a higher risk of adverse outcomes and increased healthcare costs compared to controls without SCS exposure. Alternative treatment strategies that avoid or reduce SCS use may decrease healthcare costs.
CLINICAL THERAPEUTICS
(2022)
Article
Allergy
Yih-Chieh S. Chen, Kathleen A. Lee-Sarwar, Hooman Mirzakhani, George T. O'Connor, Leonard B. Bacharier, Robert S. Zeiger, Hanna M. Knihtila, Anjali Jha, Rachel S. Kelly, Nancy Laranjo, Raina N. Fichorova, Ngan Luu, Scott T. Weiss, Augusto A. Litonjua
Summary: Prenatal systemic inflammation, as measured by plasma CRP, is associated with childhood asthma, eczema, and allergic rhinitis. Elevated early and late prenatal CRP and an increase in CRP from early to late pregnancy are linked to the development of childhood asthma. This association is particularly strong for children with atopic asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
David A. Beuther, Kevin R. Murphy, Robert S. Zeiger, Robert A. Wise, William McCann, Joan Reibman, Maureen George, Ileen Gilbert, James M. Eudicone, Hitesh N. Gandhi, Melissa Ross, Karin S. Coyne, Bradley Chipps
Summary: The study evaluated the ability of the Asthma Impairment and Risk Questionnaire (AIRQ) to predict exacerbations reported by patients over a 12-month period. The results demonstrated that the control level assessed by AIRQ can predict exacerbation risk and the probability of time to first exacerbation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)